Navigation Links
New Phase II study shows first-line promise of lung cancer drug PF-299
Date:10/12/2010

A new-generation lung cancer drug has shown an impressive ability to prevent disease progression when administered as a first-line treatment in patients with advanced disease, investigators reported at the 35th Congress of the European Society for Medical Oncology (ESMO).

Preliminary results from an ongoing Phase-II trial of the drug PF299804 (PF-299) showed that close to 85% of patients whose cancers harbor mutated forms of the EGFR gene have remained progression-free for at least nine months, reported Dr Tony Mok from the Chinese University of Hong Kong.

While some existing drugs reversibly inhibit the cancer-linked receptor HER-1 (also known as EGFR), PF-299 is a 'pan-HER' inhibitor, which irreversibly inhibits several members of the HER family, including EGFR, HER-2 and HER-4.

"We know that PF-299 is a different compound than drugs such as erlotinib and gefitinib, targeting multiple receptors on the HER pathway," Dr Mok said. "We also know from preclinical work that PF-299 inhibits signaling in both wild-type and mutant EGFR, including forms of NSCLC that are resistant to EGFR inhibitors such as erlotinib and gefitinib."

The current trial includes patients with advanced non-small cell lung cancer and no prior systemic treatment for their disease. All were either non-smokers or light smokers, or were known to have EGFR mutations.

So far, 74 of 80 planned patients have enrolled. Of the 41 with known EGFR status, 27 had activating mutations.

Each patient was administered either 30mg or 45mg of PF-299 once daily, and were assessed every 28 days. After 9 months of treatment, 57.1% of patients overall, and 84.7% of those patients with EGFR mutations, remained progression-free, Dr Mok reported. The expected median progression-free survival with standard-of-care chemotherapy in this patient population is approximately six months.

"Even though these data are preliminary and patients are still being f
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements
2. New High Purity Immunoglobulin Enters Phase III in Europe and the US
3. Poniard Pharmaceuticals Presents Positive Survival Data from a Phase 2 Clinical Study of Picoplatin in Metastatic Prostate Cancer at the 2010 American Society of Clinical Oncology Genitourinary Cancers Symposium
4. Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial
5. Askthedoctor.com Makes Medical Information More Accessible to the Public by Completing Phase 1 of US Expansion
6. Intellicate Announces New “Phased Return to Work” (PRtW) Service
7. Southampton scientists begin Phase II patient trial for new asthma treatment
8. Pilot Testing Phase Ends; Expansion Of Sales Force Begins
9. New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
10. Phase II study of an oral therapy for Gaucher disease yields positive results
11. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 2015 NOVAtime Technology, Inc. ( ... solutions for enterprise organizations, announced today that SanMar ... automate its time, attendance and point tracking processes ... the United States. , Family-owned since 1971, ... 21 retail, private label, and mill brands. SanMar ...
(Date:5/27/2015)... The MedSpa at Hendrick is excited ... treatments in Abilene, Texas: Xeomin®, Belotero Balance® and Radiesse®. ... glabellar lines, better known as the lines between the ... to treat smoker’s lines around the mouth and marionette ... improves the appearance of smile lines or lines around ...
(Date:5/27/2015)... Chicago, IL (PRWEB) May 27, 2015 ... River North-based advertising agency, will partner with LifeSource to ... community-focused event will take place in a LifeSource donor ... 9:00 a.m. to 4:00 p.m. , Demand for whole ... center in Illinois, during the summer months. LifeSource requires ...
(Date:5/27/2015)... 2015 With InnerVoice Communication App ... the message is not only heard but seen -- by ... any motivating image. This award-winning and affordable app takes full ... Now, using InnerVoice Sender app in conjunction with ... a learner remotely for no additional cost. , InnerVoice ...
(Date:5/27/2015)... A television program using health care ... Roswell Park Cancer Institute winning a prestigious ... Cancer Can’t Win , highlights the amazing patients ... The production team followed five people who were battling ... received treatment from doctors and medical experts at Roswell. ...
Breaking Medicine News(10 mins):Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 2Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 3Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 3Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 4Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 2Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 3
... Haikerwal, today welcomed the Government’s decision to officially recognise ... training program for rural GPs. ,“Rural GPs ... Haikerwal said. ,“Formal recognition for rural GPs ... Australia’s medical workforce in rural and regional areas.” ...
... for Disease Control and Prevention say there has been a sudden ... mass index of 40 or more. ,Accordingly, not only ... from 2000 to 2005(twice as fast as the increase in moderate ... percent of overweight people (BMI of 30 or more), and ...
... role Down Under. Australian experts dabbling in this ancient ... ,A not-for-profit organisation Yoga in the Community (YITC) ... "aims to support the mental, physical and emotional well-being ... a journal published by the University of Technology, Sydney. ...
... number of organ donors, Ontario’s health ministry is considering// the ... to living donors. The health minister has promised to ... ,British Columbia coughs up nearly $5,500 as expense for people ... this scheme, nearly 43 living donors have been reimbursed their ...
... one-fourth of all stays in U.S. community hospitals for ... and other mental health disorders or substance use related ... ,This study presents the first documentation ... abuse disorders on U.S. community hospitals. According to the ...
... The Punjab government and its pharmacy council will frame ... medicines, especially among the youth. ,Medical ... Wednesday that the department and the pharmacy council would ... employed qualified pharmacists to dispense medicines to consumers. ...
Cached Medicine News:Health News:Yoga Helping Fight Autism Down Under 2Health News:One Fourth of Hospital Patients Admitted for Mental Health or Drug Abuse Disorder 2
(Date:5/27/2015)... 2015  With Freudenberg Xpress, Freudenberg-NOK Sealing ... machined seals from the original materials used ... have the same material characteristics and life ... products, can be made-to-order individual parts intended ... runs. The agenda is always: ordered, machined ...
(Date:5/27/2015)... N.J. , May 27, 2015  The ... LLC, utilizes a Motion Systems Corporation ball drive ... freedom. Motion Systems manufactures the industry,s largest selection ... to a wide array of industries, including medical ... help people who are wheelchair-bound as well as ...
(Date:5/27/2015)... SAN JOSE, Calif. , May ... Inc. (NASDAQ: MXIM ) makes ... medical sensor and to monitor or ... with the DS28E80 gamma-radiation-resistant, nonvolatile (NV) ... Details for DS28E80: http://www.maximintegrated.com/en/products/digital/memory-products/DS28E80.html ...
Breaking Medicine Technology:Xpress Service from Freudenberg-NOK Quickly Delivers Made-to-Order Sealing Solutions to Customers 2Innovative Technology Liberates the Wheelchair-Bound 2Gamma-Radiation-Resistant Memory Provides Calibration and Protects from Unsanitary Reuse in Medical Disposables 2Gamma-Radiation-Resistant Memory Provides Calibration and Protects from Unsanitary Reuse in Medical Disposables 3
... CareFusion Corporation (NYSE: CFN ) today announced plans to release third ... close of trading on the New York Stock Exchange. , ... The company will host a webcast and conference call on May 6 ... to discuss the results for its third quarter, ended on March 31, 2010 ...
... April 27 Kincannon & Reed Global Executive Search, a growing ... to the newly created position of Managing Director, Biopharmaceutical Life Sciences, effective ... , , ... this important new position. We recognize how important it is for our ...
Cached Medicine Technology:CareFusion Will Host an Earnings Conference Call on May 6 to Discuss the Results for the Third Quarter of Fiscal 2010 2Kincannon & Reed Names David G. Jensen as Managing Director, Biopharma Life Sciences 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: