Navigation Links
New England Journal of Medicine hails new skin cancer drug as 'greatest advance yet'
Date:6/13/2012

SCOTTSDALE, Ariz. June 12, 2012 Vismodegib, a new skin cancer drug for patients with advanced basal cell carcinoma tested by TGen, Virginia G. Piper Cancer Center at Scottsdale Healthcare and Mayo Clinic, is hailed as "the greatest advance in therapy yet seen" for advanced basal cell carcinoma in an editorial in the New England Journal of Medicine.

Vismodegib (marketed under the name Erivedge) was administered for the first time in the world on Jan. 23, 2007 in a Phase I clinical trial at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership with the Translational Genomics Research Institute (TGen).

This is the first drug tested under the Scottsdale Healthcare-TGen partnership to receive FDA approval, and is the first to receive FDA approval to treat inoperable basal cell carcinoma. Successful early trial results led to additional study sponsored by Genentech.

The successful Phase I study at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, headed by Scottsdale Healthcare Chief Scientific Officer and TGen Physician-In-Chief Daniel Von Hoff, M.D, led to a broader study, published June 7 by the New England Journal of Medicine.

"The first patient put on this drug had advanced basal cell cancer, so we suspected that the tumor had the mutation this drug is targeted against," said Ramesh K. Ramanathan, M.D., Medical Director at Virginia G. Piper Cancer Center Clinical Trials and Clinical Professor and Deputy Director of the Clinical Translational Research Division at TGen. "And our partnership with Dr. Ronald Korn and his team who did advanced PET imaging helped to really demonstrate the drug's efficacy for Genentech to continue pursuing the additional study."

The follow-up study, a Phase 2 clinical trial of basal cell carcinoma (BCC), was headed by Dr. Aleksandar Sekulic, Assistant Professor of Dermatology for the Mayo Clinic in Arizona, and an A
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Red Tide Likely in New England This Season, Experts Warn
2. Elsevier, SVS announce 2013 launch of Journal of Vascular Surgery: Venous and Lymphatic Disorders
3. NAMS journal Menopause reflects on the WHI 10 years later
4. Reactions to HIV drug have autoimmune cause, reports AIDS journal
5. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
6. Journals and pharma collaborate on new recommendations
7. Model for breast cancer rehab featured in supplement to ACS journal, Cancer
8. Piramal imaging to present data at Society for Nuclear Medicine Annual Meeting
9. Surgeon General receives 2012 Distinguished Public Service Award from internal medicine physicians
10. Nanomedicines promise fewer side effects in treating cancer
11. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 As kinship care continues ... who cannot live with their parents, emphasis on kinship ... to enhance services and supports for kinship caregivers and ... National Kinship Care Conference is being held this week ... best practice, policy, program and service development for kinship ...
(Date:9/17/2014)... Final Cut Pro X plugin developers have ... Pixel Film Studios. , “ProBlue 5k is a compilation of ... to epic,” said Christina Austin, CEO of Pixel Film Studios. ... a definite game changer.” , ProBlue 5k is the ultimate ... filmmaker ! This footage compilation of over 100 anamorphic flares ...
(Date:9/17/2014)... first-of-its-kind research study was announced today that will ... impact long-term wellness and contribute to healthy aging. ... Center and funded through a $10 million unrestricted ... Fund, WELL aims to identify lifestyle and environmental ... and wellness as they age. WELL will be ...
(Date:9/17/2014)... September 17, 2014 In its latest blog ... and believes that having family close by during a stay ... not the process is successful, is highlighting a member of ... in the lives of addicts across the country and around ... therapy can reduce the blood pressure, heart rate, and stress ...
(Date:9/17/2014)... these sound like the ideas of a ... components of an exciting new approach to imaging ... of metastatic prostate cancer, scientists at Virginia Commonwealth ... Medicine and Johns Hopkins Medical Institutions have provided ... could revolutionize doctors, ability to see tumors that ...
Breaking Medicine News(10 mins):Health News:Arizona’s Children Association Kinship Service Providers Invited to Present at the CWLA National Conference 2Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:First-ever research study examines impacts of diet and lifestyle on healthy aging 2Health News:Latest Best Drug Rehabilitation Blog Post Highlights How Dogs are Helping Addicts Recover 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 3
... of Economy, Vet Difficulties Demonstrate Urgency; Advances in ... Mental Health America, the country,s oldest and ... mentally healthier lives, today called for action on ... for Mental Health."To view the Multimedia News Release, ...
... Customers; Reaches 400,000 Live User Milestone; Named #1 SSO ... identity and access management (IAM) solutions are the most ... the best performance in the Company,s history. In ... new user licenses. In addition, the Company reached ...
... at the University of Texas Medical Branch at Galveston ... fever virus uses to disarm the defenses of infected ... in humans, inflicting liver damage, blindness and even death ... Rift Valley fever also afflicts cattle, goats and sheep, ...
... N.M., Feb. 17 Exagen Diagnostics, Inc., which ... for research and analytic specific reagents to clinical ... Alsobrook, Ph.D., has been named vice president and ... oversees Exagen,s day-to-day operations, company alliances and genomic ...
... Effect on Executive Function and Functional Capacity are ... According to a New Report from Decision ResourcesWALTHAM, ... the world,s leading research and advisory firms for ... drug were to receive formal regulatory approval for ...
... procedure rooms offer faster and more accurate diagnosis and ... Medical Center today announces the completion of its state-of-the-art ... Now located on the second level of the ... with three fully functional state-of-the-art catheterization labs (cath labs) ...
Cached Medicine News:Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 2Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 3Health News:Video: On 100th Anniversary, Mental Health America Declares 'It's Time for Mental Health' 4Health News:Sentillion Announces 2008 as the Best Year in the Company's History 2Health News:Sentillion Announces 2008 as the Best Year in the Company's History 3Health News:Scientists uncover secrets of potential bioterror virus 2Health News:Exagen Diagnostics Names John Alsobrook, Ph.D., Vice President and Chief Operating Officer 2Health News:A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe 2Health News:A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe 3Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 2Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 3Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 4Health News:St. Mary Medical Center Opens New Cardiovascular Catheterization Labs Reaffirming Role as a Regional Leader in Cardiovascular Medicine 5
(Date:9/17/2014)... 17, 2014  Decision Resources Group finds ... eligible for biologic therapy, only a proportion ... gastroenterologists cite patients, discomfort with biological therapy ... rates, followed by cost-related issues and payer ... biologics, Janssen Biotech,s Remicade and AbbVie,s Humira ...
(Date:9/17/2014)... -- Bronstein, Gewirtz & Grossman, LLC is investigating potential ... PDL BioPharma, Inc. ("PDL BioPharma" or the "Company") (NasdaqGS: ... to contact Peretz Bronstein or his investor ... or 212-697-6484. The investigation focuses on ... federal securities laws. On September 16, 2014, ...
(Date:9/17/2014)... PRAIRIE, Minn. , Sept. 17, 2014 ... and global market leader of advanced imaging modalities for ... Ultrasound System in two live cases at the Transcatheter ... The cases were presented from Medstar Washington Hospital ... York-Presbyterian Hospital/Columbia University Medical Center ( New York, ...
Breaking Medicine Technology:The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3Shareholder Alert: Bronstein, Gewirtz & Grossman, LLC Investigates claims on behalf of Investors of PDL BioPharma, Inc. --PDLI 2ACIST Launches HDi High-Definition IVUS 2ACIST Launches HDi High-Definition IVUS 3
... , JERUSALEM , Jan. ... company, announced today that it has granted Novartis an option to ... Permeability Enhancer (TPE) technology for use with certain related small molecule ... a separate but related agreement, the MPM Bio IV NVS Strategic ...
... , FRANKLIN LAKES, N.J. , Jan. 19 ... scheduled to present at the following investor conferences: , Brian Griffin ... Global Healthcare Services Conference on Monday, January 25, 2010 at ... New York ; , David B. Snow Jr. , Medco chairman ...
Cached Medicine Technology:Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 2Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 3Medco to Present at Upcoming Investor Conferences 2
... key clinical and economic issues of cerclage ... designed to maximize tension control while minimizing ... combines efficient instrumentation with a simple technique. ... is indicated for general orthopaedic trauma surgery ...
OmniAccess&trade Hip Retractor System sets a new standard in hip exposure. It provides constant, absolute exposure of the acetabulum during total hip arthroplasty and revision procedures....
... Many of DePuy's aggressive innovations have become ... to be equalled. The AML Total ... to efficiently address and effectively meet the ... arthroplasty. With greater than 15 years ...
The Endotrac™ System includes an Obturator, Slotted Cannula, Synovial Elevator, Ligament Probe, Ligament Rasp, Blade Handle, two Retractors and sterilizable tray. The Endotrac&trade....
Medicine Products: