Navigation Links
New Migraine Gene Discovered
Date:8/30/2010

By Jenifer Goodwin
HealthDay Reporter

SUNDAY, Aug. 29 (HealthDay News) -- Having a particular variation of a gene on chromosome 8 may raise the risk of getting migraines, new research shows.

While migraines have long been believed to have a genetic component, pinpointing specific genes has proven difficult, the researchers said.

The current study is among the first to identify a specific genetic variant associated with a heightened risk for the most common types of migraines, including migraines with and without aura, although the link to migraines with aura was stronger, according to the study.

"We have found this association primarily with migraine with aura. More studies need to be done to verify how widely this is true for other forms of migraine," said senior study author Aarno Palotie, chair of the International Headache Genetics Consortium at the Wellcome Trust Sanger Institute in England.

The study is published in the Aug. 29 issue of Nature Genetics.

Researchers conducteed a genome-wide association study on more than nearly 6,000 people diagnosed with migraine headaches and some 50,000 people without migraines, and found that migraine sufferers were more likely to have a variant on chromosome 8 between the MTDH and the PGCP gene.

The genes are involved with the regulation of the neurotransmitter glutamate, Palotie said.

"When you use genome-wide association studies, you often land in an area that you have no clue what's actually done there," Palotie said. "In this case, we were lucky. Both of these genes are related to the glutamate balance in the body and the brain. We further know that one of these genes regulate an additional gene involved in glutamate regulation."

Glutamate is a chemical, or molecule, that transmit signals between neurons, Palotie said. Researchers speculate the variant might cause glutamate to build up in the synapses, but why a disruption in glutamate levels could contribute to migraines is unknown.

It's also unknown what, in people with a genetic susceptibility, might trigger the headache, he said.

About 26 percent of the migraine sufferers in the study had the variant, while 18 percent to 20 percent of people who didn't have the migraines had it. Though significant, migraines are a complex condition, and many other genes and variants are likely involved.

"What it means is there are many, many more genes that predispose us to migraines," Palotie said. "This one is just uncovering the tip of the iceberg."

About 17 percent of women and 8 percent of men get migraines, according to background information in the article.

Although researchers have in the past described genetic mutations that cause rare forms of migraine, this is one of the first genetic risk factors linked to more common forms of migraines, according to researchers.

Dr. Kate Henry, an associate professor of neurology at New York University Langone Medical, called the findings important in that they uncovered information about the genetics of the most common types of migraines.

"The belief is that about 70 to 80 percent of the risk for migraines is genetic, mainly because we know people with migraine often have people in their families with migraine," Henry said. "But there was never a real clear understanding of what the specific genetics were."

The hope is that a better understanding of the genetics could open the door to safe and more effective treatments, Henry said. Medications such as triptans work for many migraine sufferers, but not all, and they can have side effects. Triptans can also carry added risks for people with cardiovascular disease or risk factors for cardiovascular disease.

About 12 percent to 18 percent of those with migraines have migraine with aura, which can include visual disturbances before the headache starts, and other warning signs that a migraine is imminent.

More information

The U.S. National Institute of Neurological Diseases and Stroke has more on migraines.

SOURCES: Aarno Palotie, M.D., Ph.D., chair, International Headache Genetics Consortium, Wellcome Trust Sanger Institute, Cambridge, England; Kate Henry, M.D., associate professor, neurology, New York University Langone Medical Center, New York City; Aug. 29, 2010, Nature Genetics


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. For Migraine Sufferers, Stigma Adds to Burden
2. Stigma of migraine is significant; worse for those with chronic migraine
3. Migraine sufferers who experienced childhood abuse have greater risk of cardiovascular disease
4. Sleep quality of soldiers with migraine is poor
5. Abnormal brain activity in migraineurs is not restricted to attacks
6. REM sleep deprivation plays a role in chronic migraine
7. Thomas E. Heftler Migraine Research Award
8. New Migraine Drug Might Be Safer for Some
9. Uninsured get poor care for migraine: Harvard study
10. Finding Good Migraine Care a Headache for the Uninsured
11. New Hope for Migraine Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Migraine Gene Discovered
(Date:5/4/2016)... Watsonville, California (PRWEB) , ... May 04, 2016 ... ... powerful formulation of foundational nutrients that supports cellular and metabolic health. This synergistic ... and 400 mg free-form curcumin, along with 150 mg of reduced glutathione and ...
(Date:5/4/2016)... ... , ... Natalie Jill is a well respected lifestyle mentor and ... launch of her new book: Natalie Jill’s 7 Day Jump Start: Unprocess Your Diet ... start a new healthy lifestyle featuring simple recipes using MitoXcell’s raw cacao formula. ...
(Date:5/4/2016)... ... May 04, 2016 , ... Bayco Products has announced the ... dual-light flashlights in models NSP-9842XL and NSR-9844XL . , First previewed at ... uses 2 included CR-123 batteries to produce up to 650 lumens in a ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... ankles, and elbows. Engineered with athletes in mind, OMNIFORCE offers high-performance, less ... ineffective circular knitting, common in the industry) produces premium flat-knit construction with ...
(Date:5/4/2016)... KS (PRWEB) , ... May 04, 2016 , ... ... Transtem™ Patient 2016, a powerful cellular therapy software application that helps blood ... treatments to patients. , Since Transtem’s initial launch, Mediware has continued to enhance ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Research and Markets has ... Myeloma Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Multiple ... Myeloma market valuations and forecast, Multiple Myeloma ...
(Date:5/4/2016)... May 4, 2016 ... the  "Global Acute lymphocytic Leukemia Market and ... their offering.       (Logo: ... Lymphocytic Leukemia Market and Competitive Landscape Highlights ... Leukemia pipeline products, Acute Lymphocytic Leukemia epidemiology, ...
(Date:5/3/2016)... acquired a major investment from Sino-German High-Tech Fund to further expand product development, strengthen its disease modeling capabilities and ... ... ... ... ...
Breaking Medicine Technology: