Navigation Links
New Gene Linked to Congenital Heart Defects
Date:5/4/2011

WEDNESDAY, May 4 (HealthDay News) -- A gene essential to cardiac development has been associated with a group of congenital heart defects that cause a major proportion of childhood death from heart abnormalities.

It is unclear how these cardiac defects -- all malformations of the left ventricular outflow tract (LVOT) -- develop. The new research suggests a genetic component may play a role.

"It is estimated that there are more than 500 genes that may be important in heart development," said lead investigator Dr. Kim McBride, from the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital and a faculty member at The Ohio State University College of Medicine. "Changes in any of these genes may impact how a child's heart forms."

Researchers at the Nationwide Children's Hospital set out to identify specific genes involved in cardiac development by examining the DNA of children treated for left ventricular outflow tract malformations and their parents. The study revealed a new link between the gene ERBB4 and specific LVOT defects.

Researchers said ERBB4 encodes a protein that serves as an "on" or "off" switch in many cellular functions during heart development.

"The precise defect in this very large gene is not yet known," said McBride. "ERBB4 now joins a previously identified gene, NOTCH1, as a susceptibility gene for LVOT defects. Replication of these results in other subjects will be required to better determine its role in the development of the heart malformations."

The LVOT defects include a narrowing of the aorta, a large blood vessel that branches off the heart, which causes it to pump abnormally hard (coarctation of the aorta) and a narrowing of the heart's aortic valve that obstructs normal blood flow (aortic valve stenosis).

They also include a rare heart defect in which the left side of the heart is severely underdeveloped (hypoplastic left heart syndrome), a set of four heart defects that cause inflow and outflow problems (Shone complex) and a very rare heart defect in which the aorta is not fully developed (interrupted aortic arch type).

The study appears in the journal Birth Defects Research Part A.

More information

The U.S. National Heart, Lung, and Blood Institute lists detailed information on congenital heart defects .

-- Mary Beth Dallas

SOURCE: Nationwide Children's Hospital, news release, April 29, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cotton Swabs Linked to Ruptured Eardrums, Study Shows
2. Insomnia linked to high insulin resistance in diabetics
3. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
4. Medical sleuthing linked muscle, kidney problems to kava tea
5. Being Housebound Linked to Alzheimers in Elderly
6. Mental Disorders Linked to Drug, Alcohol Abuse in U.S. Vets
7. Newer Pill Linked to Higher Risk of Blood Clots
8. Student Bullying Linked to Family Violence: CDC
9. Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids
10. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
11. Gene Variant May Be Linked to Deadly Lung Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Gene Linked to Congenital Heart Defects  
(Date:2/24/2017)... ... 24, 2017 , ... Healthcare Associates of McKinney announced today that ... at 8080 State Highway 121, Suite 210, McKinney, Texas 75070. It is in ... , As the practice has grown, the need for more space has been paramount. ...
(Date:2/24/2017)... ... February 24, 2017 , ... The International Association of Eating Disorders Professionals ... What You See” body image mannequin art competition. Selected from 15 submissions from around ... winner revealed at the 31st annual iaedp Symposium, March 22 – 26 in Las ...
(Date:2/24/2017)... ... 24, 2017 , ... Castle Farms, the celebrated Northern ... with the winning couple announced on Feb. 14, 2017, on Facebook. The free ... vendors: A Matter of Taste, Ryan Rousseau Enterprises, A Touch of Spring and ...
(Date:2/23/2017)... ... 2017 , ... Rare Disease Report®, which is the only ... Disease Day events, hosted by the Rare Disease Legislative Advocates (RDLA) on February ... e-newsletter and quarterly publication, will be conducting interviews with patients and advocates in ...
(Date:2/23/2017)... ... February 23, 2017 , ... EBSCO Information Services ... Institute for Health and Care Excellence (NICE) framework. The agreement allows purchasers ... (NHS) to search, order and purchase medical and healthcare-related content through GOBI ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... NEW YORK , Feb. 24, 2017 ... Monteverde & Associates PC , a boutique securities ... New York City , announces that a ... of Massachusetts  against Inotek Pharmaceuticals ... purchasers of the Company,s securities between July 23, 2015 and ...
(Date:2/24/2017)... Australien, 24. Februar 2017 ITL Limited, ... des Gesundheitsbereiches, ist erfreut, für das zum 31. ... entsprechenden Vorjahreszeitraum exzellente Ergebnisse vorlegen zu können. Eine ... zum Wachstum" finden Sie hier . ... nach Steuern 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
(Date:2/24/2017)... 2017  This report analyzes the worldwide markets for ... Products: Intermediates, Analytical, and Others. The End ... and Agrochemicals. The report provides separate comprehensive analytics for ... Europe , and Rest of World. Annual estimates ... 2022. Also, a six-year historic analysis is provided for ...
Breaking Medicine Technology: