Navigation Links
New Gene Linked to Congenital Heart Defects
Date:5/4/2011

WEDNESDAY, May 4 (HealthDay News) -- A gene essential to cardiac development has been associated with a group of congenital heart defects that cause a major proportion of childhood death from heart abnormalities.

It is unclear how these cardiac defects -- all malformations of the left ventricular outflow tract (LVOT) -- develop. The new research suggests a genetic component may play a role.

"It is estimated that there are more than 500 genes that may be important in heart development," said lead investigator Dr. Kim McBride, from the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital and a faculty member at The Ohio State University College of Medicine. "Changes in any of these genes may impact how a child's heart forms."

Researchers at the Nationwide Children's Hospital set out to identify specific genes involved in cardiac development by examining the DNA of children treated for left ventricular outflow tract malformations and their parents. The study revealed a new link between the gene ERBB4 and specific LVOT defects.

Researchers said ERBB4 encodes a protein that serves as an "on" or "off" switch in many cellular functions during heart development.

"The precise defect in this very large gene is not yet known," said McBride. "ERBB4 now joins a previously identified gene, NOTCH1, as a susceptibility gene for LVOT defects. Replication of these results in other subjects will be required to better determine its role in the development of the heart malformations."

The LVOT defects include a narrowing of the aorta, a large blood vessel that branches off the heart, which causes it to pump abnormally hard (coarctation of the aorta) and a narrowing of the heart's aortic valve that obstructs normal blood flow (aortic valve stenosis).

They also include a rare heart defect in which the left side of the heart is severely underdeveloped (hypoplastic left
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Cotton Swabs Linked to Ruptured Eardrums, Study Shows
2. Insomnia linked to high insulin resistance in diabetics
3. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
4. Medical sleuthing linked muscle, kidney problems to kava tea
5. Being Housebound Linked to Alzheimers in Elderly
6. Mental Disorders Linked to Drug, Alcohol Abuse in U.S. Vets
7. Newer Pill Linked to Higher Risk of Blood Clots
8. Student Bullying Linked to Family Violence: CDC
9. Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids
10. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
11. Gene Variant May Be Linked to Deadly Lung Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Gene Linked to Congenital Heart Defects  
(Date:4/26/2015)... 2015 In an article published last ... the head-neck biomechanics occurring during the use of handheld electronic ... to determine that use of a tablet increases mechanical demand ... times - more than when the neck is in a ... study, but pointing out the potential hazards of overuse of ...
(Date:4/26/2015)... 26, 2015 MidSouth Pain Treatment ... the Southeast. MidSouth Pain Treatment Center is a comprehensive ... Southaven, Oxford and Jackson, two ambulatory surgery centers in ... Southaven and Cordova locations. , Dr. Michael Steuer ... into medicine to help people, and when I discovered ...
(Date:4/25/2015)... California (PRWEB) April 26, 2015 Avid ... search for original 1965 Rolling Stones Greensboro Coliseum concert posters. ... was part of the Stone's Second American Tour. ... Globe Poster Company out of Baltimore, Maryland. This poster ... the northeast and southern cites. Globe uses garish lettering ...
(Date:4/25/2015)... In the United States alone, an estimated 23.5 ... an illicit drug or alcohol problem in ... Services Administration’s Survey on Drug Use and Health (published ... stories of men and women whose lives have been ... Kerr , founder and retired president of the nationally ...
(Date:4/25/2015)... April 25, 2015 By definition, a CIO’s ... for the enterprise relying on their judgement and expertise to ... But according to an article published in National Mortgage ... actually be doing a disservice to their responsibilities by focusing ... and t’s are crossed when it comes to company policy ...
Breaking Medicine News(10 mins):Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:Growing Pains for MidSouth Pain Treatment Center 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5
... For the ninth consecutive year,hundreds of Conseco employees ... for the needy of central Indiana as part of ... Each holiday season, Conseco partners with the United ... in need. Conseco provides up,to $1,000 of funding per ...
... two of the most innovative new voices in the pro-life ... Jan. 21-23. , , ... The TAW will feature Jill Stanek, renowned pro-life blogger ... during the 2008 presidential elections, and Lila Rose, the ...
... de C.V. (BMV: LAB) ("Genomma Lab" or "the Company"), ... company,announced today its 2009 earnings guidance. The Company ... range of 21% - 22% in,net sales and an ... These estimates,are based on the organic growth of ...
... exercise may be to blame, experts say , , WEDNESDAY, Dec. 10 ... are overweight or obese face twice the risk of injury to ... study reveals. , The findings come from a national sample of ... , "Ultimately, motor vehicle crashes are the leading cause of death ...
... Goes Multi-Platform , , Company Appoints ... , , NEW YORK, Dec. 10 ... with Hay House, the world,s leading publisher of self-improvement books and ... Losing Weight, Getting Fit, and Transforming Your Life. The ...
... MOUNTAIN VIEW, Calif., Dec. 10 The Chemicals, Materials ... announce its 2008 Quarterly,Analyst Briefing Presentation on the omega-3 ... at 8:00 a.m. PST. , ... Estimates show Cardiovascular Disease (CVD) ...
Cached Medicine News:Health News:Conseco Employees Provide Holiday Cheer for 40 Central Indiana Families 2Health News:A.L.L. Personhood Conference Features Pro-Life New Media Stars 2Health News:Genomma Lab Announces 2009 Earnings Guidance 2Health News:Obese Kids More Prone to Limb Injuries in Car Crashes 2Health News:Obese Kids More Prone to Limb Injuries in Car Crashes 3Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 2Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 3Health News:Fishing for Opportunities in the Omega-3 Ingredients Market 2
(Date:4/24/2015)...  Elekta has CE marked the latest version (v5.10) ... enabling European clinics to deliver a sophisticated radiation therapy ... 3D planning, IMRT, VMAT and stereotactic planning – all ... Monaco ® v5.10 provides significant planning ... in 3D planning as well as the addition of ...
(Date:4/23/2015)... April 23, 2015  ResMed Inc. (NYSE: RMD ... 31, 2015.  Revenue for the quarter was $422.5 million, ... March 31, 2014 (a 13 percent increase on a ... increase of 1 percent compared to the quarter ended ... quarter were $0.64, an increase of 2 percent compared ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
Breaking Medicine Technology:Elekta CE marks for Monaco v5.10 treatment planning system 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 11ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 12ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 13Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2
... 5, 2011 Express Scripts contributed more than $226 ... economic analysis of the company,s data by a university ... The economic impact study, presented today to state economic ... support 2,665 direct and indirect jobs in the state. ...
... NeuroVasx announced today that the FDA ... Humanitarian Use Device (HDE) for the treatment of large, ... most difficult to treat.  The HDE allows for the ... the U.S. (Logo: http://photos.prnewswire.com/prnh/20110405/CG77724LOGO ) ...
Cached Medicine Technology:Express Scripts Injects $226 Million Into Arizona Economy, Study Finds 2NeuroVasx Receives FDA Approval for cPAX Aneurysm Treatment System 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: