Navigation Links
New Queen's University research sheds light on gene destruction linked to aggressive prostate cancer
Date:1/26/2012

Researchers at Queen's University in Kingston, Canada have identified a possible cause for the loss of a tumour suppressor gene (known as PTEN) that can lead to the development of more aggressive forms of prostate cancer.

"This discovery gives us a greater understanding of how aggressive prostate cancer develops because we now have some insight into the mechanism by which the PTEN gene is destroyed," says Jeremy Squire, a professor in the Department of Pathology and Molecular Medicine.

PTEN is one of a small class of tumor suppressor genes that closely regulates the growth of cells. When PTEN is altered or deleted in prostate cells, they lose the ability to make a protein that controls normal growth. Cells can then grow uncontrolled and can develop into a prostate cancer.

Dr. Squire, with his postdoctoral fellow Maisa Yoshimoto, examined cancerous tissue samples and determined that the loss of the PTEN gene occurred close to a large, unstable segment of DNA. Their discovery suggests that proximity of PTEN to this region makes cancer-suppressing genes more prone to being deleted or inactivated.

Researchers discovered the gene using a novel gene-detection technology developed by Dr. Squire and his laboratory. They identified and analyzed with unprecedented accuracy the loss of critical tumour genes using a highly sensitive fluorescent labelling system. The technology significantly improves on current methods for identifying PTEN loss and has the potential to lead to better treatment of prostate cancer patients.

The Del-TECT gene-detection technology was licensed to CymoGen Dx through PARTEQ Innovations, Queen's technology transfer office last year. CymoGen DX invented the labeling system.

The researchers' findings appear in the current edition of the journal Genes, Chromosomes and Cancer.


'/>"/>

Contact: Michael Onesi
Michael.Onesi@queensu.ca
613-533-6000 x77513
Queen's University
Source:Eurekalert

Page: 1

Related medicine news :

1. New York Personal Injury Lawyers Concerned About Toyota Accident in Queens
2. ENT and Allergy Associates Welcomes Tamekia L. Wakefield, MD, Further Reinforcing its Pediatric Sinus Expertise and Capabilities in Queens
3. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
4. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
5. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
6. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
7. Smithsonian Institution, Arizona State University announce education and research partnership
8. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
9. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
10. Arizona State Universitys Decision Theater offers balance to an off-kilter world
11. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. ... Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at an early ... medicine is about more than making diagnoses and prescribing medicine,” he states. “It is ...
(Date:12/2/2016)... , ... December 02, 2016 , ... More than half ... while 84 percent of parents report speaking with their child about sex related topics, ... transmitted diseases. , Mediaplanet is proud to announce the launch of its second edition ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical Systems, Inc. (UMS) ... first company to offer robotic imaging to veterinary medicine is sponsoring the appearance ... for the American Association of Equine Practitioners 62nd Annual Convention from December 4-6, ...
(Date:12/2/2016)... ... December 02, 2016 , ... "Pro3rd Accents Volume 2 is ... create versatile lower third titles with just a few clicks of the mouse," said ... includes 30 lower third animations. Choose from various styles with accented animations, rigid boxes, ...
(Date:12/2/2016)... ... 02, 2016 , ... Date aired: November 28, 2016 , ... The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein , Sharon Kleyne, America’s leading water ... Change and Your Health radio program syndicated on Voice of America, welcomed author ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... , Dec. 3, 2016   Pairnomix, LLC, ... Medicine Alliance (PEPMA) recognized by the White House, today announced ... approach to the identification of candidate therapies for a patient ... SCN8A gene were presented at the 70 th ... Houston, TX , December 2-6, 2016.  ...
(Date:12/2/2016)... Research and Markets has announced the addition of the ... ... R&D Drug Pipeline Database: 1-Year Subscription ... provides 24/7 online access to information about more than 21,000 project ... drug candidates in research & development. Pre-established and ...
(Date:12/2/2016)... the ECG Cables And ECG Leadwires Market owing to the ... On the other hand, the Asia-Pacific ... during the forecast period. The market players namely, ... ( Ireland ), Koninklijke Philips N.V. ( ... China ), held major share of the ECG ...
Breaking Medicine Technology: