Navigation Links
New Gel Treats Precancerous Skin Condition in Days: Study
Date:3/14/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, March 14 (HealthDay News) -- A newly approved gel appears effective in treating a condition called actinic keratosis, which is a common precursor to squamous cell skin cancer, a new study finds.

Earlier topical treatments took weeks or even months to treat the condition, but the new product -- Picato (ingenol mebutate) gel -- can work in a matter of days, according to the report in the March 15 issue of the New England Journal of Medicine.

"There are a number of agents available to treat precancerous skin lesions," said study author Dr. Mark Lebwohl, a professor and chairman of dermatology at Mount Sinai School of Medicine in New York City.

"Most of the other ones are applied over a period of weeks to months and have a reaction that lasts for a long time, so it interferes with your life for a good period of time. This one is unique in that it is applied for only one to three days," he said.

The U.S. Food and Drug Administration approved Picato for use on actinic keratoses in January. The new study was funded by LEO Pharma, the maker of Ingenol.

For the study, more than 900 people with actinic keratoses on their face or scalp, or elsewhere on their body (trunk, arms or legs) were randomly assigned to treatment with either Picato or an inactive placebo.

The researchers found that when used on the face or scalp, the gel cleared the condition nearly 43 percent of the time, compared with nearly 4 percent for the placebo.

When used on the trunk or extremities, the gel was again more effective than placebo -- about 34 percent for the gel versus nearly 5 percent for the placebo, the study authors noted.

Local skin reactions such as redness and crustiness developed within several days, but were gone quickly, and side effects were mild to moderate and went away without any problem, according to the report.

And because treatment takes less time, patients are more likely to adhere to their treatment, said study co-author Dr. Neil Swanson, director of dermatologic surgery at Oregon Health and Science University in Portland.

"It is an option to treat these lesions, a good percentage of which will go on to evolve to skin cancer," Swanson said.

In addition to skin gels, doctors treat actinic keratosis in other ways that include burning or scraping with an electric or laser device, cutting the tumor out, or freezing the tumor in a procedure called cryotherapy.

Commenting on the study treatment, Dr. Doris Day, a dermatologist at Lenox Hill Hospital in New York City, said that "it is efficacious and it's good for patients who can't tolerate other treatment."

However, Day said she would most likely use this gel in combination with other methods to treat the condition.

"I don't think I would use it as monotherapy," she said. "I don't think it penetrates deeply into the skin. So I would mix this with my other treatments such as laser and cryotherapy."

Day stressed that it is important to treat actinic keratosis before it becomes skin cancer.

More information

To learn about actinic keratosis, visit the U.S. National Library of Medicine.

SOURCES: Mark Lebwohl, M.D., professor and chairman of dermatology, Mount Sinai School of Medicine, New York City; Neil Swanson, M.D., director, dermatologic surgery, Oregon Health and Science University, Portland; Doris Day, M.D., dermatologist, Lenox Hill Hospital, New York City; March 15, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Aderans Research Treats One-Hundredth Subject in Clinical Study
2. High-fat ketogenic diet effectively treats persistent childhood seizures
3. Ayurvedic Cooking, Massages and Yoga -- Relaxing for Children Charity -- Retreats at an Ashram in India
4. Combining radiation therapy, chemotherapy safely treats head and neck cancer patients
5. Those Sweet Pet Treats May Foster Fatness
6. In U.S., Salmonella Is on the Rise While E. Coli Retreats
7. New Drug Effectively Treats Hepatitis C
8. New procedure treats atrial fibrillation
9. Radiofrequency ablation safely and effectively treats Barretts esophagus
10. Paired drugs kill precancerous colon polyps, spare normal tissue
11. New form of endoscopic scanning improves detection of precancerous condition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Gel Treats Precancerous Skin Condition in Days: Study
(Date:5/6/2016)... ... ... Overseer at The House of Yahweh, has written a new article this week meant to ... stop cancer. Yisrayl says there are too many suffering and dying from the disease to ... pay close attention and take action. The Pastor says that the root cause of all ...
(Date:5/6/2016)... MOOREFIELD, W.V. (PRWEB) , ... May 06, 2016 , ... ... by WestBow Press) shares accounts of dying patients who have allowed those holding vigil ... June E. Kuykendall, RN, BSN, CHPN, hopes to help readers spiritually and practically gain ...
(Date:5/5/2016)... PA (PRWEB) , ... May 05, 2016 , ... ... on long-acting injectables (LAIs), today announced a development collaboration with the ... to treat serious mental disorders such as schizophrenia. , LAI medicines can offer ...
(Date:5/5/2016)... ... May 05, 2016 , ... TLC Laser Eye Centers announced today that ... eye center will now be called “Gordon Schanzlin New Vision Institute, a TLC Laser ... the full-service facility to ensure that patients continue to receive the highest quality of ...
(Date:5/5/2016)... ... 2016 , ... LELO has discovered many people are insecure about ... via email, social media and on the Volonté blog seeking advice about how to ... ‘normal’ or ‘correct’?” , While some methods are more common than others, there is ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... May 5, 2016  Diagnostic imaging has been ... to concerns that these tests cause health care costs to ... imaging, as well as the adoption of new ... medical peripherals that help health care providers cut costs, while ... medical imaging is a renowned authorized reseller of the ...
(Date:5/5/2016)... 5, 2016 Research ... "Europe Thalassaemia Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... and Competitive Landscape Highlights - 2016, provides ... epidemiology, Thalassaemia market valuations and forecast, Thalassaemia ...
(Date:5/4/2016)... NESS ZIONA, Israel , May ... BVXV, TASE: BVXV) announced today that BiondVax,s CEO, Dr. ... 2016 conference in New York City . ... presenting at 10:30am at Pioneers 2016, a conference presented by ... New York Palace Hotel. The BiondVax presentation that ...
Breaking Medicine Technology: