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New IOF review provides guidance on fracture prevention in cancer-associated bone disease
Date:11/1/2013

Nyon, Switzerland November 1, 2013

Cancer is a health burden of increasing importance which affects close to 13 million people globally. Bone is often affected in these patients, frequently because of bone metastases, or as a result of anti-cancer therapies which can contribute to bone loss and fragility.

A new paper published by an International Osteoporosis Foundation (IOF) Committee of Scientific Advisors Working Group reviews the epidemiology and pathophysiology of cancer-associated bone disease and provides information about fracture prevention in cancer patients. The review summarizes the pertinent recommendations of leading societies, providing guidance for clinical decision making and information on evidence-based pathways to prevent skeletal-related events and bone loss.

Cancer patients are at greater risk of bone disease and fractures:

Cancer-induced bone disease can result from the primary disease itself, either due to circulating bone resorbing substances, or from metastasis to bone such as commonly occurs with breast, lung and prostate cancer. As well, cancer therapy itself can cause bone loss and fractures especially in the case of glucocorticoid or estrogen deprivation therapy, chemotherapy-induced ovarian failure, and androgen deprivation therapy.

As people with cancer survive longer, cancer related bone disease and its treatment becomes an important health issue that needs to be addressed. For example, women undergoing therapy for breast cancer, without bone metastases, have been shown to have a fivefold higher prevalence of vertebral fractures than women without cancer of the same age. Men with prostatic cancer are at particularly high risk of osteoporosis and fracture due in part to treatment with androgen deprivation therapy. Rates of bone mineral density decrease can be as high as 3 to 5.6% within the first year of treatment alone.

Professor Ren Rizzoli, lead author and Professor
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Contact: L. Misteli
info@iofbonehealth.org
41-229-940-100
International Osteoporosis Foundation
Source:Eurekalert

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