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New Once-Daily RYZOLT(TM) (tramadol HCl extended-release tablets) Now Available in the U.S.
Date:5/7/2009

STAMFORD, Conn., May 7 /PRNewswire/ -- RYZOLT(TM) (tramadol HCl extended-release tablets) is now available from Purdue Pharma L.P. for the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time.

(Photo: http://www.newscom.com/cgi-bin/prnh/20090507/NY13103)

RYZOLT's active ingredient, tramadol, is a centrally-acting synthetic opioid analgesic that binds to the mu -opioid receptor and also inhibits the reuptake of both serotonin and norepinephrine. Taken once every 24 hours, RYZOLT offers convenient dosing in 100 mg (NDC 59011-334-30), 200 mg (NDC 59011-335-30), and 300 mg (NDC 59011-336-30) tablet strengths. Eligible patients prescribed RYZOLT may receive a special RYZOLT Patient Value Card from their physician that can be applied at the pharmacy for immediate value of up to 14 days of RYZOLT, and extended value of up to $35 dollars off their out-of-pocket costs for each prescription filled (after paying the first $10), until December 31, 2010(1).

RYZOLT was developed by Labopharm Inc. (Nasdaq: DDSS; TSX: DDS) of Canada and approved by the U.S. Food and Drug Administration (FDA) in December 2008. The product is based on Labopharm's proprietary Contramid(R) controlled-release technology, featuring a dual-matrix delivery system with both immediate-release and extended-release characteristics.

"RYZOLT expands our commitment to provide a range of pain management treatments for healthcare professionals to consider when they diagnose and treat the many painful conditions that affect millions of Americans," said John H. Stewart, Pr
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SOURCE Purdue Pharma L.P.
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