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New Gene Findings Will Help Guide Treatment in Infant Leukemia
Date:12/5/2009

ty to classify ALL based on specific partner genes of MLL may provide a new way to categorize which infants might benefit from specific types of treatment," said senior author Carolyn A. Felix, M.D., a pediatric oncologist and expert in infant leukemia at Children's Hospital, and a professor of Pediatrics at the University of Pennsylvania School of Medicine. "We also hope these findings will contribute to the development of new, molecularly targeted therapies for infants with this grim form of cancer that we seek to conquer."

Gregory Reaman, M.D., chair of the Children's Oncology Group, added, "As infants with ALL represent the group of children with the highest risk of treatment failure, despite successive attempts to intensify conventional therapy, these clues to potentially tailoring molecularly targeted treatment approaches are very exciting."

Major grant support for this research is from a Specialized Center of Research grant from the Leukemia & Lymphoma Society. Felix is the principal investigator of this multicenter grant, focused on developing innovative treatments for infant leukemia. Other major support came from a National Cancer Institute grant to the Children's Oncology Group.

Specific MLL Partner Genes in Infant Acute Lymphoblastic Leukemia (ALL) Associated with Outcome Are Linked to Age and White Blood Cell Count (WBC) at Diagnosis: A Report on the Children's Oncology Group (COG) P9407 Trial. Abstract 907, to be presented at the 51st Annual Meeting of the American Society of Hematology, Dec. 8, 2009.

About the Children's Oncology Group: The Children's Oncology Group (COG) is the world's largest cooperative pediatric cancer research organization. It includes every recognized pediatric cancer program in North America, comprising a network of more than 5,000 physicians, nurses, and other clinical and laboratory investigators.

About The Children's Hospital of Philadelphia:
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SOURCE The Children's Hospital of Philadelphia
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