Navigation Links
New Genetic Clues to Breast Cancer?
Date:1/23/2012

By Kathleen Doheny
HealthDay Reporter

SUNDAY, Jan. 22 (HealthDay News) -- Researchers have identified three new genomic regions they believe are linked with breast cancer that may help explain why some women develop the disease.

All three newly identified areas "contain interesting genes that open up new avenues for biological and clinical research," said researcher Douglas Easton, a professor of genetic epidemiology at the University of Cambridge in England.

Breast cancer is the most common cancer among women, with about 1 million new cases annually worldwide and more than 400,000 deaths a year.

Scientists conducting genome-wide association studies -- research that looks at the association between genetic factors and disease to pinpoint possible causes -- had already identified 22 breast cancer susceptibility loci. Locus is the physical location of a gene or DNA sequence on a chromosome.

"The three [newly identified] loci take the number of common susceptibility loci from 22 to 25," said Easton.

However, the three new susceptibility loci might explain only about 0.7 percent of the familial risks of breast cancer, bringing the total contribution to about 9 percent, the researchers said.

Michael Melner, scientific program director for the American Cancer Society, said this current research adds some important new clues to existing evidence, but he agreed that the number of cases likely associated with these three variants is probably low.

"So the total impact in terms of patients would be fairly small," Melner said.

The study is published online Jan. 22 in Nature Genetics.

To find the new clues, Easton's team worked with genetic information on about 57,000 breast cancer patients and 58,000 healthy women obtained from two genome-wide association studies.

The investigators zeroed in on 72 different single nucleotide polymorphisms (SNPs). A SNP -- pronounced "snip" -- is a change in which a single base in the DNA differs from the usual base. The human genome has millions of SNPs, some linked with disease, while others are normal variations.

The researchers focused on three SNPs -- on chromosomes 12p11, 12q24 and 21q21.

Easton's team found that the variant on the 12p11 chromosome is linked with both estrogen receptor-positive breast cancer (which needs estrogen to grow) and estrogen receptor-negative breast cancer. The other two variants are only linked with ER-positive cancers, they said.

One of the newly identified variants is in an area with a gene that has a role in the development of mammary glands and bones. Easton said it was already known that mammary gland development in puberty is an important period in terms of determining later cancer risk. "But these are the first susceptibility genes to be shown to be involved in this process," he said.

One of the other SNPs is in an area that can affect estrogen receptor signaling, the researchers found.

Melner, noting some of the research is "fine tuning" of other work, said in his view the new understanding of the signaling pathways and their genetic links is the most important finding.

"When you delineate a pathway, you bring up new potential targets for therapy," he said. "The more targets you have, you open up the potential for having multiple drugs and attacking a cancer more easily, without it becoming more resistant."

Overall, Melner added, the results underscore the complexity of the different mechanisms involved in breast cancer development.

More information

For more about the genetics of breast cancer, visit the American Cancer Society.

SOURCES: Douglas Easton, Ph.D., professor, genetic epidemiology, University of Cambridge, England; Michael H. Melner, Ph.D., scientific program director, American Cancer Society; Jan. 22, 2012, Nature Genetics, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Genetic Clues to Breast Cancer?
(Date:2/20/2017)... (PRWEB) , ... February 21, 2017 , ... Nancy ... offering readers a way to “ Getting Over the Bump in the Road ” ... and lessons learned on how to cope with the ups and downs experienced by ...
(Date:2/20/2017)... ... February 20, 2017 , ... Silverado today is pleased ... open and operate a state-of-the-art memory care community in Alexandria, Virginia. The new community ... site just outside of Old Town. , The three-story community with underground parking ...
(Date:2/20/2017)... FL (PRWEB) , ... February 20, 2017 , ... ... beth[at]orbitahealth[dot]com, +1 (414) 213-8818 , Orbita, Inc., a leading provider of innovative software ... solution for increasing patient engagement and optimizing care journey management for home healthcare. ...
(Date:2/20/2017)... ... , ... Clearwave is the leading provider in ... XT-series of touch screen terminals. Both companies will be showcasing their solutions at ... provider Posiflex is helping to bridge the gap between healthcare hardware and software ...
(Date:2/20/2017)... ... February 20, 2017 , ... Today, ... Document Router (BDR), the first IoT device from Biscom designed to deliver confidential ... will debut BDR at HIMSS17 and will be conducting demonstrations at ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , Feb. 20, 2017   MedPlast, Inc. ... device industry, announced today that it has signed ... Device Manufacturing Services business.   The acquisition broadens ... as a leading services provider to the world,s ... will further expand the company,s capabilities in assembly ...
(Date:2/20/2017)... Provides understanding and access to the ... by the worlds leading healthcare companies. Download ... The Global Renal Failure Partnering Terms and Agreements ... partnering deals and agreements entered into by the ... in partnering deals - Top deals by ...
(Date:2/20/2017)... NEW YORK , Feb. 20, 2017 ... imaging technique that creates detailed images of the organs ... a magnetic field and radio waves. The technique does ... the study of brain function or growth of cancer. ... such as neurology, cardiology, oncology, musculoskeletal, and orthopedics. Hence, ...
Breaking Medicine Technology: