Navigation Links
New Guidelines Issued for Genetic Screening in Newborns, Children
Date:2/21/2013

By Denise Mann
HealthDay Reporter

THURSDAY, Feb. 21 (HealthDay News) -- New guidelines on testing newborns and children for genetic diseases recommend screening for childhood diseases but note that testing for diseases that strike in adulthood may not be worthwhile.

About 4 million infants in the United States undergo newborn screening each year, but further genetic testing -- while increasingly available -- is less common. Newborn screening panels vary from state to state.

All newborns should be tested for the genetic diseases that are included in their state's newborn screening panel, but anything beyond that is up to parents and the decision must be made in the child's best interest, according to the revised policy statement from the American Academy of Pediatrics and the American College of Medical Genetics and Genomics. The new guidelines are published online Feb. 21 in the journal Pediatrics.

The recommendations distinguish between genetic testing for childhood-onset conditions versus those for adult-onset conditions. For kids who may be at risk for a childhood disease, testing is worth considering, the guidelines state, but the same does not hold true if the child is thought to be at risk for a disease that strikes in adulthood.

"There is an important role for counseling before and after genetic screening," added policy author Dr. Lainie Friedman Ross, a pediatrician and ethicist at the University of Chicago. "The focus should be on education of families, counseling them and helping them make decisions that focus on the child's best interest."

The new guidelines do not call for any specific genetic tests; instead they recommend mandatory offering of state newborn screening panels. "We believe that if parents are informed that the benefits outweigh the risks, that they will give their permission, given that all states screen for at least the uniform panel and it is included in costs of birth hospitalization," Friedman Ross said.

Testing for disease in the presence of symptoms is another area addressed by the new recommendations. "Clearly, if a child has symptoms, we need a diagnosis to help the family make clinical decisions that are in the child's best interest. This is important even when the disease has no current therapies," Friedman Ross added.

Kids should also be informed of the results when they reach an appropriate age, she added.

The guideline authors caution against using direct-to-consumer genetic screening tests, because there is no oversight and the results are open to interpretation.

Pediatricians and geneticists said they are on board with the new recommendations.

"In newborns, we look for things that are treatable and have interventions that will have a significant impact on the child," said Dr. Marshall Summar, division chief of genetics and metabolism at Children's National Medical Center in Washington, D.C.

But "it's a moving target," he said. "We have to constantly reassess this as the technology and our understanding of what the results mean changes."

There are risks when it comes to broad-based gene screens outside of traditional newborn screening panels, said Dr. Parul Jayakar, a clinical and metabolic geneticist at Miami Children's Hospital. "We may find things that never come to fruition or results that we can't fully interpret yet," he explained.

However, there are also cases were being forewarned is being forearmed, said Dr. Joyce Fox, a medical genetics doctor at North Shore University Hospital in Manhasset, N.Y.

If there is a family history of a genetic disease, even adult-onset ones, there are some instances where knowing this early will make a difference. This includes certain cancers, including a rare type of inherited colon cancer. "We would want the information earlier so we can do appropriate surveillance on the children and prevent the onset of significant disease," Fox said.

But it should be buyer beware when it comes to direct-to-consumer gene screens, she said.

"We highly discourage these even on adults, and particularly on children, because there is nobody there to provide counseling and interpretation," Fox said. These can also be very costly, and are likely not covered by insurance."

More information

Learn more about newborn screening at the U.S. National Institutes of Health.

SOURCES: Lainie Friedman Ross, M.D., Ph.D., pediatrician, University of Chicago; Parul Jayakar, M.D., M.S., clinical and metabolic geneticist, Miami Children's Hospital; Marshall Summar, M.D., division chief, genetics and metabolism, Children's National Medical Center, Washington, D.C.; Joyce Fox, M.D., medical geneticist, North Shore University Hospital, Manhasset, N.Y.; Feb. 21, 2013, Pediatrics, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. “We Are Not Worried”, Says Shopping Cart Provider, Shopping Cart Elite in Response to Latest Google Webmaster Guidelines
2. Re-Analysis Refutes Diet Guidelines Favoring Vegetable Fats
3. LTC Guild Member Releases Guidelines for Securing Long-Term Care Insurance for Parents
4. HMHP and St. E’s Earns American Heart Association’s ‘Get With the Guidelines’ Gold Plus Award
5. New Stroke Guidelines Stress Treatment Within One Hour of Arrival in ER
6. First-Ever Guidelines Issued for Treating Type 2 Diabetes in Kids
7. First guidelines for brain amyloid imaging in Alzheimers released
8. ISHLT issues new guidelines for care of mechanical circulatory support device patients
9. Younger Women Start to Follow Pap Test Guidelines: CDC
10. New Diabetes Guidelines May Lower Patient Medical Bills
11. New Guidelines Seek to Streamline Care for Worst Heart Attacks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Guidelines Issued for Genetic Screening in Newborns, Children
(Date:6/27/2016)... California (PRWEB) , ... June ... ... pioneer in the patient payment industry today announced its strategic partnership with ... health system workflows. , The two companies’ proven, proprietary technology combine to ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: