Navigation Links
New Drugs No Better Than Older Ones for Schizophrenia
Date:3/28/2008

However, patients stay on the new medications longer, study finds

FRIDAY, March 28 (HealthDay News) -- Newer, so-called second-generation antipsychotics are no better than the older drug haloperidol in treating a first episode of schizophrenia, a new study finds.

However, it appears that more patients prefer the newer drugs and are more likely to continue using them than haloperidol, the study authors said.

"When we compared newer drugs to older drugs, we found that patients stay longer on the new drugs," said lead researcher Dr. Rene Kahn, a professor of psychiatry at the University Medical Centre Utrecht in the Netherlands.

Earlier studies had found 70 percent of schizophrenia patients stopped taking the older antipsychotics. In the new study, 70 percent of patients kept with the newer drugs, Khan noted.

"The biggest reason that they stayed longer was that doctors perceived the newer drugs as more efficacious," Khan said. "That's the way real life is -- real life is that patients and doctors perceive their medication to have a certain efficacy."

But, if you look at improvement in symptoms and the number of times patients were hospitalized after the first treatment, then the drugs did not differ, Khan said.

The findings are published in the March 29 issue of The Lancet.

Kahn's team randomly assigned 498 patients to haloperidol, or higher-dose second-generation drugs that included amisulpride, olanzapine, quetiapine and ziprasidone.

Over the following year, 63 patients discontinued haloperidol, compared with 32 who stopped using amisulpride, 30 who stopped using olanzapine, 51 who quit quetiapine and 31 who stopped taking ziprasidone, the researchers found.

However, regardless of which medication the patients were taking, 60 percent saw a reduction in their symptoms, the researchers found. And, when the researchers looked at gender, and side effects such as suicidal behavior and substance abuse, they didn't find any significant difference among the drugs.

The hopeful sign is that patients taking the newer drugs stayed on them longer, Khan said.

"Overall, we should be encouraged that if we give the patients the right drug, that in 60 to 70 percent of the cases, they still stay on the medication," Khan said. "We should not be so pessimistic, as earlier studies suggested, that we cannot treat schizophrenia because only 30 percent of the patients stayed on the drug."

Dr. Robert A Rosenheck, a professor of psychiatry at Yale University School of Medicine and author of an accompanying editorial in the journal, said the only way to test whether patients prefer the newer drugs to the older ones is to have an objective trial in which patients and doctors don't know who's getting which drug.

"In terms of the main outcome of how long patients stayed on their drugs, the study showed a benefit for the newer drugs," he said. But, since the doctors knew which drugs were being given, the study results likely reflected the doctors' opinions of the drugs, he added.

The study began in 2002, Rosenheck noted, when there was a lot of enthusiasm for these new drugs. "The assumption of many doctors was, 'I want my patients on newer drugs as soon as possible,' " he said.

"The only way you get an objective assessment is by doing a study in which you can be sure neither the patient nor the physician knows which drug it is. So, they are just judging by the clinical outcomes. That's the standard for evaluating drugs," Rosenheck said.

More information

For more on schizophrenia, visit the U.S. National Institute of Mental Health.



SOURCES: Rene Kahn, M.D., Ph.D., professor of psychiatry, University Medical Centre, Utrecht, the Netherlands; Robert A. Rosenheck, M.D., professor of psychiatry, Yale University School of Medicine, New Haven, Conn.; March 29, 2008, The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Americans Guess One-Third of Professional Athletes on Performance Enhancing Drugs
2. Increasing access to antiretroviral drugs would drastically cut AIDS deaths in South Africa
3. Drugs Approved Under Deadline More Likely to Run Into Trouble Later
4. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
5. PCMA: Independent Drugstore Lobbys Prompt Pay Agenda Could Cost Medicare $3.3 Billion Over the Next Decade
6. China Nepstar Chain Drugstore Announces Dividend
7. Significant Generic Erosion Will Cause Sales of Dyslipidemia Drugs to Decline by $3.6 Billion by 2016
8. China Nepstar Chain Drugstore Reports 231.5% Increase in Net Income and Record Gross Margin of 48.5% for Fourth Quarter 2007
9. Baxa Corporation Announces Safe Handling and Preparation of Hazardous Drugs Course Offering at its STAR Center Training Facility
10. Wal-Mart Saves Customers More Than $1 Billion On Prescription Drugs
11. FDA Panel Supports Anemia Drugs for Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drugs No Better Than Older Ones for Schizophrenia
(Date:2/10/2016)... ... February 10, 2016 , ... The recreational use of marijuana has been legal ... face a lot of restrictions as to where they can smoke pot. , ... and that cannabis “may not be consumed openly or publicly.” , Given the momentum ...
(Date:2/10/2016)... Tennessee (PRWEB) , ... February 09, 2016 , ... A ... reins for Summer 2016. FHU President Joe Wiley made the announcement Monday night, Feb. ... Brad Montague, a 2003 graduate of FHU and the creator of GO! Camp, has ...
(Date:2/10/2016)... ... February 09, 2016 , ... Ross A. Clevens, MD, ... to welcome a new addition to their growing practice. Beginning this month, Teresa ... nurse practitioner performing cosmetic procedures including injectables, fillers and laser treatments. ...
(Date:2/10/2016)... ... 09, 2016 , ... Traumatic Brian Injury is often in ... one of many possible sources: sports, car accidents, falls, work accidents, combat and ... Rehab Solutions for the Complexities of Concussions is designed for physical and ...
(Date:2/9/2016)... ... February 09, 2016 , ... Steven Douglas Associates is a sponsor of the ... upscale fundraiser held in South Florida. The Inaugural What’s Your Taste event will have ... event will be held in a new, more causal format at the Fort Lauderdale ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... 2016  Visage Imaging Inc. ("Visage"), a wholly ... announced that the American College of Radiology (ACR) ... the Visage 7 Enterprise Imaging Platform as the ... Imaging SIMulation (SIM). SIM is the assessment component ... a multi-faceted and fully-integrated online assessment, education and ...
(Date:2/10/2016)... Jersey and OR AKIVA, Israel ... Regentis Biomaterials Ltd., a leader in the ... Series D investment round on February 5, 2016. The ... Group ("Haisco"), a leading Chinese pharmaceutical manufacturer, and ... SCP Vitalife Partners, Generali Financial Holdings and both the ...
(Date:2/10/2016)... , Feb. 10, 2016  Silicon Biosystems ... and products that help uncover the biological complexities ... Biosciences Inc., a developer of innovative technologies for ... co-marketing partnership aimed at enabling translational researchers to ... a couple hundred tumor and normal cells in ...
Breaking Medicine Technology: