Navigation Links
New Queen's University research sheds light on gene destruction linked to aggressive prostate cancer
Date:1/26/2012

Researchers at Queen's University in Kingston, Canada have identified a possible cause for the loss of a tumour suppressor gene (known as PTEN) that can lead to the development of more aggressive forms of prostate cancer.

"This discovery gives us a greater understanding of how aggressive prostate cancer develops because we now have some insight into the mechanism by which the PTEN gene is destroyed," says Jeremy Squire, a professor in the Department of Pathology and Molecular Medicine.

PTEN is one of a small class of tumor suppressor genes that closely regulates the growth of cells. When PTEN is altered or deleted in prostate cells, they lose the ability to make a protein that controls normal growth. Cells can then grow uncontrolled and can develop into a prostate cancer.

Dr. Squire, with his postdoctoral fellow Maisa Yoshimoto, examined cancerous tissue samples and determined that the loss of the PTEN gene occurred close to a large, unstable segment of DNA. Their discovery suggests that proximity of PTEN to this region makes cancer-suppressing genes more prone to being deleted or inactivated.

Researchers discovered the gene using a novel gene-detection technology developed by Dr. Squire and his laboratory. They identified and analyzed with unprecedented accuracy the loss of critical tumour genes using a highly sensitive fluorescent labelling system. The technology significantly improves on current methods for identifying PTEN loss and has the potential to lead to better treatment of prostate cancer patients.

The Del-TECT gene-detection technology was licensed to CymoGen Dx through PARTEQ Innovations, Queen's technology transfer office last year. CymoGen DX invented the labeling system.

The researchers' findings appear in the current edition of the journal Genes, Chromosomes and Cancer.


'/>"/>

Contact: Michael Onesi
Michael.Onesi@queensu.ca
613-533-6000 x77513
Queen's University
Source:Eurekalert

Page: 1

Related medicine news :

1. New York Personal Injury Lawyers Concerned About Toyota Accident in Queens
2. ENT and Allergy Associates Welcomes Tamekia L. Wakefield, MD, Further Reinforcing its Pediatric Sinus Expertise and Capabilities in Queens
3. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
4. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
5. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
6. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
7. Smithsonian Institution, Arizona State University announce education and research partnership
8. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
9. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
10. Arizona State Universitys Decision Theater offers balance to an off-kilter world
11. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System ... procedure adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. ...
(Date:3/28/2017)... ... , ... Oily skin is a common and unwelcomed occurrence in people of all ages, genders ... offer to the discussion of dealing with excess skin oil. “Oily skin is a challenge ... that can help remove the oily shine while keeping the skin fresh and clean,” says ...
(Date:3/27/2017)... ... March 27, 2017 , ... New patients who have ... sleep apnea treatment, with or without a referral. Sleep apnea is often left untreated ... daytime sleepiness, morning headaches and chronic snoring. , Dr. Braasch seeks to raise ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... gain site attention and engagement over the household brands of Top-20 pharma by ... will discuss how partnering with the right outsourcing payments provider can provide the ...
(Date:3/27/2017)... ... 27, 2017 , ... Adding to its expanding portfolio of ... and NEJM Journal Watch, announces the release of NEJM Knowledge+ Pediatrics Board ... of pediatricians from leading medical centers. The content was then reviewed and approved ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017  iCAD (Nasdaq: ICAD), an ... and radiation therapy for the early identification and ... Detection received Premarket Approval (PMA) from the U.S. ... is a first-of-its-kind, concurrent-read computer aided detection solution ... latest innovation available on the PowerLook® Breast Health ...
(Date:3/27/2017)... 27, 2017  PhaseRx, Inc. (NASDAQ: PZRX), a ... liver diseases in children, today reported financial results ... December 31, 2016 and provided an update on ... to make progress during the fourth quarter of ... our non-human primate safety study, and with our lead ...
(Date:3/24/2017)... PUNE, India , March 24, 2017 Abdominal ... to reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% from 2016 ... revenue, and is projected to dominate the market during the study period. ... ... Logo ...
Breaking Medicine Technology: