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New MRI technique may predict progress of dementias
Date:4/10/2012

A new technique for analyzing brain images offers the possibility of using magnetic resonance imaging (MRI) to predict the rate of progression and physical path of many degenerative brain diseases, report scientists at the San Francisco VA Medical Center and the University of California, San Francisco.

The technique, developed by SFVAMC scientists in collaboration with a team led by Bruce Miller, MD, clinical director of the UCSF Memory and Aging Center, also supports mounting evidence that dementias spread through the brain along specific neuronal pathways in the same manner as prion diseases (see related UCSF story).

The scientists employed new computer modeling techniques to realistically predict the physical progression of Alzheimer's disease and frontotemporal dementia (FTD) using images of 14 healthy brains. The models were based on whole-brain tractography, an MRI technique that maps the neural pathways, or "communication wires," that connect different areas of the brain. The spread of disease along those pathways, as predicted by the models, closely matched actual MRI images of brain degeneration in 18 Alzheimer's patients and 18 FTD patients. Their study was published in the March 22 edition of Neuron.

"The results need to be replicated, but they suggest that, by using this approach, we can predict the location and course of future brain atrophy in Alzheimer's, FTD and other degenerative brain diseases, based on just one MRI taken at the outset of the disease," said senior author Michael Weiner, MD, director of the SFVAMC Center for Imaging of Neurodegenerative Diseases. "This would be extremely useful in planning treatment, and in helping patients and families know what to expect as dementia progresses."

Weiner, who is also a UCSF professor of radiology, medicine, psychiatry and neurology, said that the results were "consistent with an emerging concept that brain damage occurs in these neurodegenerativ
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Contact: Steve Tokar
steve.tokar@ncire.org
415-221-4810 x5202
University of California - San Francisco
Source:Eurekalert  

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