Navigation Links
New Hope for Brain, Spinal Cord Injuries
Date:12/11/2009

Deletion of key gene could help nerve fibers regenerate, researchers say

FRIDAY, Dec. 11 (HealthDay News) -- Deleting a gene that suppresses natural growth factors enables regeneration of injured nerve fibers (axons) in mice, a new study shows.

The finding may lead to new treatments for people with brain and spinal cord injuries.

Researchers at Children's Hospital Boston deleted the gene SOCS3 -- an inhibitor of a growth pathway called mTOR -- in the retinal ganglion cells of mice. These cells are in the optic nerve, which carries signals from the eyes to the brain.

Removel of SOCS3 resulted in vigorous growth of injured axons. The greatest improvement was seen after one week, when the researchers also detected signs that the mTOR pathway was re-activated. Axon growth increased even more when the researchers applied a growth factor called ciliary neurotrophic factor (CNTF) directly to the eye of mice in which SOCS3 had been deleted. But CNTF only modestly boosted axon growth in mice that still had SOCS3.

"CNTF and other cytokines [cellular signaling molecules] have been tested for promoting axon regeneration previously, but with no success," study leader Zhigang He, of the F.M. Kirby Neurobiology Center at Children's Hospital Boston, said in a university news release. "Now we know that this is due to the tight negative control of SOCS3. Inhibiting SOCS3, using small molecule compounds or RNA interference, might allow these cytokine growth factors to be functional."

The study appears in the Dec. 10 issue of Neuron.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about spinal cord injury.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Dec. 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Binge Drinking Puts the Brain, and Life Itself, at Risk
2. Surgery, Anesthesia & Your Brain, Not the Cache of Sex, Drugs, and Rock n Roll
3. Georgia State/Georgia Tech Center for Advanced Brain Imaging to expand brain, mind research
4. Sex is in the brain, says new research from Stanford
5. Liver Cirrhosis May Also Harm Brain, Heart
6. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
7. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
8. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
9. Fluorides Impact on Brain, A Focus of Two Conferences
10. Lou Gehrigs protein found throughout brain, suggesting effects beyond motor neurons
11. Fluoride May Damage the Brain, New Report Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... , ... Coast Dental Fort Stewart is celebrating its grand opening with an ... Furniture Mall at 112 Vilseck Road in Fort Stewart. There will be refreshments, giveaways, ... have the opportunity to meet general dentists Thomas Richards, DDS, and Josh Faulk, DMD, ...
(Date:4/29/2016)... ... April 29, 2016 , ... World Patent Marketing , ... exercise invention which aids in proper muscle development. , "The Gym & Exercise ... Director of World Patent Marketing. "Globalization has threatened the future growth of the ...
(Date:4/29/2016)... ... April 29, 2016 , ... Reltok Nasal Products proudly announces that Boston Medical ... neck/ear, nose and throat specialty, has added the KOTLER NASAL AIRWAY™ to its diverse ... is a newly patented safety device secured by nasal surgeons onto the floor of ...
(Date:4/29/2016)... N.J. (PRWEB) , ... April 29, 2016 , ... ... digital and print media enterprise focused entirely on patients with cancer, today announced ... California, was chosen as the 2016 CURE® Extraordinary Healer® for Oncology Nursing ...
(Date:4/29/2016)... ... April 29, 2016 , ... HEALTHCAREfirst , the ... services, and Deyta Analytics, recently announced the recipients of the fourth annual Hospice ... as measured from the caregiver’s point of view. The official list of recipients ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... le 27 Avril 2016 ... progressé de +5% sur le trimestre, soutenu par ... consommables  Croissance de +16% des ventes ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : ... laser, annonce aujourd,hui son chiffre d,affaires pour le ...
(Date:4/27/2016)... , April 27, 2016 ... titled, "Skincare Devices Market - Global Industry Analysis, Size, ... to the report, the global skincare devices market was ... anticipated to expand at a CAGR of 10.1% from ... 2023. Browse the full Skincare Devices Market (Treatment ...
(Date:4/27/2016)... , April 27, 2016  Bayer Animal Health ... senior from the University of Florida College of ... Bayer Excellence in Communication Award (BECA). Brittany was ... were awarded a total of $70,000 in scholarship ... four years, Bayer has provided a total of ...
Breaking Medicine Technology: