Navigation Links
New Gene Linked to Congenital Heart Defects

WEDNESDAY, May 4 (HealthDay News) -- A gene essential to cardiac development has been associated with a group of congenital heart defects that cause a major proportion of childhood death from heart abnormalities.

It is unclear how these cardiac defects -- all malformations of the left ventricular outflow tract (LVOT) -- develop. The new research suggests a genetic component may play a role.

"It is estimated that there are more than 500 genes that may be important in heart development," said lead investigator Dr. Kim McBride, from the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital and a faculty member at The Ohio State University College of Medicine. "Changes in any of these genes may impact how a child's heart forms."

Researchers at the Nationwide Children's Hospital set out to identify specific genes involved in cardiac development by examining the DNA of children treated for left ventricular outflow tract malformations and their parents. The study revealed a new link between the gene ERBB4 and specific LVOT defects.

Researchers said ERBB4 encodes a protein that serves as an "on" or "off" switch in many cellular functions during heart development.

"The precise defect in this very large gene is not yet known," said McBride. "ERBB4 now joins a previously identified gene, NOTCH1, as a susceptibility gene for LVOT defects. Replication of these results in other subjects will be required to better determine its role in the development of the heart malformations."

The LVOT defects include a narrowing of the aorta, a large blood vessel that branches off the heart, which causes it to pump abnormally hard (coarctation of the aorta) and a narrowing of the heart's aortic valve that obstructs normal blood flow (aortic valve stenosis).

They also include a rare heart defect in which the left side of the heart is severely underdeveloped (hypoplastic left heart syndrome), a set of four heart defects that cause inflow and outflow problems (Shone complex) and a very rare heart defect in which the aorta is not fully developed (interrupted aortic arch type).

The study appears in the journal Birth Defects Research Part A.

More information

The U.S. National Heart, Lung, and Blood Institute lists detailed information on congenital heart defects .

-- Mary Beth Dallas

SOURCE: Nationwide Children's Hospital, news release, April 29, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cotton Swabs Linked to Ruptured Eardrums, Study Shows
2. Insomnia linked to high insulin resistance in diabetics
3. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
4. Medical sleuthing linked muscle, kidney problems to kava tea
5. Being Housebound Linked to Alzheimers in Elderly
6. Mental Disorders Linked to Drug, Alcohol Abuse in U.S. Vets
7. Newer Pill Linked to Higher Risk of Blood Clots
8. Student Bullying Linked to Family Violence: CDC
9. Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids
10. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
11. Gene Variant May Be Linked to Deadly Lung Fibrosis
Post Your Comments:
Related Image:
New Gene Linked to Congenital Heart Defects  
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid ... America. As people age, more care is needed, especially with Alzheimer’s, dementia and ... professionals are being overworked. The forgotten part of this equation: 80 percent of ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When I was traveling, I ... Hillside, N.J. "Many people catch diseases simply from sitting on such dirty toilet ... protected from germs." , He developed the patent-pending QUDRATECS to eliminate the need ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a set ... With ProSidebar: Fasion, video editors can easily add an informative sidebar to any ... opener. Utilize presets featuring self-animating drop zones, lines, bars, and text with the ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official group for end ... Microsoft Dynamics SL software users, partners, industry experts and representatives. Intellitec Solutions’ membership ...
(Date:11/27/2015)... Karnataka (PRWEB) , ... November 27, 2015 , ... ... world, Health-E-minds, an innovative online platform for mental health and wellness consultation, has ... , This partnership will bridge the knowledge gap experienced by parents and bring ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... UTRECHT , Niederlande, November 27, 2015 /PRNewswire/ ... mit fotodynamischer Bremachlorin-Therapie bei fortgeschrittenem Krebs.   ... fotodynamischer Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... fotodynamischer Bremachlorin-Therapie bei fortgeschrittenem Krebs.   ... berichtet. --> Clinical Cancer Research ...
(Date:11/26/2015)... Países Bajos, November 26, 2015 ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... con la terapia fotodinámica de Bremachlorin para el cáncer ... enfoque combina la inmunoterapia con la terapia fotodinámica de ... Clinical Cancer Research . --> Clinical Cancer ...
(Date:11/26/2015)... -- Research and Markets ( ) has announced the ... to 2019 - Rise in Cardiac Disorders and Growing Awareness ... their offering. Boston scientific ... scientific and others. --> The market is ... Boston scientific and others. ...
Breaking Medicine Technology: