Navigation Links
New Hope for Brain, Spinal Cord Injuries
Date:12/11/2009

Deletion of key gene could help nerve fibers regenerate, researchers say

FRIDAY, Dec. 11 (HealthDay News) -- Deleting a gene that suppresses natural growth factors enables regeneration of injured nerve fibers (axons) in mice, a new study shows.

The finding may lead to new treatments for people with brain and spinal cord injuries.

Researchers at Children's Hospital Boston deleted the gene SOCS3 -- an inhibitor of a growth pathway called mTOR -- in the retinal ganglion cells of mice. These cells are in the optic nerve, which carries signals from the eyes to the brain.

Removel of SOCS3 resulted in vigorous growth of injured axons. The greatest improvement was seen after one week, when the researchers also detected signs that the mTOR pathway was re-activated. Axon growth increased even more when the researchers applied a growth factor called ciliary neurotrophic factor (CNTF) directly to the eye of mice in which SOCS3 had been deleted. But CNTF only modestly boosted axon growth in mice that still had SOCS3.

"CNTF and other cytokines [cellular signaling molecules] have been tested for promoting axon regeneration previously, but with no success," study leader Zhigang He, of the F.M. Kirby Neurobiology Center at Children's Hospital Boston, said in a university news release. "Now we know that this is due to the tight negative control of SOCS3. Inhibiting SOCS3, using small molecule compounds or RNA interference, might allow these cytokine growth factors to be functional."

The study appears in the Dec. 10 issue of Neuron.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about spinal cord injury.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news rel
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Binge Drinking Puts the Brain, and Life Itself, at Risk
2. Surgery, Anesthesia & Your Brain, Not the Cache of Sex, Drugs, and Rock n Roll
3. Georgia State/Georgia Tech Center for Advanced Brain Imaging to expand brain, mind research
4. Sex is in the brain, says new research from Stanford
5. Liver Cirrhosis May Also Harm Brain, Heart
6. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
7. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
8. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
9. Fluorides Impact on Brain, A Focus of Two Conferences
10. Lou Gehrigs protein found throughout brain, suggesting effects beyond motor neurons
11. Fluoride May Damage the Brain, New Report Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... (PRWEB) September 01, 2014 Bioinformatics ... organize and analyze biological and genetic data. A ... activity of developing software tools to generate and ... be confused with biological computation. While bioinformatics simply ... of biology can its related concepts, biological computation ...
(Date:9/1/2014)... 2014 Top10BestSEOHosting.com has recently compared ... host suppliers carefully, Top10BestSEOHosting.com is here to announce ... web hosting suppliers in 2014. , JustHost ( ... a top-of-the-line shared hosting plan. The company’s approach ... that is affordable, accessible and powerful enough for ...
(Date:9/1/2014)... 01, 2014 AttorneyOne.com, a recognized authority ... latest information from the FDA on DePuy Synthes ... announced on August 28, that specific lots of DePuy ... I) as the device may reverse directions after surgery. ... (CMF) Distraction System is an implant used to lengthen ...
(Date:9/1/2014)... Mahwah, NJ (PRWEB) September 01, 2014 ... disorder (NEAD) is a psychological disorder that can have ... look very much like epileptic seizures however, they are ... rather by emotional triggers. It is estimated that ... than those affected by multiple sclerosis. , ...
(Date:8/31/2014)... 31, 2014 MedixSafe has become very ... and narcotics lockers . Electronic Security ... brand for distribution worldwide. “We have now shipped multiple ... McCollum, MedixSafe Sales Manager , MedixSafe is a division ... and network cabling company with over 30 years in ...
Breaking Medicine News(10 mins):Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 3Health News:The Northeast Regional Epilepsy Group (NEREG) Offers First Conference on Psychogenic Non-epileptic Seizures (PNES) on September 20, 2014 in New Jersey 2Health News:Memphis-based Electronic Security Specialists Now Offers MedixSafe Narcotics Cabinets Internationally 2Health News:Memphis-based Electronic Security Specialists Now Offers MedixSafe Narcotics Cabinets Internationally 3
... June 16 The famed nonprofit Los Angeles,Jewish Home ... program designed to address one of the major health ... Jewish Community Foundation,the largest manager of charitable assets for ... prevention and fitness program becomes part of the care,the ...
... 2008 Researchers at Ben-Gurion University of the Negev ... recognition system, tested at a Washington, D.C. hospital, that ... by motioning instead of touching a screen, keyboard or ... to a just released article. , The June article," ...
... from the Swedish medical university Karolinska Institute (KI) suggests that ... on if adults decide to have sex with persons of ... the individual,s unique experiences have the strongest influence on our ... in the world so far and was performed in collaboration ...
... injury-related deaths, the gap between black and white American ... at the Johns Hopkins Bloomberg School of Public Health. ... deaths among blacks ages 15 to 24 decreased, while ... in the June, 2008, edition of Injury Prevention ...
... partners, innovative use of Microsoft technology to exceed ... customer expectations and solve business problems., ... delivered exemplary solutions to customers, Microsoft Corp. today,announced ... Partner of the,Year Awards. The awards honor Microsoft ...
... PLM Based on Dassault Systemes, Newly,Introduced V6 Platform and Intercim,s ... ... PAUL, Minnesota, June 16 Intercim LLC, a global,leader in ... regulated industries and Dassault,Systemes (DS) (Nasdaq: DASTY; Euronext Paris: #13065, ...
Cached Medicine News:Health News:Los Angeles Jewish Home Institutes New Fall Prevention Program With Jewish Community Foundation Grant 2Health News:Los Angeles Jewish Home Institutes New Fall Prevention Program With Jewish Community Foundation Grant 3Health News:Gesture interface device developed by Ben-Gurion University of the Negev 2Health News:Racial disparities reduced in injury related mortality 2Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 2Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 3Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 4Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 5Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 6Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 7Health News:Intercim and Dassault Systemes Sign Memorandum of Understanding 2Health News:Intercim and Dassault Systemes Sign Memorandum of Understanding 3
(Date:8/29/2014)... 2014   Vittamed Corporation , a neurodiagnostics medical device ... that T. (Teo) Forcht Dagi , MD, DmedSc, MPH, ... Directors. " Teo Forcht Dagi is ... innovation and venture capital," said Remis Bistras , President ... his clinical, strategic, and entrepreneurial expertise to our Board." ...
(Date:8/29/2014)... -- Research and Markets has announced the ... 2014-2018" report to their offering. ... results in demyelination, axonal transection, and neurodegeneration. The myelin ... the immune system, which targets neurons within the central ... in which the damage of the myelin sheath causes ...
(Date:8/29/2014)... 29, 2014 Pixcelldata, the innovative ... has announced a major new deal with Dutch based ... pathology expert, Dr. Marius Nap . ... European Congress of Pathology which is taking placing between ... London where Pixcelldata will demonstrate ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2
AllMeds was the first specialty-specific Electronic Medical Record for Neurosurgery. Instead of trying to force a general-purpose EMR into your practice, AllMeds starts with clinical content from Neu...
... Optical dispensing is a part of about 40% ... have created a point of sale system. Optical ... program or it can be integrated to the ... national Frames database. Glasses prescriptions, if connected ...
... tasks such as prescription writing, referral letters, ... office will be ,able to add more ... increase staff., Based on the exam documentation ... will recommend the appropriate E&M ,code for ...
... Access your patients' electronic medical ... CardioChart. As a Web-enabled software ... pull up a patient's cardiology ... the hospital intranet. CardioChart displays ...
Medicine Products: