Navigation Links
New Drugs No Better Than Older Ones for Schizophrenia
Date:3/28/2008

However, patients stay on the new medications longer, study finds

FRIDAY, March 28 (HealthDay News) -- Newer, so-called second-generation antipsychotics are no better than the older drug haloperidol in treating a first episode of schizophrenia, a new study finds.

However, it appears that more patients prefer the newer drugs and are more likely to continue using them than haloperidol, the study authors said.

"When we compared newer drugs to older drugs, we found that patients stay longer on the new drugs," said lead researcher Dr. Rene Kahn, a professor of psychiatry at the University Medical Centre Utrecht in the Netherlands.

Earlier studies had found 70 percent of schizophrenia patients stopped taking the older antipsychotics. In the new study, 70 percent of patients kept with the newer drugs, Khan noted.

"The biggest reason that they stayed longer was that doctors perceived the newer drugs as more efficacious," Khan said. "That's the way real life is -- real life is that patients and doctors perceive their medication to have a certain efficacy."

But, if you look at improvement in symptoms and the number of times patients were hospitalized after the first treatment, then the drugs did not differ, Khan said.

The findings are published in the March 29 issue of The Lancet.

Kahn's team randomly assigned 498 patients to haloperidol, or higher-dose second-generation drugs that included amisulpride, olanzapine, quetiapine and ziprasidone.

Over the following year, 63 patients discontinued haloperidol, compared with 32 who stopped using amisulpride, 30 who stopped using olanzapine, 51 who quit quetiapine and 31 who stopped taking ziprasidone, the researchers found.

However, regardless of which medication the patients were taking, 60 percent saw a reduction in their symptoms, the researchers found. And, when the researchers looked at gender, and side effects such as suicidal behavior and substance abuse, they didn't find any significant difference among the drugs.

The hopeful sign is that patients taking the newer drugs stayed on them longer, Khan said.

"Overall, we should be encouraged that if we give the patients the right drug, that in 60 to 70 percent of the cases, they still stay on the medication," Khan said. "We should not be so pessimistic, as earlier studies suggested, that we cannot treat schizophrenia because only 30 percent of the patients stayed on the drug."

Dr. Robert A Rosenheck, a professor of psychiatry at Yale University School of Medicine and author of an accompanying editorial in the journal, said the only way to test whether patients prefer the newer drugs to the older ones is to have an objective trial in which patients and doctors don't know who's getting which drug.

"In terms of the main outcome of how long patients stayed on their drugs, the study showed a benefit for the newer drugs," he said. But, since the doctors knew which drugs were being given, the study results likely reflected the doctors' opinions of the drugs, he added.

The study began in 2002, Rosenheck noted, when there was a lot of enthusiasm for these new drugs. "The assumption of many doctors was, 'I want my patients on newer drugs as soon as possible,' " he said.

"The only way you get an objective assessment is by doing a study in which you can be sure neither the patient nor the physician knows which drug it is. So, they are just judging by the clinical outcomes. That's the standard for evaluating drugs," Rosenheck said.

More information

For more on schizophrenia, visit the U.S. National Institute of Mental Health.



SOURCES: Rene Kahn, M.D., Ph.D., professor of psychiatry, University Medical Centre, Utrecht, the Netherlands; Robert A. Rosenheck, M.D., professor of psychiatry, Yale University School of Medicine, New Haven, Conn.; March 29, 2008, The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Americans Guess One-Third of Professional Athletes on Performance Enhancing Drugs
2. Increasing access to antiretroviral drugs would drastically cut AIDS deaths in South Africa
3. Drugs Approved Under Deadline More Likely to Run Into Trouble Later
4. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
5. PCMA: Independent Drugstore Lobbys Prompt Pay Agenda Could Cost Medicare $3.3 Billion Over the Next Decade
6. China Nepstar Chain Drugstore Announces Dividend
7. Significant Generic Erosion Will Cause Sales of Dyslipidemia Drugs to Decline by $3.6 Billion by 2016
8. China Nepstar Chain Drugstore Reports 231.5% Increase in Net Income and Record Gross Margin of 48.5% for Fourth Quarter 2007
9. Baxa Corporation Announces Safe Handling and Preparation of Hazardous Drugs Course Offering at its STAR Center Training Facility
10. Wal-Mart Saves Customers More Than $1 Billion On Prescription Drugs
11. FDA Panel Supports Anemia Drugs for Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drugs No Better Than Older Ones for Schizophrenia
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
Breaking Medicine Technology: