Navigation Links
New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
Date:6/16/2008

>

But almost all cancers in this category eventually become resistant to tamoxifen and, in some cases, tamoxifen may even turn the tables and start acting like estrogen, thereby fueling tumor growth.

Through extensive laboratory testing, the study authors identified a group of compounds related to TPBM that interfered with estrogen's effect on breast cancer cells via a different pathway. The molecules work by affecting the way estrogen receptors interact with a woman's DNA, the researchers said.

TPBM has the advantage of being "highly specific" and therefore much less likely to have any unwanted effects on other cells. It also works against tamoxifen when tamoxifen starts fueling tumor growth, the researchers said.

"As we look forward with all of our research and our capabilities, we'll hopefully continue to discover new ways to exploit hormone sensitivity," Lichtenfeld said. "This may be the next pathway, although we can't say that for sure... Hormonal approaches to breast cancer continue to add, literally, years to lives."

More information

For more on treating breast cancer, visit the National Cancer Institute.



SOURCES: Jay Brooks, M.D., chairman of hematology/oncology, Ochsner Health Service, Baton Rouge, La.; Len Lichtenfeld, M.D., deputy chief medical officer, American Cancer Society, Atlanta; June 16, 2008, presentation, The Endrocine Society annual meeting, San Francisco


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... Freeport, ME (PRWEB) , ... September 01, 2015 , ... ... a large, new study that followed men and women for 19 years and found ... those who did not take multivitamins. , The report is part of the September ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, ... has joined its medical management team as an Associate Medical Director. , ... and types in the U.S. and abroad. , Dr. Nelson has a ...
(Date:9/1/2015)... D.C. (PRWEB) , ... September 01, 2015 , ... Two ... better cross cultural relations through food and dining. , Recently named “the next ... and Luigi Diotaiuti are known for telling the whole story behind food and reclaiming ...
(Date:9/1/2015)... MD (PRWEB) , ... September 01, 2015 , ... SC&H ... Accounting (IPA), which includes being named a “Best of the Best” firm in the ... IPA has named the “Best of the Best” in the U.S., selected exclusively on ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... Connectivity Kit is now available. With the Connectivity Kit, EasySampler data ... automated jacketed lab reactor control experiment, on a touchscreen platform. , EasySampler fully ...
Breaking Medicine News(10 mins):Health News:New Study Finds Multivitamins Extend Life After Stroke, Retailer Reports 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 3
... 26 Three years ago, Leverage,Life began offering an ... Hotline program has proven to be a much-needed,benefit for ... that by 2012 the growth of the,workforce will be ... decline by nearly,three million, or 6.8%, and workers over ...
... Their Children Help Care for Loved Ones With ... ... third annual,Alzheimer,s Foundation of America (AFA) ICAN: Investigating Caregivers,Attitudes and Needs ... caregivers" -- the parents or guardians of,children under 21 who also ...
... EVANSTON, Ill., March 26 Mentice, Inc. (a ... leading supplier of,virtual reality based training applications within ... as Vice-President of Sales and,Marketing, Americas., Mr. ... sales, sales management,and marketing experience within the areas ...
... March 26 Lifeway Foods,Inc. (Nasdaq: LWAY ) announces the following Webcast:, ... When: March 31, 2008 @ 4:00 pm Central, ... Live over the Internet -- Simply log on to ... address above., Contact: Edward Smolyansky of Lifeway ...
... Calif., March 26 Murad, where skincare,meets healthcare(R), ... demand for its products continues to increase Internationally.,The ... of,International Sales, Jean Runel, will now consist of ... new Director of International Sales for,Europe and the ...
... Eli,Lilly and Company and the State of Alaska have ... Talis J. Colberg and Eli Lilly and Company,(NYSE: ... filed by the State,of Alaska over use of Zyprexa(R) ... 3, 2008, in Superior Court in Anchorage., The ...
Cached Medicine News:Health News:Leverage Life's Homework Hotline Is a Resounding Success! 2Health News:New Alzheimer's Disease Survey Reveals Children of Sandwich Caregivers Assist With Loved Ones' Care 2Health News:New Alzheimer's Disease Survey Reveals Children of Sandwich Caregivers Assist With Loved Ones' Care 3Health News:New Alzheimer's Disease Survey Reveals Children of Sandwich Caregivers Assist With Loved Ones' Care 4Health News:New Alzheimer's Disease Survey Reveals Children of Sandwich Caregivers Assist With Loved Ones' Care 5Health News:Mentice, Inc. Announces Appointment of Vice-President, Sales and Marketing, Americas 2Health News:Webcast Alert: Lifeway Foods, Inc. Announces 2007 Year End Full Financial Results 2Health News:Murad Expands International Presence With Appointment of Danny Guez 2Health News:State of Alaska and Eli Lilly and Company Reach Agreement to Settle Zyprexa Lawsuit 2Health News:State of Alaska and Eli Lilly and Company Reach Agreement to Settle Zyprexa Lawsuit 3Health News:State of Alaska and Eli Lilly and Company Reach Agreement to Settle Zyprexa Lawsuit 4Health News:State of Alaska and Eli Lilly and Company Reach Agreement to Settle Zyprexa Lawsuit 5
(Date:9/1/2015)... , September 1, 2015 ... on the basis of sectors, products & services ... globally coupled with the increasing demand of advanced ... expected to propel the growth for bioinformatics market. ... information efficiently is known as bioinformatics. Decreasing cost ...
(Date:9/1/2015)... , Aug. 31, 2015 Research and ... the "Regulatory Affairs for Support Staff (London, UK ... This two day course provides an ... drug development and has been designed specifically for those ... You will gain an overview of EU regulatory procedures ...
(Date:9/1/2015)... LONDON , September 1, 2015 - ... of GARFIELD-AF R egistry data presented ... real-world insights on the evolution of ... -   The first-ever two-year ... showcased at ESC Congress 2015 expose that all-cause death was the most frequent ...
Breaking Medicine Technology:Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 3Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 4Regulatory Affairs for Support Staff Seminar (London, UK - September 24-25, 2015) 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9
... the newest and most advanced automated immunoassay ... AIA-1800 launches with a full menu of ... reproductive, cardiac, and anemia assays. ,The AIA-1800 ... primary tube sampling, auto dilution, auto pretreatment, ...
EZ-PSA is a one-step immunoassay for the rapid, qualitative determination of human Prostate Specific Antigen (PSA) in whole blood. The test is intended for professional use as an aid in the diagnosis...
... name from its first known site of ... of PSA circulates bound to anti-chymotrypsin (PSA-ACT) ... PSA are elevated in patients with prostate ... [1-3]. In addition, PSA serum levels appear ...
... Functional Vision, Quality of Vision and ... both target illumination and glare luminance ... results. Day/Night testing with/without glare and ... and all ANSI standards. All Light ...
Medicine Products: