Navigation Links
New Notre Dame paper offers insights into how cancer cells avoid cell death
Date:6/21/2013

A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may suggest a chemotherapeutic approach to prevent the spread of cancers.

Metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells ability to evade a cell death process called anoikis, according to Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame. Metalizing cancer cells are able to survive anoikis, which normally results from detachment from the extracellular matrix. However, Schafer notes that the molecular mechanisms cancer cells detached from the extracellular matrix use to survive has not been well understood.

"This paper reveals that cancer cells that are detached from their normal environment, as they would be during metastasis, relay on the activity of antioxidant enzymes to facilitate their survival," Schafer said. "This class of enzymes is critical for neutralizing oxidative stress and function much like the compounds that are present in a variety of foods."

The paper describes a prominent role for antioxidant enzymes in facilitating the survival of breast cancer cells after detachment from the extracellular matrix. Conversely, the researchers report, silencing antioxidant enzyme expression reduced tumor formation.

"The results in this paper suggest that targeting antioxidant enzymes with novel therapeutics may selectively kill off metastasizing cancer cells," Schafer said.

The paper appears in the journal Cancer Research, which is the most frequently cited cancer journal in the world.

The researchers collaborated with Matthew Leevy in Notre Dame's in vivo imaging facility.

Other authors of the paper include doctoral student Calli Davison, rising junior Sienna Durbin, 2011 alum Matthew Thau, graduate student Victoria Zellmer, and Sarah Chapman, Justin Diner and Connor Wathen from the Notre Dame Integrated Imaging Facility.


'/>"/>

Contact: Zachary T. Schafer
zschafe1@nd.edu
574-631-0875
University of Notre Dame
Source:Eurekalert

Related medicine news :

1. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
2. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
3. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
4. Internal medicine physician specialists release policy paper on reforming Medicaid
5. Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC
6. New iTeen365 White Paper Identifies Dangerous Driving Distractions – Offers Solutions for Parents of Teen Drivers
7. Book Banning: The Illinois Department of Corrections Bans The Cannabis Papers by “Publius”
8. Widespread exposure to BPA substitute is occurring from cash register receipts, other paper
9. BPA Substitute Lurks in Paper Money, Receipts
10. Minneapolis Heart Institute Foundation welcomes Europace publication of Optim™ lead insulation paper
11. Minneapolis Heart Institute Foundation welcomes Europace publication of Optim lead insulation paper
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... CA (PRWEB) , ... January 21, 2017 , ... ... Director of Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for its ... for alumni, family, friends, and community. “Coming Home 2017” will be held ...
(Date:1/21/2017)... ... 2017 , ... The Nobel Biocare™ dental implant company is ... its creos™ line of bone regenerative products. Specifically, the Nobel Biocare™ ... creos™ allo.gain™ bone graft for a variety of bone reconstruction procedures. In addition ...
(Date:1/20/2017)... Raton, FL (PRWEB) , ... January 20, 2017 , ... ... seaweeds, botanicals and 100 percent pure essential oils, announced the company had a successful ... SC. , The annual ECRM event gives companies that work in the nutritional, sports ...
(Date:1/20/2017)... Boca Raton, FL (PRWEB) , ... January 20, ... ... creating nutritional and wellness products to enhance people’s everyday lives, recently attended the ... major retail buyers. , ATP Science is known for its large range of ...
(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin ... alternative VW+ 002. The drinks have been produced in collaboration with Zlatan Ibrahimovic ... during your workout. , After a successful launch in Sweden last year, the ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... SAN DIEGO and PALMA, ... Laboratoris Sanifit S.L., a clinical-stage biopharmaceutical ... announced that the first patient has been enrolled ... of lead candidate, SNF472, for the treatment of ... haemodialysis (HD). Most ESRD patients, in ...
(Date:1/22/2017)... and ABU DHABI , Saudi Arabia ... from the US ... Hospital of the Future , at the World Economic ... of the future will be driven by big data and powered by artificial ... the panel of experts that discussed the ,Hospital of the Future, at the ...
(Date:1/21/2017)... 20, 2017 ARMO BioSciences, Inc., a late-stage ... the Company,s lead investigational immuno-oncology drug AM0010 (PEGylated Interleukin-10) ... American Society of Clinical Oncology (ASCO), taking place January ... "AM0010 induces the expansion of ... T cells in the blood and tumors of our ...
Breaking Medicine Technology: