Navigation Links
New Melanoma Drug May Extend Survival
Date:6/25/2012

MONDAY, June 25 (HealthDay News) -- New research suggests that a new drug does a better job of combating advanced skin cancer in melanoma patients than chemotherapy.

However, patients typically still got worse after only a few months on the drug.

The drug, called dabrafenib, blocks a signaling protein and is used to treat melanomas with a specific genetic mutation. About half of melanoma patients have this mutation.

In a phase 3 trial funded by the drug's maker, GlaxoSmithKline, an international group of researchers led by Dr. Axel Hauschild of the Schleswig-Holstein University Hospital in Kiel, Germany, gave dabrafenib or the most common existing treatment, dacarbazine (DTIC-Dome), to 250 patients with spreading or inoperable melanoma. About half responded partially (47 percent) or fully (3 percent) to dabrafenib; the response rate among the dacarbazine group was just 6 percent.

Those who took the new drug survived for an average of 5.1 months without getting worse; 2.7 percent of those treated with the existing drug did the same.

The study authors report that the new drug had few side effects, and those related to the skin appeared to be less severe than in patients on a similar drug called vemurafenib (Zelboraf). That drug is now available in the United States.

It's not clear if the drug will affect overall survival rates. "This trial is good news for our patients with metastatic melanoma. Competition in the field is appreciated since it accelerates new clinical trials, particularly in the combinational setting," Hauschild said in a news release from The Lancet, which published the study online June 25.

"This trial is a major step forward in the run for an improvement of the survival for this disease, which was thought to be untreatable for decades," he added.

Dr. Vernon K. Sondak, chair of the department of cutaneous oncology at the Moffitt Cancer Center in Tampa, said treatments for melanoma have been lacking. New so-called "targeted" drugs like dabrafenib have shown promise, he added, "but all these targeted therapies have a weakness, and that is the eventual development of resistance in the tumor cells."

Still, the research into various drugs "opens up new possibilities for combination therapies that may be even more effective, potentially without causing increased side effects," he said.

As for cost, Sondak said melanoma treatments have been so expensive that health agencies in some countries have refused to pay for them.

More information

For more about melanoma, try the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Vernon K. Sondak, M.D., surgeon and chair, department of cutaneous Oncology, Moffitt Cancer Center, Tampa; June 25, 2012, The Lancet, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Surgery Rates Rising for Non-Melanoma Skin Cancer: Study
2. Moffitt Cancer Center researchers working at frontiers of melanoma research
3. Women More Likely to Survive Melanoma Than Men: Study
4. Scientists Map Melanomas Genome
5. Two-Drug Combo May Be Safe for Melanoma Treatment
6. Melanoma a Big Threat to Older Men
7. Fish shed light on human melanoma
8. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
9. Healthy Behaviors Extend Life After Cancer, Experts Say
10. Exercise and a healthy diet of fruits and vegetables extends life expectancy in women in their 70s
11. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Melanoma Drug May Extend Survival
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a dash of ... for strength training and exercise or simply lifting heavy objects, advises Dr. Kaliq Chang, ... everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an attempt to ...
(Date:5/23/2017)... ... May 23, 2017 , ... Allegheny Health Network and ... Joy D’Achille Center for Women’s Behavioral Health at West Penn Hospital , a ... for women suffering from pregnancy-related depression. Construction of the Center is underway with ...
(Date:5/23/2017)... ... May 23, 2017 , ... i2i ... 2017 Best in KLAS category winner, has named Daniel P. Bullington as chief ... enhance its technology platform and product offerings,” says Justin Neece, president. “Daniel is ...
(Date:5/23/2017)... , ... May 23, 2017 , ... By all indications, ... in Sonoma County. While officials call for diligence, asking homeowners to scout for any ... potential health concerns. Along with the annoying buzz of mosquitos is the buzz associated ...
(Date:5/23/2017)... Charleston, SC (PRWEB) , ... May 23, 2017 , ... ... from Dr. Kevin Hogan, an experienced dentist practicing in Mt. Pleasant, SC, with or ... and is often recommended for patients with missing teeth in Charleston, SC. ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)...  May is Stroke Awareness Month and Omron Healthcare ... methods to prevent a stroke: monitor and manage your ... and Prevention, undetected and uncontrolled hypertension is a leading ... leader in personal heart health technology, recently evolved its ... and stroke and is advancing a national public education ...
(Date:5/4/2017)... and SAN DIEGO , May 4, ... (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP Medical ... medical devices, today announced the launch of a new ... OfficeSPEC and ER-SPEC vaginal specula. Already ... extra-small and extra-large sizes makes OBP Medical,s line of ...
(Date:5/3/2017)... , May 3, 2017  Kalorama Information notes ... nine percent next year and this is projected ... hematopoietic stem cell (HSCT) or bone marrow transplants ... technologies are well-suited for this task. This according ... publisher Kalorama Information. The various PCR-based methodologies, Sanger ...
Breaking Medicine Technology: