Navigation Links
New Methods Could Speed Production of Flu Vaccines
Date:5/18/2009

Clinical trials using new strategies show promise for better protection against flu

MONDAY, May 18 (HealthDay News) -- Vaccines made up of virus-like particles (VLPs) could provide stronger and longer-lasting protection against flu viruses than conventional vaccines, researchers say.

Even better, VLP vaccines, which can be grown in cell cultures or plants, can be developed and produced twice as quickly as conventional vaccines, according to research presented May 18 at the 109th General Meeting of the American Society for Microbiology, in Philadelphia.

In early clinical trials, VLP vaccines appear to provide complete protection against both the H5N1 avian influenza virus and the 1918 Spanish influenza virus, said Ted Ross, an assistant professor at the University of Pittsburgh's Center for Vaccine Research.

Adopting the new vaccine strategy may allow public health officials to respond more quickly to emerging influenza pandemics, according to a news release from the American Society for Microbiology.

"The sequence for the recent H1N1 'swine flu' virus was online and available to scientists long before physical samples could be delivered," Ross said in the news release. "It would have been possible to produce VLPs in quantity in as little as 12 weeks, while conventional vaccines require physical samples of the virus, and production can take approximately nine months."

Even without an actual sample of the agent, researchers can generate particles for a vaccine if the genes in the virus have been identified, Ross added.

Injectable vaccines that are currently in use to protect from the seasonal flu consist of three influenza strains that are grown in eggs and then inactivated using chemicals that break the virus up into pieces, according to background information provided in the news release. But because the pieces no longer look like the circulating virus, conventionally produced vaccines do not elicit as strong an immune response as VLPs.

"Virus-like particles look just like a live virus, but they are hollow shells without a genome inside, and they cannot reproduce," Ross said. "Because they look like the virus, they evoke a more robust immune response against the real thing."

Inhaled, mist-based flu vaccines can also elicit a strong immune response, but they are associated with an increased risk of side effects, because they are made with live, attenuated virus, the release noted.

Still, there is disagreement over who should be vaccinated and for what flu viruses, Ross said.

"There is a debate in the influenza community about priming the human population for potential pandemic strains such as H5N1 or 1918," Ross said. "Some researchers advocate adding these strains to the annual flu vaccine. They might not match the next pandemic flu strain exactly, but could provide some protection."

Others contend that it's premature and too costly to vaccinate people against a virus that may never emerge, he said.

More information

The CDC has more on flu vaccines.



-- Jennifer Thomas



SOURCE: American Society for Microbiology, news release, May 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Webcast Alert: Air Methods to Announce First Quarter 2009 Financial Results
2. Long Term Care Alerting Methods Revealed by Industry Leaders
3. Air Methods Preliminary 1st Qtr. Results Exceed Expectations
4. Air Methods Announces Year 2008 Financial Results and Provides First Quarter 2009 Update
5. Air Methods to Report Fourth Quarter and Fiscal Year 2008 Financial Results on Tuesday, March 10, 2009
6. Frost & Sullivan: Novel Diagnostics Methods Driving the European Cancer IVD Market Towards Early Detection and Prevention
7. Early Detection Methods for Pancreatic Cancer Urgently Needed: A Statement From the Pancreatic Cancer Action Network
8. National Patient Advocate Foundation Founder Testifies Before U.S. Senate Health Committee on Methods to Improve Healthcare Quality and Patient Outcomes
9. Air Methods Provides 4th Quarter Update
10. Activator Methods Introduces Web-Based Seminar Program
11. SpectraScience Awarded U.S. Patent 7,469,160 for Its Unique Methods and Apparatus for Evaluating Image Focus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Methods Could Speed Production of Flu Vaccines 
(Date:8/17/2017)... , ... August 17, 2017 , ... ... (ER) on Wednesday, August 16, to community partners. The newly renovated ER was ... Track” area for minor emergencies, eight semi-private rooms to deliver patient results, improve ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... Injury: The Journey to Healing Through Forgiveness ($15.99, paperback, 9781498497626; $7.99, eBook, ... trauma, to encourage inner healing of memories and achieve forgiveness, through a progressive ...
(Date:8/17/2017)... ... ... digital marketing for medical practices, has been recognized as one of the fastest growing privately ... second time in two years. Shawn Miele, Chief Executive Officer of Advice Media, said, “We ... a row. It’s extremely difficult to make this list once. The fact that we made ...
(Date:8/16/2017)... ... ... Summer days spent with family are priceless. Since August is Family Fun ... the season of sunshine. Add trying something new to this summer’s bucket list. Whether ... the fun. , Try Something New , Choose an activity the ...
(Date:8/16/2017)... , ... August 16, 2017 , ... Ten outstanding teachers ... Stars in the Classroom and will win a visit by a Houston Texans player, ... who are at least five years old can visit texanschecking.com/stars to nominate their favorite ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... July 27, 2017  Zimmer Biomet Holdings, Inc. (NYSE ... ended June 30, 2017.  The Company reported second quarter ... over the prior year period, and an increase of ... basis points of contribution from the LDR Holding Corporation ... second quarter of 2016, or 0.3% on a constant ...
(Date:7/26/2017)... Aesthetics, a leading medical aesthetic clinic in Singapore ... skin conditions from the inside. The natural process of ... skin becomes more transparent due to the thinning of the epidermis. Over ... the sun contributes to aging skin, causing age spots and other ... ...
(Date:7/25/2017)... Spain and CAMBRIDGE, Massachusetts , ... Biotech, specializing in repurposing drugs to treat rare nervous system ... Inc. to clinically develop and market the drug SOM0226 against ... the drug achieved very promising results in a Phase 2 ... A new office in the United States ...
Breaking Medicine Technology: