Navigation Links
New IOF review provides guidance on fracture prevention in cancer-associated bone disease
Date:11/1/2013

Nyon, Switzerland November 1, 2013

Cancer is a health burden of increasing importance which affects close to 13 million people globally. Bone is often affected in these patients, frequently because of bone metastases, or as a result of anti-cancer therapies which can contribute to bone loss and fragility.

A new paper published by an International Osteoporosis Foundation (IOF) Committee of Scientific Advisors Working Group reviews the epidemiology and pathophysiology of cancer-associated bone disease and provides information about fracture prevention in cancer patients. The review summarizes the pertinent recommendations of leading societies, providing guidance for clinical decision making and information on evidence-based pathways to prevent skeletal-related events and bone loss.

Cancer patients are at greater risk of bone disease and fractures:

Cancer-induced bone disease can result from the primary disease itself, either due to circulating bone resorbing substances, or from metastasis to bone such as commonly occurs with breast, lung and prostate cancer. As well, cancer therapy itself can cause bone loss and fractures especially in the case of glucocorticoid or estrogen deprivation therapy, chemotherapy-induced ovarian failure, and androgen deprivation therapy.

As people with cancer survive longer, cancer related bone disease and its treatment becomes an important health issue that needs to be addressed. For example, women undergoing therapy for breast cancer, without bone metastases, have been shown to have a fivefold higher prevalence of vertebral fractures than women without cancer of the same age. Men with prostatic cancer are at particularly high risk of osteoporosis and fracture due in part to treatment with androgen deprivation therapy. Rates of bone mineral density decrease can be as high as 3 to 5.6% within the first year of treatment alone.

Professor Ren Rizzoli, lead author and Professor of Medicine and Head of the Division of Bone Disease at the University Hospitals of Geneva stated, "Physicians must make a concerted effort to prevent bone loss and fractures in their patients. Fragility fractures due to osteoporosis can have serious repercussions, including severe pain, immobility, and accompanying loss of quality of life. Patients with cancer, including those who are in remission, should not have their quality of life further jeopardized by disability resulting from fractures."

Early evaluation and treatment for osteoporosis is critical:

Physicians should be aware that cancer patients are at heightened risk of fractures, and that bone-modifying agents, such as bisphosphonates and denosumab, are effective in preventing and delaying cancer-related bone disease.

"Recommendations for assessment and treatment with bone modifying therapies are highly targeted to the type of cancer, and depend on whether or not bone metastasis is involved and whether the bone loss is treatment induced. This IOF review gives physicians a comprehensive understanding of the key clinical considerations involved and directs attention to the recommendations of the expert societies in the field," said Professor Cyrus Cooper, Chair of the IOF Committee of Scientific Advisors.


'/>"/>

Contact: L. Misteli
info@iofbonehealth.org
41-229-940-100
International Osteoporosis Foundation
Source:Eurekalert

Related medicine news :

1. Omega-3 Supplements No Help Against Repeat Heart Trouble: Review
2. AADR comments on review that validates association between oral health and heart health
3. IUDs Work as Emergency Contraceptive: Review
4. ICU stays for worst asthma drop 74 percent, review finds
5. Antiretroviral treatment for preventing HIV infection: an evidence review for physicians
6. TheBestHeartRateMonitorReviews.com Announces The Top 3 Heart Rate Monitors
7. US Drug Watchdog Now Offers To Get A Free Legal Review For All DePuy ASR Recipients Who Received A Letter From Broadspire About Their Recalled DePuy Hip Implant
8. University of Nevada School of Medicine researcher reviews muscular dystrophy therapies
9. Metabolic Cooking Review For Karine Losier and Dave Ruel's Diet And Cookbook Program Released
10. Waterpik Water Flosser Reviews Released Today By WaterpikReviews.net
11. GMC Denali Road Bike Review Released Today By GMCDenaliRoadBike.net
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... FL (PRWEB) , ... February 10, 2016 , ... AxoGen, ... market, will report results for the fourth quarter and full year ended December 31, ... host a conference call and webcast for the investment community following the release at ...
(Date:2/10/2016)... ... February 10, 2016 , ... AHRA: The ... and inspirational speaker Jan Fox will serve as keynote speaker at the organization’s ... participants with tools to more effectively communicate with their own organizational staff and ...
(Date:2/10/2016)... ... February 10, 2016 , ... For additional information contact Phyllis Strupp ... book "Better with Age: The Ultimate Guide to Brain Training" by award-winning author ... The book’s publication date is March 16, 2016. A free review copy is ...
(Date:2/10/2016)... Beach, Florida (PRWEB) , ... February 10, 2016 ... ... Country Club) announced that it has been awarded the prestigious Distinguished Emerald Club ... World award program conducted by BoardRoom magazine, one of the most respected trade ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... biocompatible columns and accessories. These PEEK-lined stainless steel (PLS) columns combine the strength ... solution that ensures the integrity of biological samples while operating at ultra-high pressures ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Urologix, the market leader for in-office minimally invasive ... (BPH), announces new private ownership and is operating as ... industry veteran of more than 20 years, has been ... Plymouth, Minn. The company,s two ... RF Therapy, will continue to be broadly available and ...
(Date:2/10/2016)... Feb. 10, 2016  Rich Pharmaceuticals, Inc. (OTC Markets: ... 1-for-100 reverse split of its issued and outstanding shares ... on Thursday, February 11, 2016. The Company,s common stock ... number 76303T308 and temporary ticker symbol "RCHAD". After 20 ... the ticker symbol (RCHA).  --> ...
(Date:2/10/2016)... 10, 2016  Oxis International Inc. (OTC/QB: OXIS) announced ... described as a "clinical trial triumph" after one of ... complete cancer remission. Daniel Vallera , ... Cancer Center. --> Daniel Vallera , ... Cancer Center. --> An article on ...
Breaking Medicine Technology: