Navigation Links
New Prostrates Grown From Single Stem Cell
Date:10/22/2008

Researchers think feat could shed light on how cancer develops

WEDNESDAY, Oct. 22 (HealthDay News) -- Using just a single adult stem cell, scientists say they have grown entire prostates in mice.

This feat was made possible by the identification of a genetic signature distinguishing stem cells from other types of cells, according to a report in the Oct. 23 issue of Nature.

This information still has to be confirmed in humans, but understanding normal cells should eventually lead to an understanding of how prostate cancer develops.

"It's another step showing that stem cells can be a root case of a cancer . . . so it gives targets for treatment," said Dr. Darwin Prockop, the Stearman Chair in Genomic Medicine, a professor of molecular and cellular medicine at Texas A&M Health Science Center College of Medicine, and director of the Institute for Regenerative Medicine at Scott & White in Temple, Texas.

"This provides ways to understand prostate cancer that might be related to stem cells," added Paul Sanberg, distinguished professor of neurosurgery and director of the University of South Florida Center of Excellence for Aging and Brain Repair in Tampa.

Stem cells have the ability to differentiate into many types of cells in the body. As such, they hold the promise of leading to treatments, and possibly, one day, even cures for neurological and many other diseases.

Many scientists believe stem cells in normal tissue are the same cells that give rise to cancer. But study co-author Leisa Johnson, a senior scientist with Genentech in San Francisco, said that point has not yet been proven.

In rodents, the normal prostate undergoes up-and-down cycles of androgen (a male hormone), indicating to researchers the presence of prostate stem cells. But how to identify them?

Several markers have been reported on the surface of these stem cells, but they also are present in other cells, making differentiation difficult.

The authors of this paper found a new marker, CD117, which, when combined with previously known prostate stem cell cancer markers, could identify a single, normal prostate stem cell.

That single stem cell was able to generate functional prostates and was also capable of renewing itself.

"We are trying to first define what is the normal cell compartment that can generate a tissue," Johnson explained. "Once we have that knowledge, is it that compartment that goes awry when cancer initiates? What is the resistant population, and what is regenerating a tumor? Is it the same cell responsible for generating normal tissue?" she said.

More information

The U.S. National Institutes of Health has more on stem cells.



SOURCES: Paul Sanberg, Ph.D., D.Sc., distinguished professor of neurosurgery and director, University of South Florida Center of Excellence for Aging and Brain Repair, Tampa, Fla.; Darwin Prockop, M.D., Ph.D., Stearman Chair in Genomic Medicine and professor, molecular and cellular medicine, Texas A&M Health Science Center College of Medicine and director, Institute for Regenerative Medicine, Scott & White, Temple, Texas; Leisa Johnson, Ph.D., senior scientist, Genentech, San Francisco, Oct. 23, 2008, Nature


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. GERD Not Limited to Grownups
2. U.S. Food Safety: Home-Grown Problems Abound
3. Kids Growing Up on Grown Up Drugs: New Research Shows Treatments for Adult Ailments Rapidly Rising in Children
4. Replacement Bladder Grown From Bodys Own Cells
5. Heart Blood Vessels Grown in the Lab
6. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
7. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
8. Milestone Scientific Commences Declaratory Judgment Action With Respect to Its Single Tooth Anesthesia (STA(TM)) System and Compudent(TM) System
9. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
10. International Watchdog Group Singles Out Resurrection for Anti-Union Violations
11. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Prostrates Grown From Single Stem Cell 
(Date:2/8/2016)... , ... February 08, 2016 , ... ... with BASF Human Nutrition into the Food & Beverage and ... been BASF’s channel partner throughout Canada and USA geographies east of the Rocky ...
(Date:2/8/2016)... ... February 08, 2016 , ... A man who has struggled to quit smoking, a man ... , was determined to find solutions to his problems – and he did. Now Nabat, ... is ready to introduce his breakthrough inventions to the world and better people's lives. His ...
(Date:2/8/2016)... Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... and surrounding areas with a vital new community enrichment program, has teamed up with ... local women and children suffering from intimate abuse. To support all those victimized by ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... today that nominations will be accepted February 8, 2016 through May 8, ... Awards include the Information Security Executive® of the Year, which recognizes executives ...
(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain region’s longest ... and 700 companies. Attendees also get to see the most incredible gardens and ... Home Show , at the Colorado Convention Center - 700 14th St. Denver CO, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- The leader in accelerated orthodontics, OrthoAccel ® ... recipient of the 2015 Townie Choice Award in the ... device that speeds up orthodontic tooth movement by as ... with treatment, AcceleDent was selected by orthodontists from across ... survey of the most reliable and reputable products ...
(Date:2/9/2016)... 9, 2016  Increasingly, health care professionals are enhancing ... with wireless technology. With the Vios Monitoring System from ... and remotely detect problems before they become serious by ... environments. the United States . ... . --> The Vios Monitoring System ...
(Date:2/9/2016)... 9, 2016 The new report " Global Fetal and ... Acuity Business Research & Consulting group reveals that North ... with a share of 36.4% in 2014 that translated into revenues ... the report also covers market analysis for Fetal and Neonatal care ... Asia-Pacific , Latin America , ...
Breaking Medicine Technology: