Navigation Links
New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
Date:6/16/2008

Potential therapy could be the next generation of treatments, researchers say

MONDAY, June 16 (HealthDay News) -- Researchers have identified a new group of compounds that might one day be added to the armamentarium of therapies designed to fight estrogen-fueled breast cancer.

"This is a potential new approach to treating hormonally sensitive tumors," said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. "If it proves to work with a lot of further research, then it does have potential as an important part of cancer research."

The study, by researchers from the University of North Carolina, Chapel Hill, the University of Colorado Health Sciences Center, Denver, and the University of Illinois, Urbana-Champaign, was presented Monday at the annual meeting of the Endocrine Society, in San Francisco.

The molecule, called TPBM, and related drugs may have a role in treating patients who have become resistant to other hormone-based therapies, such as tamoxifen.

"We have a large number of people who have estrogen receptor-positive breast cancer who respond wonderfully to hormone therapy. But, sometimes, after one or two years, the hormone therapy stops working," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La. "[Then] we'll switch to something else. That works for about a year before the cancer progresses. So what is it that's happening in those cancer cells that they become resistant? Perhaps there is another mechanism in which we can try to keep cells in response, and this would perhaps be one of them."

Some two-thirds of all breast cancers are estrogen receptor-positive and therefore respond to hormonal treatments such as tamoxifen or the newer aromatase inhibitors.

Tamoxifen blocks estrogen receptors on breast cancer cells, while aromatase inhibitors interfere with the body's ability to produce estrogen.'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... HealthDay Reporter , THURSDAY, Aug. 28, ... days of the Ebola outbreak in West Africa has given ... Researchers report in the Aug. 28 online issue of ... The Ebola strains responsible for the current outbreak ... first recorded outbreak of Ebola in central Africa in 1976. ...
(Date:8/29/2014)... Winston-Salem, N.C (PRWEB) August 29, 2014 ... 13 awards for excellence in clinical care, honoring nine ... improving the patient experience. , “At Novant Health, providing ... a top priority” said Tom Zweng, MD, executive vice ... continued commitment to provide a remarkable experience for each ...
(Date:8/29/2014)... Bedros Keuilian recently stepped outside his comfort zone to ... the new Spike TV reality show, Gym Rescue. The producers ... an expert in boot camp marketing and Google directed them ... just released a webinar explaining how fitness boot camp owners ... and increase their client base. , In the hour-long ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 "I ... four neck surgeries, as well as many other surgeries in ... inventor from Richmond, Texas. "During my stays, I was unable ... and many other ailments. Two nurses freely had to physically ... stood on either side of me and pulled the sheets. ...
(Date:8/29/2014)... 2014 Gwyneth Paltrow, Beyonce and Angelina Jolie ... have inspired dieters all over the United States, to find ... to help them quickly shed excess fat. And, recent inspiration ... that substitutes all gluten products, eggs and meats for ingredients ... associated with following this type of diet, one must be ...
Breaking Medicine News(10 mins):Health News:Gene Research Yields Insights Into Ebola Virus 2Health News:Gene Research Yields Insights Into Ebola Virus 3Health News:Novant Health Recognized for Excellence in Clinical Care 2Health News:Novant Health Recognized for Excellence in Clinical Care 3Health News:Boot Camp Marketing Expert Bedros Keuilian Releases New Webinar on Using YouTube to Build Credibility and Clientele 2Health News:Boot Camp Marketing Expert Bedros Keuilian Releases New Webinar on Using YouTube to Build Credibility and Clientele 3Health News:InventHelp® Client Develops Equipment for Surgical and Bedridden Patients (HCD-279) 2Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 2Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 3
... Dec. 17 The holiday season is a,great opportunity to ... focus on new goals for the next 12 months. These ... with the,knowledge to become a healthy new you in 2008., ... get healthier is,the best gift you can give yourself this ...
... chronic pain are the leading causes of soldier attrition in ... percent when these soldiers are treated outside the theaters of ... and officers are treated and managed for pain in the ... to a new study from a Johns Hopkins anesthesiologist. , ...
... novel surgical technique allowing doctors to operate on ... stomach could potentially replace certain types of conventional ... researchers who have successfully demonstrated the procedure in ... in human trials, researchers say it could circumvent ...
... without diet changes, study finds , , MONDAY, Dec. 17 (HealthDay ... week is enough to undo metabolic syndrome, a health condition ... new study suggests. , "What we found was a modest ... metabolic syndrome risk," said study author Johanna L. Johnson, a ...
... Two recently released studies confirm an alarming reality, ... screened for colorectal cancer are not. Men and women ... colorectal cancer, but according to a study in the ... Medicare beneficiaries between 1998 and 2004, only 25.4 percent ...
... Congressman John P. Murtha, Chairman of the House Appropriations Subcommittee ... on behalf of veterans blinded by war and for research ... year the Institute gives the Man of Vision Award to ... and the awareness of the challenges of vision loss. Among ...
Cached Medicine News:Health News:AMA: Resolutions for a Healthy New You in the New Year 2Health News:Pain treatment in the field: Good for soldiers' comfort and better for rebuilding troop strength 2Health News:Z-shaped incision enhances minimally-invasive surgery 2Health News:Z-shaped incision enhances minimally-invasive surgery 3Health News:Moderate Exercise Cuts Risk of Metabolic Syndrome 2Health News:Moderate Exercise Cuts Risk of Metabolic Syndrome 3Health News:Recent studies confirm significant underuse of colorectal cancer screening 2Health News:Recent studies confirm significant underuse of colorectal cancer screening 3Health News:Champion of blinded soldiers, Congressman Murtha, is Man of Vision 2
(Date:8/28/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE Amex: ... specializes in patented biopharmaceutical, modernized traditional Chinese medicine ... today updates the timeline for the GMP certification ... The Company is scheduled to submit the ... & Drug Administration,s (CFDA) review in the week ...
(Date:8/28/2014)... SALT LAKE CITY , Aug. 28, 2014 /PRNewswire-iReach/ ... in 2000 by service academy graduates, has published a ... its concentrated, three-day Leadership Excellence Course . In ... the  Leadership Excellence Course to Albuquerque , ... Tucson . Photo - http://photos.prnewswire.com/prnh/20140828/140814 ...
(Date:8/28/2014)... Nonin Medical, Inc., the inventor of finger ... today announced that the Food and Drug Administration (FDA) ... oximeter for use in the United States ... telemedicine hub or kiosk through a USB connector and ... adult patients. The Model 3231 received EU certification last ...
Breaking Medicine Technology:TPI Submits Dataset for GMP Inspection at Qionglai Facility (QLF) 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2
... Xenogenics Corporation ("Xenogenics"), a majority owned subsidiary of ... to announce it has retained the Emmes Group to ... formation strategy to help finance expanded human clinical trials ... testing and initial human use, the Ideal BioStent™ demonstrated ...
... Biosciences, a privately held company leading the development of ... McDonald, MBA, Senior Vice President and Chief Business Officer, ... will highlight new and innovative cardiovascular drug therapies at ... discussion will be held at the New York Palace ...
Cached Medicine Technology:Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 2Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 3Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 4Regado Biosciences to Present at the 2011 RBC Capital Markets Healthcare Conference in New York City 2Regado Biosciences to Present at the 2011 RBC Capital Markets Healthcare Conference in New York City 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: