Navigation Links
New JNM research supports upcoming Alzheimer's disease guidelines
Date:8/1/2011

Reston, Va. (August 1, 2011) Two new studies published in the August issue of The Journal of Nuclear Medicine (JNM) provide insight into the potential of positron emission tomography (PET) to differentiate between types of dementia and to identify pharmaceuticals to slow the progress of dementia. With proposed National Institute on Aging (NIA) and the Alzheimer's Association guidelines for detecting Alzheimer's-related brain changes expected in September, these articles give a preview of what may be to come.

Earlier this year, the NIA and the Alzheimer's Association released new criteria and guidelines for the diagnosis of Alzheimer's disease. The new proposed guidelines available this fall will offer additional information regarding the development of tests to measure biological changes in the brain, blood, or spinal fluid to diagnose Alzheimer's at an earlier stage.

Earlier diagnosis of Alzheimer's disease is the focus of the JNM article "Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias." In this study researchers compared cortical amyloid deposition using 18F-florbetaben and PET in 109 controls and subjects with mild cognitive impairment (MCI), frontotemporal lobar degeneration, dementia with Lewy bodies, vascular dementia, Parkinson's disease and Alzheimer's disease.

The results show that 18F-florbetaben performs with the same high accuracy as previously reported with 11C-Pittsburgh Compound Bthe most specific and widely used amyloid imaging agentfor distinguishing between certain types of neurodegenerative dementia, particularly for diagnosis of Alzheimer's disease from frontotemporal dementia.

"The difference between 11C-Pittsburgh Compound B and 18F-florbetaben is that the 18F-florbetaben has a longer half life and is more affordable, making it appropriate for clinical use," said Christopher Rowe, MD, FRACP, one of the authors of the study. "This distinction profoundly affects treatment and prognosis and has genetic implications for the family."

In addition to detecting Alzheimer's disease earlier, molecular imaging can also be used in clinical trials to help develop pharmaceuticals to prevent or delay the onset of dementia. This is particularly of importance to patients with MCI who have yet to develop Alzheimer's disease.

"We urgently need tools for conducting drug trials for MCI more efficiently," noted Karl Herholz, MD, lead author of the study "Evaluation of a Calibrated 18F-FDG PET Score as a Biomarker for Progression of Alzheimer's Disease and Mild Cognitive Impairment." He continued, "Clinical outcome parameters show large variability and little sensitivity to progression at that stage, making these trials extremely costly and cumbersome. By using imaging biomarkers as primary outcome parameters, clinical trials can be performed with smaller sample sizes or shorter trial duration without loss of study power."

The study evaluated a predefined quantitative measurea PET scorethat was extracted automatically from 18F-FDG PET scans using a sample of controls, patients with MCI and patients with Alzheimer's disease. The PET scores provided a much higher test-retest reliability than standard neuropsychologic test scores (Alzheimer's Disease Assessment Scale-Cognitive and Mini-Mental State Examination) and superior strength for measuring progression, as well as a valid measurement of cognitive impairment. As such, the PET scores can be considered a valid imaging biomarker to monitor the progression of MCI to Alzheimer's disease.

"Prevention of dementia by drugs applied at MCI stage would greatly improve quality of life for patients and reduce costs of dementia care and treatment. Thus, development of such drugs and efficient tools for testing them are extremely important," concluded Herholz.


'/>"/>

Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. New CMU brain imaging research reveals why autistic individuals confuse pronouns
2. Obesity counseling should focus on neurobehavioral processes, not personal choice, researchers say
3. UofL School of Nursing researcher plans to build on successful aging theory
4. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
5. NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
6. Johns Hopkins researchers discover how some breast cancers alter their sensitivity to estrogen
7. Conference: Improving K-12 education with cutting-edge cognitive neuroscience research
8. Refocusing the boom in biomarker research
9. Researchers aim for direct brain control of prosthetic arms
10. Researchers work to take the pressure off newborns lungs
11. Research discovers genetic link to Barretts esophagus, esophageal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... ... Michael and Betsy Brauser celebrated 5 years of Betsy’s participation in a ... has been life-saving as she has been on the trial for more than six ... ovarian cancer in 2009. She underwent standard chemotherapy but a year later went to ...
(Date:1/20/2017)... ... , ... “Mary Magdalene: Grace is Greater than Sin”: a unique and ... Christ firsthand. “Mary Magdalene: Grace is Greater than Sin” is the creation of published ... with countless women who had little knowledge of the female characters portrayed in the ...
(Date:1/20/2017)... ... January 20, 2017 , ... “I Forgive You”: a fine examination of how ... You” is the creation of published author, Stephen Miller, who, for over ten long years ... given to him. Born in Trinidad and Tobago, he has been serving the Lord for ...
(Date:1/20/2017)... ... ... and enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is ... a devoted woman of faith. , “Becoming a parent changes you. In my case, ... for years, but actually doing it might have been a while in coming if it ...
(Date:1/20/2017)... ... 2017 , ... “God's Miracle Man: Against All Odds”: an inspiring affirmation ... author, Keith C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native ... Mark Hardy , “While sitting up in bed, I felt a pounding headache. It ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 Report Details ... Devices Market? Which areas are going to grow at ... revenues to 2026, assessing data, trends, opportunities and prospects. ... graphs. Discover the most lucrative areas in the industry ... you assess forecasted sales across the all the major ...
(Date:1/19/2017)... WASHINGTON , Jan. 19, 2017 Conference Call and ... VNDA ) today announced it will release results for the ... market closes. ... Vanda will host a conference call at 4:30 PM ET on ... quarter and full year 2016 financial results and other corporate activities. ...
(Date:1/19/2017)... 19, 2017 Many patients don,t realize that ... when a pharmacy just a few blocks away charges ... this problem Medicationdiscountcard.com has created a price ... how much their medication will cost at most nearby ... Medicationdiscountcard.com takes all of ...
Breaking Medicine Technology: