Navigation Links
New Injection Might Lower Tough-to-Treat Cholesterol
Date:3/26/2012

By Steven Reinberg
HealthDay Reporter

MONDAY, March 26 (HealthDay News) -- Researchers report that injections of a novel "monoclonal antibody" lowered LDL cholesterol levels in patients with high cholesterol by as much as 72 percent.

This new treatment could help lower levels of "bad" cholesterol for the one in five people who don't respond to the commonly prescribed cholesterol-lowering drugs known as statins. It may also be helpful in patients who can't get their cholesterol low enough with statins alone, the researchers added.

"If this pans out, it will be a whole new approach to lowering cholesterol," James McKenney, chief executive officer of National Clinical Research Inc., said during a Monday press briefing at the American College of Cardiology annual meeting in Chicago, where the research was to be presented. A report on the findings was published simultaneously in the Journal of the American College of Cardiology.

The experimental compound appeared to lower LDL cholesterol by making it easier for the liver to remove LDL cholesterol from the bloodstream, McKenney said. Monoclonal antibodies are antibodies cloned from a single cell, which are all identical because they are cloned, the researchers explained.

The study was funded by the drug's manufacturers: Sanofi U.S. and Regeneron Pharmaceuticals. The research company that McKenney works for has also received funding from both drug makers.

For this phase 2 study, McKenney's team randomly assigned 183 patients with high cholesterol who had been treated with Lipitor (atorvastatin) for more than six weeks, to one of six groups.

Three groups were given injections of the new drug in high, medium or low doses every two weeks. Two other groups were given very high doses of the drug every four weeks. The sixth group received a placebo.

After 12 weeks, the researchers found those who received the low dose of the monoclonal antibody saw their LDL levels drop by 40 percent. For those given the medium dose, LDL levels decreased 64 percent while those given the high dose saw their cholesterol levels drop by 72 percent.

For those in the two groups taking very high doses every four weeks, the drops in LDL cholesterol were 43 percent and 48 percent, the researchers said.

McKenney noted there is a long way to go and much more research is needed before this drug is ready for public use. Since it would need to be taken regularly, he see it as akin to insulin where the patient can inject the drug in measured doses.

In terms of cost, it's far too early to say what a patient would have to spend for this therapy, the researchers said.

Longer trials are planned. The study authors said they feel confident that the drug is safe and effective, but they need to confirm the results over the long-term.

Dr. Gregg Fonarow, director of the Ahmanson UCLA Cardiomyopathy Center and co-director of the UCLA Preventative Cardiology Program, said that "statin therapy has been remarkably effective in reducing fatal and nonfatal cardiovascular events."

Yet, many patients cannot achieve optimal reduction in LDL cholesterol levels with statins and some patients do not tolerate statins well, he noted.

"This novel, new therapy is exceptionally promising," Fonarow said. "Achieving LDL cholesterol reductions of up to 72 percent on top of statin therapy is very impressive."

"If further studies demonstrate the long-term safety, efficacy and effectiveness of this therapy, this will represent a tremendous advance in preventing and treating cardiovascular disease, which has remained the leading cause of premature death and disability in men and women," Fonarow added.

Results of another study also due to be presented Monday suggest that starting statin therapy early in life might significantly reduce the risk for heart disease.

Rather than actually treating patients with statins, the researchers used a type of study that looks at changes in DNA that, in this case, were linked to lower levels of cholesterol.

Since one has these mutations at birth, it's like being blessed with naturally low cholesterol. These mutations stand in for statin therapy, lead researcher Dr. Brian Ference, director of the cardiovascular genomic research center at Wayne State University School of Medicine in Indiana, said during Monday's press conference.

"This research is a way of finding out the effects of lowering cholesterol early without having a lengthy clinical trial," Ference said.

The researchers looked at genes from participants of several studies, one including more than 350,000 patients, and found nine specific mutations.

For each single measure of reduced lifetime exposure to LDL cholesterol associated with having the mutations, the researchers found a 50 percent to 60 percent reduction in heart disease risk.

Because the second study was presented at a medical meeting, its conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

For more about cholesterol, visit the U.S. National Library of Medicine.

SOURCES: Gregg C. Fonarow, M.D., director, Ahmanson UCLA Cardiomyopathy Center, co-director, UCLA Preventative Cardiology Program; March 26, 2012, press briefing with: James McKenney, Pharm.D, chief executive officer, National Clinical Research Inc.; Brian A. Ference, M.D., director, cardiovascular genomic research center, Wayne State University School of Medicine, Detroit; March 26, 2012, presentations, American College of Cardiology annual meeting, Chicago; March 26, 2012, Journal of the American College of Cardiology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Steroid injections prove effective in treatment of lumbar disc herniations
2. Bath-Salts Injection Leads to Flesh-Eating Disease
3. Study Questions Use of MRI Before Back-Pain Injections
4. Toronto-based genomics center gets $5 million injection
5. Illegal Silicone Buttock Injections Can Be Deadly: Experts
6. Foam injections for varicose veins better for patients and cheaper, study finds
7. Researchers successfully perform first injection of cultured red blood cells in human donor
8. Injection Drug Users Most in Need of Treatment, Study Says
9. Physician participation in lethal injection executions should not be banned, argue 2 ethicists
10. Most nurses dont use recommended intramuscular injection site despite potential risks
11. Deaths from drug overdose decline 35 percent after the opening of supervised injection site
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Injection Might Lower Tough-to-Treat Cholesterol
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Consumers have taken a ... have placed more emphasis on patient outcomes. ... programs in the pharmaceutical industry have evolved beyond ... pharmaceutical companies are focusing on becoming more patient-oriented ... products and services that improve health. ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
Breaking Medicine Technology: