Navigation Links
New Proteins That Help HIV Grow Identified
Date:1/10/2008

Finding could lead to treatments for when antiviral drugs fail

THURSDAY, Jan. 10 (HealthDay News) -- Harvard researchers have identified almost 300 human proteins that help HIV propagate, creating hope for new treatments to combat the virus that causes AIDS.

Using a technique called RNA interference to screen thousands of genes, the team identified 273 human proteins, according to the study published online Jan. 10 in Science Express. These proteins could provide a way to help people with HIV when the virus develops resistance to current antiviral drugs.

"Antiviral drugs are currently doing a good job of keeping people alive, but these therapeutics all suffer from the same problem, which is that you can get resistance, so we decided to take a different approach centered on the human proteins exploited by the virus. The virus would not be able to mutate to overcome drugs that interact with these proteins," senior author Stephen Elledge, a professor in Harvard Medical School's department of genetics, said in a prepared statement.

The expanded list of proteins gives future researchers "a hypothesis generation machine," he said.

"Scientists can look at the list, predict why HIV needs a particular protein, and then test their hypothesis," Elledge explained.

He noted that immune cells -- which are targeted by HIV -- contain high concentrations of many of the 273 proteins.

"We're closing in on a systems level understanding of HIV, which opens new therapeutic avenues. We might be able to tweak various parts of the system to disrupt (HIV) propagation without making our own cells sick," Elledge said.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Harvard Medical School, news release, Jan. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists get first look at how water lubricates proteins
2. 2 proteins may be survival markers in some breast cancers
3. Immune Proteins Warn of Early Lung Cancer
4. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
5. Heat shock proteins are co-opted for cancer
6. Penn study finds pro-death proteins required to regulate healthy immune function
7. Smallpox vaccine alternative identified
8. Domestic violence identified as stressor associated with smoking
9. Stem Cell Institute Correct in Rejecting Applications Over Conflicts of Interest; Institutions, Board Members Involved Must Be Identified, Consumer Advocates Say
10. Pheromones identified that trigger aggression between male mice
11. Genes identified that protect against heart damage from chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Proteins That Help HIV Grow Identified
(Date:2/26/2017)... ... February 26, 2017 , ... LatitudeC Baby ... America, today announced it would be offering some it’s exclusive product line to ... crafting quality and unique baby clothing/feeding products, will team up with AMAZON to ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... in persons with a specific LRRK2 mutation, according to a study released today ... have provided evidence of a link between pesticides and incidence of sporadic PD ...
(Date:2/24/2017)... ... February 24, 2017 , ... WHAT: , ... and recognition opportunities as well as advocacy for the state and region‘s technology ... February 23. The Council's Innovation Forecast event highlights innovation throughout the region ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... it is so critically important that we all are aware of our options ... Mediaplanet is proud to announce the launch of its newest edition of "Vision ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... Yisrayl Hawkins, ... focuses on Bible Prophecy concerning this present generation. Yisrayl makes an astounding statement ... current generation. He explains that the Bible details the current times so plainly ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Medical information groups within ... their self-service capabilities to manage inquiries from external ... New research from consulting leader Best Practices, ... self-service website portals where HCPs can sign on ... of many findings to emerge from the new ...
(Date:2/24/2017)... 24. Februar 2017 ITL Limited, ( ... Gesundheitsbereiches, ist erfreut, für das zum 31. Dezember ... Vorjahreszeitraum exzellente Ergebnisse vorlegen zu können. Eine vollständige ... Wachstum" finden Sie hier . ... Steuern 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
(Date:2/24/2017)... Feb. 23, 2017 Non-alcoholic steatohepataitis ... the various drugs being developed for the ... the drugs that are in various phases ... pipeline focuses on novel pharmacologic drugs & ... cell therapies, recombinant proteins and RNA-based therapeutics, ...
Breaking Medicine Technology: