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New KLRI Reports Shows Longevity Science Moving Beyond Studying the Obvious to the 'Downward Spiral' Paradigm in the Aging Process
Date:6/10/2008

Slowing down the interrelated effects of biomarkers most promising way to help older adults live long, vigorous lives

PHOENIX, June 10 /PRNewswire-USNewswire/ -- The Kronos Longevity Research Institute (KLRI) has released the 2008 State of the Science, which examines "the vicious triad" of the aging process: oxidative stress, hormonal changes, and nutrition and its effects on age-related deteriorations and diseases. Longevity scientists across the country are studying how the inter-related, degenerative processes of aging contribute to the downward spiral in health and aging.

"Once we identify the relationships of the contributors to aging and age-related deterioration and diseases, we can begin to develop ways to slow down or even reverse the aging process," says KLRI Director and President S. Mitchell Harman, MD, PhD. "Rather than investing only in cures, we should invest more in prevention. This is the smart approach to help the growing numbers of older adults in this country stay independent, healthy and active for as long as possible."

Oxidative stress accounts for much of the wear and tear in the body. KLRI and KLRI-affiliated researchers have developed methods to accurately measure oxidative stress biomarkers in the urine and blood. Now, using a unique process that safely creates oxidative stress in healthy humans, they are working to establish a reference range for people ages 20 to 85 to determine what is "normal" in different age groups.

Animal studies have found that dramatically reducing food intake, or caloric restriction, can significantly increase longevity. A major initiative in longevity science is trying to identify compounds that produce the same biochemical effects without limiting the amount of food.

Along with oxidation and caloric restriction, the impact of hormones is a key focus in longevity science. KLRI researchers have launched a national, multi-center study to evaluate the effects of estrogen the
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SOURCE Kronos Longevity Research Institute
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