Navigation Links
New Prostrates Grown From Single Stem Cell
Date:10/22/2008

Researchers think feat could shed light on how cancer develops

WEDNESDAY, Oct. 22 (HealthDay News) -- Using just a single adult stem cell, scientists say they have grown entire prostates in mice.

This feat was made possible by the identification of a genetic signature distinguishing stem cells from other types of cells, according to a report in the Oct. 23 issue of Nature.

This information still has to be confirmed in humans, but understanding normal cells should eventually lead to an understanding of how prostate cancer develops.

"It's another step showing that stem cells can be a root case of a cancer . . . so it gives targets for treatment," said Dr. Darwin Prockop, the Stearman Chair in Genomic Medicine, a professor of molecular and cellular medicine at Texas A&M Health Science Center College of Medicine, and director of the Institute for Regenerative Medicine at Scott & White in Temple, Texas.

"This provides ways to understand prostate cancer that might be related to stem cells," added Paul Sanberg, distinguished professor of neurosurgery and director of the University of South Florida Center of Excellence for Aging and Brain Repair in Tampa.

Stem cells have the ability to differentiate into many types of cells in the body. As such, they hold the promise of leading to treatments, and possibly, one day, even cures for neurological and many other diseases.

Many scientists believe stem cells in normal tissue are the same cells that give rise to cancer. But study co-author Leisa Johnson, a senior scientist with Genentech in San Francisco, said that point has not yet been proven.

In rodents, the normal prostate undergoes up-and-down cycles of androgen (a male hormone), indicating to researchers the presence of prostate stem cells. But how to identify them?

Several markers have been reported on the surface of these stem cells, but they also are present in other cells, making differentiation difficult.

The authors of this paper found a new marker, CD117, which, when combined with previously known prostate stem cell cancer markers, could identify a single, normal prostate stem cell.

That single stem cell was able to generate functional prostates and was also capable of renewing itself.

"We are trying to first define what is the normal cell compartment that can generate a tissue," Johnson explained. "Once we have that knowledge, is it that compartment that goes awry when cancer initiates? What is the resistant population, and what is regenerating a tumor? Is it the same cell responsible for generating normal tissue?" she said.

More information

The U.S. National Institutes of Health has more on stem cells.



SOURCES: Paul Sanberg, Ph.D., D.Sc., distinguished professor of neurosurgery and director, University of South Florida Center of Excellence for Aging and Brain Repair, Tampa, Fla.; Darwin Prockop, M.D., Ph.D., Stearman Chair in Genomic Medicine and professor, molecular and cellular medicine, Texas A&M Health Science Center College of Medicine and director, Institute for Regenerative Medicine, Scott & White, Temple, Texas; Leisa Johnson, Ph.D., senior scientist, Genentech, San Francisco, Oct. 23, 2008, Nature


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. GERD Not Limited to Grownups
2. U.S. Food Safety: Home-Grown Problems Abound
3. Kids Growing Up on Grown Up Drugs: New Research Shows Treatments for Adult Ailments Rapidly Rising in Children
4. Replacement Bladder Grown From Bodys Own Cells
5. Heart Blood Vessels Grown in the Lab
6. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
7. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
8. Milestone Scientific Commences Declaratory Judgment Action With Respect to Its Single Tooth Anesthesia (STA(TM)) System and Compudent(TM) System
9. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
10. International Watchdog Group Singles Out Resurrection for Anti-Union Violations
11. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Prostrates Grown From Single Stem Cell 
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
(Date:9/12/2017)... reviews on the independent review site Consumer Affairs have ... hearing aids, ranking it higher than Miracle Ear ™, Beltone™, ... ... Aids ... that provides high performance, state-of-the-art, German-engineered hearing aids directly to consumers ...
Breaking Medicine Technology: