Navigation Links
New Proteins That Help HIV Grow Identified
Date:1/10/2008

Finding could lead to treatments for when antiviral drugs fail

THURSDAY, Jan. 10 (HealthDay News) -- Harvard researchers have identified almost 300 human proteins that help HIV propagate, creating hope for new treatments to combat the virus that causes AIDS.

Using a technique called RNA interference to screen thousands of genes, the team identified 273 human proteins, according to the study published online Jan. 10 in Science Express. These proteins could provide a way to help people with HIV when the virus develops resistance to current antiviral drugs.

"Antiviral drugs are currently doing a good job of keeping people alive, but these therapeutics all suffer from the same problem, which is that you can get resistance, so we decided to take a different approach centered on the human proteins exploited by the virus. The virus would not be able to mutate to overcome drugs that interact with these proteins," senior author Stephen Elledge, a professor in Harvard Medical School's department of genetics, said in a prepared statement.

The expanded list of proteins gives future researchers "a hypothesis generation machine," he said.

"Scientists can look at the list, predict why HIV needs a particular protein, and then test their hypothesis," Elledge explained.

He noted that immune cells -- which are targeted by HIV -- contain high concentrations of many of the 273 proteins.

"We're closing in on a systems level understanding of HIV, which opens new therapeutic avenues. We might be able to tweak various parts of the system to disrupt (HIV) propagation without making our own cells sick," Elledge said.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Harvard Medical School, news release, Jan. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists get first look at how water lubricates proteins
2. 2 proteins may be survival markers in some breast cancers
3. Immune Proteins Warn of Early Lung Cancer
4. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
5. Heat shock proteins are co-opted for cancer
6. Penn study finds pro-death proteins required to regulate healthy immune function
7. Smallpox vaccine alternative identified
8. Domestic violence identified as stressor associated with smoking
9. Stem Cell Institute Correct in Rejecting Applications Over Conflicts of Interest; Institutions, Board Members Involved Must Be Identified, Consumer Advocates Say
10. Pheromones identified that trigger aggression between male mice
11. Genes identified that protect against heart damage from chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Proteins That Help HIV Grow Identified
(Date:5/31/2016)... PA (PRWEB) , ... May 31, 2016 , ... More ... Philadelphia, Hep B United Philadelphia, and the Prevent Cancer Foundation held an event on ... silent epidemic in the city of viral hepatitis, the leading cause of liver cancer. ...
(Date:5/31/2016)... ... May 31, 2016 , ... Splashtop Inc., the worldwide leader in ... Networks Co., the leading provider of secure mobile remote access solution for Japan ... leading CACHATTO remote access solution. Splashtop for CACHATTO will be available as ...
(Date:5/31/2016)... ... ... Twenty years ago it was revolutionary: enabling the people who hear distressing voices ... But this approach has proven transformative, both for people who hear voices and for ... is used around the world, but it still lags in the United States. , ...
(Date:5/31/2016)... ... May 31, 2016 , ... When ... he knew it was something that contractors should have at their disposal on ... gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a result, ...
(Date:5/31/2016)... ... May 31, 2016 , ... CallTrackingMetrics's software ... campaigns, to monitor the performance of sales and support staff, and to efficiently ... The software allows customers to record, transcribe, route, document, and report on everything ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016 According to a new ... Market - U.S. Industry Analysis, Size, Share, Growth, Trends, and ... the U.S. was valued at US$ 5.89 Bn in 2014 ... from 2015 to 2023 to reach US$ 7.99 Bn in ... and emerging needle free drug delivery devices and the market ...
(Date:5/26/2016)... 26, 2016 TARE (Transarterial ... Cost Savings and Overall Decreased Use of ... an international specialist healthcare company, has today announced ... Annual Meeting of ISPOR (International Society for Pharmacoeconomics ... carcinoma (HCC) using yttrium-90 glass microspheres is associated ...
(Date:5/26/2016)... , May 26, 2016 ... has matured into an essential life science tool for ... development applications. BCC Research reveals in its new report ... second growth phase, one powered by a range of ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
Breaking Medicine Technology: