Navigation Links
New Gene Linked to Congenital Heart Defects
Date:5/4/2011

WEDNESDAY, May 4 (HealthDay News) -- A gene essential to cardiac development has been associated with a group of congenital heart defects that cause a major proportion of childhood death from heart abnormalities.

It is unclear how these cardiac defects -- all malformations of the left ventricular outflow tract (LVOT) -- develop. The new research suggests a genetic component may play a role.

"It is estimated that there are more than 500 genes that may be important in heart development," said lead investigator Dr. Kim McBride, from the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital and a faculty member at The Ohio State University College of Medicine. "Changes in any of these genes may impact how a child's heart forms."

Researchers at the Nationwide Children's Hospital set out to identify specific genes involved in cardiac development by examining the DNA of children treated for left ventricular outflow tract malformations and their parents. The study revealed a new link between the gene ERBB4 and specific LVOT defects.

Researchers said ERBB4 encodes a protein that serves as an "on" or "off" switch in many cellular functions during heart development.

"The precise defect in this very large gene is not yet known," said McBride. "ERBB4 now joins a previously identified gene, NOTCH1, as a susceptibility gene for LVOT defects. Replication of these results in other subjects will be required to better determine its role in the development of the heart malformations."

The LVOT defects include a narrowing of the aorta, a large blood vessel that branches off the heart, which causes it to pump abnormally hard (coarctation of the aorta) and a narrowing of the heart's aortic valve that obstructs normal blood flow (aortic valve stenosis).

They also include a rare heart defect in which the left side of the heart is severely underdeveloped (hypoplastic left heart syndrome), a set of four heart defects that cause inflow and outflow problems (Shone complex) and a very rare heart defect in which the aorta is not fully developed (interrupted aortic arch type).

The study appears in the journal Birth Defects Research Part A.

More information

The U.S. National Heart, Lung, and Blood Institute lists detailed information on congenital heart defects .

-- Mary Beth Dallas

SOURCE: Nationwide Children's Hospital, news release, April 29, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cotton Swabs Linked to Ruptured Eardrums, Study Shows
2. Insomnia linked to high insulin resistance in diabetics
3. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
4. Medical sleuthing linked muscle, kidney problems to kava tea
5. Being Housebound Linked to Alzheimers in Elderly
6. Mental Disorders Linked to Drug, Alcohol Abuse in U.S. Vets
7. Newer Pill Linked to Higher Risk of Blood Clots
8. Student Bullying Linked to Family Violence: CDC
9. Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids
10. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
11. Gene Variant May Be Linked to Deadly Lung Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Gene Linked to Congenital Heart Defects  
(Date:1/15/2017)... ... 2017 , ... "On Tour is a music themed slideshow production package which ... Austin - CEO of Pixel Film Studios. , On Tour’s new slide presets ... animation of their slideshows. Place each slide on top of another slide or piece ...
(Date:1/14/2017)... MN (PRWEB) , ... January 14, 2017 , ... ... present the distinctions among their expanding line of activated charcoal products. With more ... the importance of categorizing their products according to how they cater to specific ...
(Date:1/13/2017)... ... ... The 18th European Congress: Perspectives in Lung Cancer will be held in ... is expertly designed to meet the educational needs of European oncology clinicians and researchers ... Dr. Giorgio V. Scagliotti, Professor of Oncology at the University of Torino, and organized ...
(Date:1/13/2017)... ... January 13, 2017 , ... An inventor from Virginia Beach, Va., is always ... order to diversify my outfits, so he decided to design something that enhances the ... the appearance of a belt to allow for quick, easy changing of its look. ...
(Date:1/13/2017)... , ... January 13, 2017 , ... MyGenetx, a molecular ... Communications, and Sales Administration Specialist, Mary Taylor Smith, RD, LD, will serve on the ... serving one year as a board member and one year as Vice President. She ...
Breaking Medicine News(10 mins):
(Date:1/14/2017)... 14, 2017  Johnson & Weaver, LLP announces that a ... Zimmer Biomet Holdings, Inc. (NYSE: ZBH )  securities ... 2016 (the "Class Period"). Zimmer Biomet provides musculoskeletal ... reconstructive products, such as knee and hip reconstructive products. ... According to ...
(Date:1/13/2017)... New York , January 13, 2017 ... rising prevalence of AIDS will collectively contribute to the demand ... expected to reach a value of US$ 551.0 Mn by ... will remain the most lucrative markets for western blotting, ... lead the market globally. ...
(Date:1/13/2017)... , January 13, 2017 This ... see how they have fared at yesterday,s closing bell: ... Biopharma Inc. (NASDAQ: GALE ), and ACADIA ... harness cellular and biomolecular processes to develop technologies and ... environmental footprint, feed the hungry, use less and cleaner ...
Breaking Medicine Technology: