Navigation Links
New Drugs, New Combinations Fight Breast Cancer
Date:12/11/2009

Targeted therapies could make inroads against metastatic disease, researchers say

FRIDAY, Dec. 11 (HealthDay News) -- New therapies and new spins on existing treatments are offering hope for patients with breast cancer, especially those with metastatic disease, according to research being presented this week at the annual San Antonio Breast Cancer Symposium in San Antonio, Texas.

One study found that a higher (500-milligram) dose of Faslodex (fulvestrant) works better than the currently approved 250-milligram dose in hormone receptor-positive breast tumors that had already spread to other parts of the body. There was no difference in the severity of side effects between the two doses, researchers added.

Many breast cancer cells are sensitive to circulating estrogen because they carry receptors on their surface that link up with the hormone, helping malignant cells to spread and grow. Faslodex targets this critical link-up.

"This drug is different from other hormonal agents. It can actually destroy the estrogen receptor," explained study lead author Dr. Angelo Di Leo, director of the department of oncology at the Hospital of Prato in Italy. "Evidence from past clinical trials suggests that if you increase the dose of the drug you can induce a more profound down-regulation of the estrogen receptor."

And, in the new trial, that turned out to be the case.

"It was clear that 500 milligrams was more effective than 250 in prolonging time to disease progression and the median time to progression, which was 6.5 months for those in the 500-milligram group versus 5.5 months in the 250-milligram group," she said.

There was no evidence of tumor shrinkage but there was a hint that survival was also improved, but this was not statistically significant.

Dr. C. Kent Osborne, president of the symposium and moderator of a Friday teleconference detailing these and other findings, and director
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
2. Targeting gut bugs could revolutionize future drugs, say researcher
3. HIV drugs, Abacavir and Didanosine increase the risk of heart attack
4. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
5. Drugs, Doctors and Death: Heath Ledger Becomes Another Victim
6. Cure Diabetes with Weight Loss, Not Drugs, Expert Says
7. Gene expression differences between Europeans and Africans affect response to drugs, infections
8. Whats in a Name? When It Comes to Drugs, Plenty
9. When It Comes to Prescription Drugs, Get Smart
10. Biologic Drugs, Particularly Centocor/Janssen-Cilags Stelara and Abbott/Eisais Humira, will Drive the Psoriasis Drug Market to $5 Billion by 2017
11. Dubious Drugs, Tainted Foods Top 2008s Health Stories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... key to more youthful immune function might already be ... the Journal of Leukocyte Biology ... mice had different responses to Mycobacterium tuberculosis ... reversed by ibuprofen. , "Inflammation in old age can ... Ph.D., a researcher involved in the work from the ...
(Date:9/2/2014)... 02, 2014 According to a ... the leading global authority in medical device market ... is expected to grow to over €2 billion ... increase in the number of procedures for the ... This market includes TURP devices, laser BPH devices, ...
(Date:9/2/2014)... 2014 Nanomedicine is essentially based ... treating and/or prevention of diseases and infections. Nanotechnology-based ... neurological, and oncology diseases. , Nanomedicine is ... various nanoparticles, their medical usages, and their actions ... scope for research in this domain, and scientists ...
(Date:9/2/2014)... September 02, 2014 On Saturday, September 6, ... and fitness fair ¡Vive tu vida! Get Up! Get Moving!®. ... for better health and wellness for people of all ages ... to the public, will be held at Kiest Park Recreation ... to 1:00 pm. , “Since 2007, we have partnered ...
(Date:9/2/2014)... Durable Medical Goods manufacture ThermoTek , announced ... company LeaseQ, Inc. to help customers acquire capital goods ... LeaseQ’s breakthrough finance shopping platform has enabled businesses to ... run their business. , Said LeaseQ Vice President ... sales team to provide customers faster access to capital ...
Breaking Medicine News(10 mins):Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 2Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 3Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 2Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 3Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Medical Technology Manufacturer ThermoTek Announces New Partnership with LeaseQ.com to Help More Customers Acquire Equipment Faster and Cheaper 2
... have found out the benefits of oral ZYVOX for ... bacterial infections. They compared data from 80 health care ... of Intravenous Vancomycin. The results show that oral tablets ... of money spent to health clinics compared to vancomycin. ...
... from Children’s Hospital of Boston have reconstructed defective ... researchers used amniotic fluid for growing the sections ... living tissues into lambs, while they were in ... used for altering birth defects. Undifferentiated stem cell ...
... a life of dignity with access to medicines and care ... cancer, say experts on the eve of World Hospice and ... states like Kerala, Maharashtra, Karnataka and Orissa as well as ... administer strong pain killers that make life more bearable., ...
... is calling for concerted action following the recent release ... (WHO). // ,"Preventing Chronic Diseases: A ... global burden of chronic diseases including cardiovascular disease, cancer, ... global action to prevent chronic disease could save the ...
... total abdominal hysterectomy and laparoscopically assisted vaginal hysterectomy ... the advantages of lower morbidity // and faster ... vaginal route, although there is a high feasibility ... gynecologists need to be familiar with surgical techniques. ...
... and obstructive sleep apnea share some common symptoms, due to ... diagnosis. Obstructive sleep apnea (OSA) occurs when the tongue or ... the airway. This can happen more than 50 times an ... last as long as 60 seconds. The problem is twice ...
Cached Medicine News:Health News:Oral use of ZYVOX (Linezolid) is better to Intravenous Vancomycin use for Skin Infections 2Health News:Terminally Ill deserves a better quality of Life 2Health News:Terminally Ill deserves a better quality of Life 3Health News:Reversibility of symptoms of depression using CPAP in patients with obstructive sleep apnea 2
(Date:9/2/2014)... 2, 2014   Intrexon Corporation (NYSE: ... announced that it has entered into an Exclusive Channel ... of Sanofi (EURONEXT: SAN and NYSE: SNY ... specific family of its marketed Active Pharmaceutical Ingredients (APIs) ... . This collaboration will leverage Intrexon,s proprietary technology ...
(Date:9/2/2014)... Cepheid (NASDAQ: CPHD) announced today the release ... molecular test for rapid, accurate and reliable determination ... RSV infection. The test will be marketed as ... In Vitro Diagnostic Medical Devices, bringing ... Xpert Flu/RSV XC runs on Cepheid,s GeneXpert ® ...
(Date:9/2/2014)... -- Sinovac Biotech Ltd. (NASDAQ: SVA ), a leading ... today announced that the Company,s management will participate in the ... Global Healthcare Conference, to be held at the Grand Hyatt ... Morgan Stanley Asia Pacific Healthcare Day, to be held at ... Aegis Healthcare & Technology Conference, to be held at the ...
Breaking Medicine Technology:Intrexon Announces Exclusive Channel Collaboration with Sanofi to Optimize Production for a Specific Family of Active Pharmaceutical Ingredients 2Intrexon Announces Exclusive Channel Collaboration with Sanofi to Optimize Production for a Specific Family of Active Pharmaceutical Ingredients 3Cepheid Announces European Release of Xpert Flu/RSV XC for Accurate and Reliable Detection and Differentiation of Flu A, Flu B, and RSV Infection 2Cepheid Announces European Release of Xpert Flu/RSV XC for Accurate and Reliable Detection and Differentiation of Flu A, Flu B, and RSV Infection 3Cepheid Announces European Release of Xpert Flu/RSV XC for Accurate and Reliable Detection and Differentiation of Flu A, Flu B, and RSV Infection 4Sinovac to Participate in Upcoming Investor Conferences 2
... 28, 2011 Burg Simpson Eldredge Hersh & Jardine, P.C., ... delighted to announce that shareholder, Seth. A. Katz, has been ... a member of the Plaintiffs, Steering Committee in the multidistrict litigation ... ASR XL Acetabular Hip System. In August 2010, ...
... 28, 2011 Awarepoint Corporation, a privately held ... with 91 hospital sites contracted consisting of 45,062,013 ... network coverage in U.S. hospitals and 135,265 healthcare ... enterprise-wide U.S. hospital client base for RTLS in ...
Cached Medicine Technology:Burg Simpson Leads National Litigation Against DePuy Orthopaedics, Inc. 2Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 2Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 3Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 4
... only powered 6-inch dermatome on the market. ... adult hands or a small child's face ... to run more efficiently, thus the motor ... temperature is much cooler. The Electro-Dermatome is ...
A finely parallel striated (scratched) clear plastic membrane encapsulated between glass plates....
Corneal rust ring remover battery powered, extra burr 1.0 mm....
BD Visitec IOL Manipulator (Sinskey), blunt tip angled 45, 15.0 mm from end, fits 0.20 mm diameter holes and larger (3/bx, 1 bx/ca), sterile. For positioning intraocular lenses. Sure grip handles han...
Medicine Products: