Navigation Links
New Guidelines Issued for Genetic Screening in Newborns, Children
Date:2/21/2013

By Denise Mann
HealthDay Reporter

THURSDAY, Feb. 21 (HealthDay News) -- New guidelines on testing newborns and children for genetic diseases recommend screening for childhood diseases but note that testing for diseases that strike in adulthood may not be worthwhile.

About 4 million infants in the United States undergo newborn screening each year, but further genetic testing -- while increasingly available -- is less common. Newborn screening panels vary from state to state.

All newborns should be tested for the genetic diseases that are included in their state's newborn screening panel, but anything beyond that is up to parents and the decision must be made in the child's best interest, according to the revised policy statement from the American Academy of Pediatrics and the American College of Medical Genetics and Genomics. The new guidelines are published online Feb. 21 in the journal Pediatrics.

The recommendations distinguish between genetic testing for childhood-onset conditions versus those for adult-onset conditions. For kids who may be at risk for a childhood disease, testing is worth considering, the guidelines state, but the same does not hold true if the child is thought to be at risk for a disease that strikes in adulthood.

"There is an important role for counseling before and after genetic screening," added policy author Dr. Lainie Friedman Ross, a pediatrician and ethicist at the University of Chicago. "The focus should be on education of families, counseling them and helping them make decisions that focus on the child's best interest."

The new guidelines do not call for any specific genetic tests; instead they recommend mandatory offering of state newborn screening panels. "We believe that if parents are informed that the benefits outweigh the risks, that they will give their permission, given that all states screen for at least the uniform panel and it is included in costs of birth hospitalization," Friedman Ross said.

Testing for disease in the presence of symptoms is another area addressed by the new recommendations. "Clearly, if a child has symptoms, we need a diagnosis to help the family make clinical decisions that are in the child's best interest. This is important even when the disease has no current therapies," Friedman Ross added.

Kids should also be informed of the results when they reach an appropriate age, she added.

The guideline authors caution against using direct-to-consumer genetic screening tests, because there is no oversight and the results are open to interpretation.

Pediatricians and geneticists said they are on board with the new recommendations.

"In newborns, we look for things that are treatable and have interventions that will have a significant impact on the child," said Dr. Marshall Summar, division chief of genetics and metabolism at Children's National Medical Center in Washington, D.C.

But "it's a moving target," he said. "We have to constantly reassess this as the technology and our understanding of what the results mean changes."

There are risks when it comes to broad-based gene screens outside of traditional newborn screening panels, said Dr. Parul Jayakar, a clinical and metabolic geneticist at Miami Children's Hospital. "We may find things that never come to fruition or results that we can't fully interpret yet," he explained.

However, there are also cases were being forewarned is being forearmed, said Dr. Joyce Fox, a medical genetics doctor at North Shore University Hospital in Manhasset, N.Y.

If there is a family history of a genetic disease, even adult-onset ones, there are some instances where knowing this early will make a difference. This includes certain cancers, including a rare type of inherited colon cancer. "We would want the information earlier so we can do appropriate surveillance on the children and prevent the onset of significant disease," Fox said.

But it should be buyer beware when it comes to direct-to-consumer gene screens, she said.

"We highly discourage these even on adults, and particularly on children, because there is nobody there to provide counseling and interpretation," Fox said. These can also be very costly, and are likely not covered by insurance."

More information

Learn more about newborn screening at the U.S. National Institutes of Health.

SOURCES: Lainie Friedman Ross, M.D., Ph.D., pediatrician, University of Chicago; Parul Jayakar, M.D., M.S., clinical and metabolic geneticist, Miami Children's Hospital; Marshall Summar, M.D., division chief, genetics and metabolism, Children's National Medical Center, Washington, D.C.; Joyce Fox, M.D., medical geneticist, North Shore University Hospital, Manhasset, N.Y.; Feb. 21, 2013, Pediatrics, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. “We Are Not Worried”, Says Shopping Cart Provider, Shopping Cart Elite in Response to Latest Google Webmaster Guidelines
2. Re-Analysis Refutes Diet Guidelines Favoring Vegetable Fats
3. LTC Guild Member Releases Guidelines for Securing Long-Term Care Insurance for Parents
4. HMHP and St. E’s Earns American Heart Association’s ‘Get With the Guidelines’ Gold Plus Award
5. New Stroke Guidelines Stress Treatment Within One Hour of Arrival in ER
6. First-Ever Guidelines Issued for Treating Type 2 Diabetes in Kids
7. First guidelines for brain amyloid imaging in Alzheimers released
8. ISHLT issues new guidelines for care of mechanical circulatory support device patients
9. Younger Women Start to Follow Pap Test Guidelines: CDC
10. New Diabetes Guidelines May Lower Patient Medical Bills
11. New Guidelines Seek to Streamline Care for Worst Heart Attacks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Guidelines Issued for Genetic Screening in Newborns, Children
(Date:2/8/2016)... ... February 08, 2016 , ... Brenntag Specialties, Inc.(BSI) , ... Food & Beverage and Dietary Supplement market segments across the ... USA geographies east of the Rocky Mountains since 2012. Consistent performance in ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... LA, celebrates the beginning of a new charity campaign. As part of their ... Special Advocates (CASA). In the belief that children deserve a voice, and in ...
(Date:2/8/2016)... ... 2016 , ... A man who has struggled to quit smoking, a man who has struggled ... to find solutions to his problems – and he did. Now Nabat, a serial entrepreneur ... introduce his breakthrough inventions to the world and better people's lives. His own experience with ...
(Date:2/8/2016)... ... ... If you are feeling that your clothes are a tad snug, the ... Center for Disease Control and Prevention (CDC), 34.9% of U.S. adult women are overweight. ... some of the leading causes of preventable death. February is heart health month ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Syneron Medical Ltd. ... device company, announced today that William Griffing ... America, is scheduled to participate in the Leerink ... on February 11, 2016 in New ... institutional investors to meet with the Mr. Griffing ...
(Date:2/5/2016)... 5, 2016 ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ...
(Date:2/5/2016)... , Feb. 5, 2016  Zimmer Biomet Holdings, ... of the previously announced underwritten secondary offering of 11,027,558 ... stockholders, consisting of affiliates of Blackstone and Goldman Sachs. ... an initial price of $96.45 per share. The selling ... offering.  Neither Zimmer Biomet nor any of its directors, ...
Breaking Medicine Technology: