Navigation Links
New Medicine Might Fight Drug-Resistant TB, Study Says
Date:6/6/2012

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, June 6 (HealthDay News) -- More than four decades after the last introduction of fresh treatments for tuberculosis, a new medication for multidrug-resistant strains of the global scourge has shown promise in a multinational trial.

Scientists in nine countries tested delamanid -- which inhibits the production of mycolic acid, a key component of tuberculosis (TB) bacteria. In a phase 2 trial with 481 patients, the drug cleared TB from the sputum cultures of nearly half the patients within two months, the study said.

"I think it's very important that we have, in delamanid, the potential for a new drug in the first class of new drugs in 40 years," said study co-author Lawrence Geiter, vice president of global clinical development for Otsuka Pharmaceutical Co., the Tokyo-based developer of delamanid. "It's going to enhance treatment options."

The study is published June 7 in the New England Journal of Medicine.

Considered one of the world's deadliest infectious diseases, TB or its complications kill about 1.5 million people globally each year. The World Health Organization (WHO) estimates that nearly 5 percent of all TB cases worldwide are multidrug-resistant, with 440,000 cases occurring annually. If first-line drugs such as rifampin and isoniazid fail, second-line drugs must be taken for up to two years, and a cure is far from guaranteed.

Though TB rates fell to an all-time low in the United States in 2011, the U.S. Centers for Disease Control and Prevention found that infection rates were seven times higher for Hispanics, eight times higher for blacks and 25 times higher for Asians than whites.

"Any time you can add a new TB drug with a novel mechanism that kills bacteria, it's an important advance," said Dr. Eric Nuermberger, an associate professor of medicine at the Center for Tuberculosis Research at Johns Hopkins University School of Medicine, in Baltimore. "Drug-resistant TB is becoming a huge global crisis, and this study proves that this drug . . . has the potential to improve our current regimens. We can all sit and speculate about the margin of improvement, but this proves that it's active nonetheless."

Study participants, who were between 18 and 64 years old, were randomly assigned to one of three equal groups, including two groups that were administered different daily doses of delamanid and a third that received a placebo. All three groups also took a background drug regimen developed according to WHO guidelines.

After eight weeks of treatment, about 45 percent of patients receiving 100 milligrams (mg) of delamanid twice daily were clear of TB bacteria in sputum cultures, as were nearly 42 percent of those receiving 200 mg of delamanid twice daily. This rate was only about 30 percent for those in the placebo group.

A potentially concerning side effect of delamanid treatment was a change in the heart's electrical activity known as QT prolongation, which showed up on electrocardiograms but did not produce cardiac symptoms such as dizziness or heart arrhythmias. Geiter said phase 3 studies of the drug will continue to monitor the effect. Otsuka has applied for drug approval in the European Union but not yet in the United States, he added.

Nuermberger noted that several new TB drugs under development have the potential to affect the heart, "so the real concern is about the additive effects" should these drugs be used in combination with each other.

"Those things are going to have to be sorted out," Nuermberger said. "These are the types of problems that don't tend to show up in a phase 2 study . . . even when they are effects on the EKG, as described here, death and arrhythmias are relatively infrequent. But when you apply them on a global basis, it can become important."

"While it's a critical advance, there still a tremendous amount of work that needs to be done to combine [delamanid] with existing agents . . . and turn the tide," added Nuermberger, who co-authored a commentary on treatments for multidrug-resistant TB in the same journal issue.

More information

The U.S. Centers for Disease Control and Prevention has more about multidrug-resistant TB.

SOURCES: Lawrence Geiter, Ph.D., M.P.H., vice president, Global Clinical Development, TB, Otsuka Novel Products, Tokyo; Eric L. Nuermberger, M.D., associate professor, medicine, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore; June 7, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. Embargoed News from Annals of Internal Medicine
4. New Gallup Poll Quantifies U.S. Physician Opinions on the Scope of Defensive Medicine Practices
5. What's the Cost of Defensive Medicine?
6. Doctors Practice Medicine in Fear, New Study Finds
7. Cancer patients find relief in integrative medicine services
8. The most frequent error in medicine
9. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
10. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
11. Tort Reform Does Not Eliminate Defensive Medicine Practices, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Medicine Might Fight Drug-Resistant TB, Study Says
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... system that we intend to develop to enable prevention of a major side ... severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
Breaking Medicine Technology: