Navigation Links
New Mayo Clinic approach could lead to blood test to diagnose Alzheimer's in earliest stage
Date:5/29/2013

ROCHESTER, Minn. -- Blood offers promise as a way to detect Alzheimer's disease at its earliest onset, Mayo Clinic researchers say. They envision a test that would detect distinct metabolic signatures in blood plasma that are synonymous with the disease -- years before patients begin showing cognitive decline. Their study was recently published online in the journal PLOS ONE.

Researchers analyzed cerebrospinal fluid and plasma samples from 45 people in the Mayo Clinic Study on Aging and Mayo Clinic Alzheimer's Disease Center (15 with no cognitive decline, 15 with mild cognitive impairment and 15 with Alzheimer's disease). They detected significant changes in the cerebrospinal fluid and plasma in those with cognitive decline and Alzheimer's. Most important, changes in plasma accurately reflected changes in the cerebrospinal fluid, validating blood as a reliable source for the biomarker development.

The team uses a relatively new technique called metabolomics, which measures the chemical fingerprints of metabolic pathways in the cell -- sugars, lipids, nucleotides, amino acids and fatty acids -- to detect the changes. Metabolomics assesses what is happening in the body at a given time and at a fine level of detail, giving scientists insight into the cellular processes that underlie a disease. In this case, the metabolomic profiles showed changes in metabolites related to mitochondrial function and energy metabolism, further confirming that altered mitochondrial energetics is at the root of the disease process.

The researchers hope that identified changes in the metabolic pathways could lead to the panel of biomarkers, which can eventually be used on a larger scale for early diagnosis, monitoring of Alzheimer's progression, and evaluating therapeutic approaches, says co-author Eugenia Trushina, Ph.D., a Mayo Clinic pharmacologist.

"We want to use these biomarkers to diagnose the Alzheimer's disease before symptoms appear -- which can be decades before people start exhibiting memory loss," Dr. Trushina says. "The earlier we can detect the disease, the better treatment options we will be able to offer."


'/>"/>

Contact: Nick Hanson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. CureLauncher Introduces Personalized Clinical Trial Matching Service
2. Pain Management and Chiropractic Clinic Announces New Treatment
3. Atlanta Vision Clinic Acquires the Latest in Blade-Free Lasik Technology Bringing Dubai Patients the Intralase Method
4. Mayo Clinic genomic analysis lends insight to prostate cancer
5. Vancouver Skin Care Clinic Successfully Clears Pigmentation in Skin of Colour
6. CareAnyware and Cornell University Partner to Help Reduce Rehospitalizations by 39% in Clinically Depressed Home Health Patients
7. Pittsburgh Riverhounds Host First-Ever Watson Institute Special Kick Clinic
8. Find Urgent Care Launches New Site Design and Functionality to Provide Advanced Search Options for Users in Need of an Urgent Care Clinic
9. Two-day San Jose Dental Clinic Provides More Than $1.6 Million in Care
10. Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld
11. Clearview Treatment Programs Clinical Director to Present on DBT and Substance Abuse at WCSAD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Texas Premier Locksmith ... carried out by unethical locksmith companies and is urging Search Engines to improve ... to Texas Premier Locksmith, these fraudulent locksmith services take advantage of consumers locked ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... "ProBrand Flip ... and all media," said Christina Austin - CEO of Pixel Film Studios. , ProBrand ... easy to use drop zones. Editors can select from a variety of flip book ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... Infertility and Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin ... has a team of three acupuncturists to help patients realize their family building ...
(Date:12/7/2016)... ... December 07, 2016 , ... “Walking With God: Inspirational ... that will inspire the reader to be aware of God's direction in their lives. ... author, Sanford Smith, retired teacher and active church leader. , Sanford says, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... annual Business Architecture Innovation Summit in Reston, VA on March 21-22, 2017. This ... share a range of experiences from a cross-section of industries such as financial ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... NORTH READING, Mass. , Dec. 7, 2016 ... Track and Trace Network for connecting the Life ... from the global marketplace, today announced that Tjoapack ... 50+ European pharmaceutical manufacturing customers comply with the ... Supply Chain Security Act (DSCSA) in 2017 and ...
(Date:12/7/2016)... 7, 2016  Varian Medical Systems (NYSE: ... announced plans to separate its Imaging Components business.  The ... distribution to Varian stockholders of common stock in Varex ... hold the Imaging Components business.  As part of the ... the end of January 2017, Varian will receive an ...
(Date:12/7/2016)... 7, 2016  Organovo Holdings, Inc. (NASDAQ: ... focused on delivering scientific and medical breakthroughs using ... and Chief Executive Officer Keith Murphy ... December 14, 2016 at 1:00 p.m. Eastern Time ... yet familiar with the Company, an informational video ...
Breaking Medicine Technology: