Navigation Links
New HPV Vaccine Promising in Mice
Date:4/15/2008

It might cover all types of HPV and be given as a nasal spray, researchers say

TUESDAY, April 15 (HealthDay News) -- Researchers say they've created a synthetic vaccine that can be delivered as a nasal spray for human papillomavirus -- the source of the most common sexually transmitted disease in the United States and a cause of cervical cancer.

The experimental vaccine, tested so far just with mice, also offers protection against different strains of HPV, the researchers said.

The existing vaccine for HPV, called Gardasil, protects against four strains of the virus that are responsible for about 70 percent of all cervical cancers. The Gardasil vaccine requires three injections for full protection.

"We have been trying to produce a single vaccine that would be able to protect patients against all cancer causing HPV types," said Richard B.S. Roden, lead researcher for the new study and an associate professor of pathology, gynecology and obstetrics, and oncology at Johns Hopkins University.

"What we have done is to try to develop a completely synthetic vaccine that would induce antibodies that would neutralize and protect against a whole range of these cancer-causing strains," he added.

The advantages of the synthetic vaccine are that it can be synthesized as if it were a drug, Roden said, adding that "it can be made chemically in the lab rather than having to use biological systems."

A synthetic vaccine also should be cheaper, Roden added. Using this approach, the vaccine could also be given nasally, he said.

"This may be another way to reduce the cost of vaccination, because you don't have to use needles," he said.

The findings are published in the April 15-18 issue of the Proceedings of the National Academy of Sciences.

In their experiments, Roden and his colleagues used a protein from one of the strains of HPV -- HPV16 -- to create a man-made vaccine in the laboratory. When the vaccine was given to mice either by injection or nasal spray, it protected not only against HPV16, but also against another strain of the virus -- HPV45.

Roden said the mice used in this experiments had special immune system T helper cells for the vaccine to attach itself. Whether human T helper cells would work in all groups of people isn't known, he said. "Right now, that's an area we are looking at," he said.

HPV is responsible for genital warts and about 99.7 percent of all cervical cancers worldwide.

Debbie Saslow, director of breast and gynecologic cancer at the American Cancer Society, said that if this vaccine could be developed, it would represent an important advance in getting more people vaccinated against HPV, especially in developing countries.

"While we have wonderful opportunities with the current vaccine, there are limitations," she said.

One limitation is the cost of the Gardasil vaccine, an estimated $300 to $500, Saslow added. "That's a limitation in this country, but particularly in the developing world where there is so much cervical cancer," she said.

The Gardasil vaccine also requires three shots, which is difficult in developing countries and among adolescents, Saslow said.

"Needle-less vaccination is the way to go for a lot of reasons," she said. "The current shots are extremely painful, and that's going to be a deterrent for teenage populations, as is going back and getting the three doses."

More information

To learn more about HPV, visit the U.S. Centers for Disease Control and Prevention.



SOURCES: Richard B.S. Roden, Ph.D., associate professor of pathology, gynecology and obstetrics, and oncology, Johns Hopkins University, Baltimore; Debbie Saslow, Ph.D., director, breast and gynecologic cancer, American Cancer Society, Atlanta; April 15-18, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Breast Cancer Vaccine Works Against Deadlier Form of Disease
2. Boston Trial to Test New HIV/AIDS Vaccine
3. Researchers Pursuing Nasal Anthrax Vaccine
4. Adults Need Protection Against Vaccine-Preventable Diseases, Too
5. Iomai Wins Department of Defense Grant to Develop a Stable, Patch-Based Anthrax Vaccine
6. Actress/Producer Salma Hayek Launches The Pampers(R) One Pack = One Vaccine Program to Benefit UNICEF
7. Gardasil, Other New Products Spur Strong Vaccine Sales in 2007
8. Alzheimers vaccine clears plaque but has little effect on learning and memory impairment
9. FDA OKs New Rotavirus Vaccine
10. Vaccine Induced Inflammation Linked to Epidemic of Type 2 Diabetes and Metabolic Syndrome
11. FDA APPROVES ROTARIX(R) [Rotavirus Vaccine, live, oral], THE FIRST VACCINE LICENSED TO COMPLETE THE ROTAVIRUS IMMUNIZATION SERIES BY FOUR MONTHS OF AGE
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... MedPro Waste Disposal, LLC (MedPro) is proud ... now offers its mail back service for an all-inclusive rate. MedPro Disposal President, Dan ... provide service to all of the clients in the country who are looking for ...
(Date:5/2/2016)... ... ... Further establishing itself as a leader in natural pet products category, Paragon ... selected from over 1,000 entrants as a winner and recipient of the prestigious GLOBAL ... dogs are a favorite product among pet-parents worldwide, as each whimsical knobby shape of ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Rassouli, dentist in ... cognitive decline. According to the research, which was published in the “Journal of the ... decline, and about 5.4 million Americans have Alzheimer’s disease. The study found that dental ...
(Date:5/2/2016)... ... ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed roster was announced in February and ... WUGC is being held in London, England this year from June 18-25. At the last ... gold in the women’s masters division, and a silver in the women’s division, so Mazur ...
(Date:5/2/2016)... , ... May 02, 2016 , ... According to an ... one in four girls are sexually abused before the age of 18. Of those ... to tell her story and others. , In her new book, Lyah! Lyah! ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... ALBANY, New York , April 27, 2016 /PRNewswire/ ... new market report titled, "Skincare Devices Market - Global ... - 2023." According to the report, the global skincare ... 2014 and is anticipated to expand at a CAGR ... 17,299.4 Mn in 2023. Browse the full Skincare ...
(Date:4/27/2016)... , April 27, 2016  Bayer Animal ... a senior from the University of Florida College ... the Bayer Excellence in Communication Award (BECA). Brittany ... which were awarded a total of $70,000 in ... last four years, Bayer has provided a total ...
(Date:4/27/2016)... 2016 Oasmia Pharmaceutical AB ... a new generation of drugs within human and ... for Paclical/Apealea in the Phase III study that ... ovarian cancer. These preliminary results showed non-inferiority between ... carboplatin versus Taxol in combination with carboplatin. In ...
Breaking Medicine Technology: