Navigation Links
New Notre Dame paper offers insights into how cancer cells avoid cell death
Date:6/21/2013

A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may suggest a chemotherapeutic approach to prevent the spread of cancers.

Metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells ability to evade a cell death process called anoikis, according to Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame. Metalizing cancer cells are able to survive anoikis, which normally results from detachment from the extracellular matrix. However, Schafer notes that the molecular mechanisms cancer cells detached from the extracellular matrix use to survive has not been well understood.

"This paper reveals that cancer cells that are detached from their normal environment, as they would be during metastasis, relay on the activity of antioxidant enzymes to facilitate their survival," Schafer said. "This class of enzymes is critical for neutralizing oxidative stress and function much like the compounds that are present in a variety of foods."

The paper describes a prominent role for antioxidant enzymes in facilitating the survival of breast cancer cells after detachment from the extracellular matrix. Conversely, the researchers report, silencing antioxidant enzyme expression reduced tumor formation.

"The results in this paper suggest that targeting antioxidant enzymes with novel therapeutics may selectively kill off metastasizing cancer cells," Schafer said.

The paper appears in the journal Cancer Research, which is the most frequently cited cancer journal in the world.

The researchers collaborated with Matthew Leevy in Notre Dame's in vivo imaging facility.

Other authors of the paper include doctoral student Calli Davison, rising junior Sienna Durbin, 2011 alum Matthew Thau, graduate student Victoria Zellmer, and Sarah Chapman, Justin Diner and Connor Wathen from the Notre Dame Integrated Imaging Facility.


'/>"/>

Contact: Zachary T. Schafer
zschafe1@nd.edu
574-631-0875
University of Notre Dame
Source:Eurekalert

Related medicine news :

1. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
2. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
3. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
4. Internal medicine physician specialists release policy paper on reforming Medicaid
5. Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC
6. New iTeen365 White Paper Identifies Dangerous Driving Distractions – Offers Solutions for Parents of Teen Drivers
7. Book Banning: The Illinois Department of Corrections Bans The Cannabis Papers by “Publius”
8. Widespread exposure to BPA substitute is occurring from cash register receipts, other paper
9. BPA Substitute Lurks in Paper Money, Receipts
10. Minneapolis Heart Institute Foundation welcomes Europace publication of Optim™ lead insulation paper
11. Minneapolis Heart Institute Foundation welcomes Europace publication of Optim lead insulation paper
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia Medical ... 2017. The name change aligns the entire company with its existing Quality ... quality. , “We are very proud of the achievements associated with the West ...
(Date:12/8/2016)... ... December 08, 2016 , ... After enjoying ... opened registration today for its 33rd Annual Issues & Research Conference, March ... The theme of the conference is “Persistent Challenges and New Opportunities: Using Research ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... pleased to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate ...
(Date:12/8/2016)... ... December 08, 2016 , ... Mirixa Corporation ... adherence, and other pharmacist-delivered patient care services, has announced the promotions of Karen ... to vice president of sales. , Litsinger joined Mirixa in 2008 after ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental ... dentists and patients about the safety issues related to dental restorations. According to the ... is projected to reach $6.4 billion in 2018 with more than 30 million Americans ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Eli Lilly and Company ... of its phase 3 EXPEDITION3 trial at the 9 ... As previously disclosed, solanezumab did not meet the primary ... solanezumab initiated in people with mild dementia due to ... submissions for solanezumab for the treatment of mild dementia ...
(Date:12/8/2016)...   TriNetX , the health research network, ... signed a membership agreement to join the network ... cures. The TriNetX network is comprised ... globally, biopharmaceutical companies and contract research organizations (CROs) ... site selection, patient recruitment, and collaborative research across ...
(Date:12/8/2016)...  A new study by a pair of Geisinger ... therapy to treat chronic pain is not only ineffective, ... consequences, including death. Palliative care physicians ... , M.D., authored the study which provides a review ... study was published in the December 2016 edition of ...
Breaking Medicine Technology: