Navigation Links
New Drug for Brain Cancer Too Dangerous for Pediatric Patients
Date:3/10/2008

eration. However, that same pathway regulates bone development.

Concerned that the drug might throw the baby out with the bathwater among younger patients, the researchers focused on mice between 10 and 14 days old, all genetically engineered to have cancer.

Several doses of HhAntag were tested over two-week treatment periods. The highest dose -- 100 mg/kg offered twice daily -- was found to be an ideal recipe for killing cancer.

However, X-rays revealed that after just two days, the therapy provoked widespread skeletal, cartilage and joint abnormalities, as well as impaired growth and weight loss. Even after cessation of treatment, the damage was irreversible.

Curran believes that the harsh STI consequences observed in young mice would be similarly manifested in children -- though to what degree remains unclear.

"So, for children we could potentially try to figure out how to deliver these drugs to the brain tumor and not the bones," he said. "But that will require a lot more research, which is unlikely to be performed by the pharmaceutical companies who wouldn't benefit financially, because the potential patient pool amounts to just a few hundred children per year for this kind of cancer."

"Without this research, we think the drug will only be useful for a subset of young patients," Curran noted. "Children with recurrent brain tumors, for example. Because, unfortunately, children who have relapsed don't live very long, and the side effects become irrelevant."

Dr. John S. Yu, co-director of the Comprehensive Brain Tumor Program at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute in Los Angeles -- shared Curran's concern.

"This study brings up a cautionary note for the long-term well-being of the young cancer patient," he said. "It certainly has significant repercussions for children with medullablastoma and other tumors that may be treatable with an expectation for a l
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Pain in fibromyalgia is linked to changes in brain molecule
2. National Museum of Health and Medicine hosts Brain Awareness Week 2008
3. Scientists determine structure of brain receptor implicated in epilepsy and PMT
4. New findings about the brain lead to treatment for eating disturbances
5. Brain network linked to contemplation in adults is less complex in children
6. Your brain on Krispy Kremes
7. Deficit in Brain Function Puts Teens at Risk of Drug Abuse
8. Brain Scans Let Computer Read Visual Activity
9. Neural progenitor cells as reservoirs for HIV in the brain
10. Maternal love: How a mothers brain responds to her infant
11. Breast cancer subtypes linked to survival from secondary brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug for Brain Cancer Too Dangerous for Pediatric Patients
(Date:12/22/2014)... December 22, 2014 Luxury Linen purveyor ... Partners of Dallas to provide logistics and support for ... Peacock Alley has a long history of giving back to ... sponsors of this year's Toy Drive were Whataburger® and 99.5 ... back than the holidays. Providing gifts to children who would ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 NAPW ... 2014 Professional Woman of the Year. She is recognized ... the largest, most recognized networking organization of professional women ... the National Association of Professional Women is a vibrant ... Local Chapters. , Ms. Kreider is passionate and committed ...
(Date:12/22/2014)... At the annual National League ... San Antonio, esteemed experts and thought leaders will ... in the way of successful organizational performance: resistance, ... faculty development opportunity is made possible through the ... to assist nurse educators to advance to leadership ...
(Date:12/21/2014)... Recently, BambooFlooringChina.com, a famous bamboo lumber ... flooring collection , and launched a bamboo flooring promotion ... valid until Jan. 30, 2015. , According to the ... hardest bamboo flooring available today; it has a highly ... teak hardwoods. Strand woven bamboo is made by a ...
(Date:12/21/2014)... Hills, Ca (PRWEB) December 21, 2014 ... Khanna was a guest at the Aspen Helicopters holiday ... kids and a Santa with sleigh, flown by an ... helicopter appeared invisible; only Santa with sleigh was visible.(please ... during day and night. Dr.Khanna has helped many pilots ...
Breaking Medicine News(10 mins):Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:National Association of Professional Women Announces Cheryl A. Kreider, President / CEO of Kreider Health Solutions, LLC, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... the Support of Long Term Care elects healthcare software expert Eric Christ ... ... -- The National Association for the Support of Long Term Care (NASL) ... the president of Patient Placement Systems , part of the Jackson ...
... start for career-building in today,s tough economic times. The chiropractic ... , ... (PRWEB) December 22, 2008 ... recruiting campaign targeting career changers and other potential students. During ...
... Free Ride Home Program on New Year,s Eve , ... Terre Haute, Ind. (PRWEB) December ... with Yellow Cab of Terre Haute to provide free transportation to those who ... Year,s Eve. The Safe and Sober Free Cab Ride Home program will be ...
... 22, 2008, Cambridge, UK ,New research sheds light ... Syndrome, an inherited developmental disorder in which patients have ... study published in the journal Disease Models & ... model to help explain a puzzling connection between Costello ...
... in metabolizing the most potent carcinogen found in cigarette ... That is the conclusion of a new study published ... , a peer-reviewed journal of the American Cancer Society. ... lung cancer develops and could have important implications for ...
... Woman recently fit with the most advanced non-surgical upper extremity ... biodesigns, selective compression-stabilization interface. Amputee now feels renewed feeling of ... , ... Santa Monica, CA (PRWEB) December ...
Cached Medicine News:Health News:Eric Christ of Long-Term Care Software Leader Patient Placement Systems' Elected to NASL Board of Directors 2Health News:Parker College of Chiropractic Education Launches Recruiting Campaign for Career Changers and Potential Students 2Health News:Fleschner, Stark, Tanoos & Newlin to Offer Free Terre Haute Cab Rides on New Year's Eve 2Health News:Fleschner, Stark, Tanoos & Newlin to Offer Free Terre Haute Cab Rides on New Year's Eve 3Health News:SNPs of ABC transporter genes linked to lung cancer risk 2Health News:California Woman Receives Most Advanced, Non-Invasive Upper Extremity Prosthetic Solution: Bionic i-LIMB Hand and Innovative Interface System Increase Amputee's Functionality and Confidence 2Health News:California Woman Receives Most Advanced, Non-Invasive Upper Extremity Prosthetic Solution: Bionic i-LIMB Hand and Innovative Interface System Increase Amputee's Functionality and Confidence 3Health News:California Woman Receives Most Advanced, Non-Invasive Upper Extremity Prosthetic Solution: Bionic i-LIMB Hand and Innovative Interface System Increase Amputee's Functionality and Confidence 4
(Date:12/19/2014)... DIEGO and CARDIFF-BY-THE-SEA, Calif. ... Inc. (NASDAQ: SRNE ;  Sorrento), an ... associated pain, and Conkwest, Inc., a privately-held immuno-oncology ... Natural Killer (NK) cell-line based therapy, announced today ... agreement to jointly develop next generation CAR-TNK™ (pronounced ...
(Date:12/19/2014)... 18, 2014 Somewhere between dropping five pounds ... forgotten. But Audicus , a next-generation hearing aids ... new year. Hearing loss is the third ... though it is often unaddressed. Forty-eight million Americans have ... hearing aid, mainly due to price. Hearing aids traditionally ...
(Date:12/19/2014)... 2014  Sage Analytics ( www.sageanalytics.com ), the ... the testing of marijuana potency and moisture content, ... Profiler, the industry,s first product suite capable of ... portable unit. Designed from the ground ... cannabis industry, the Luminary™ Profiler utilizes specially purposed ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Audicus Will Help People Resolve to Hear Better in 2015 2Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... Inc. (NASDAQ: PGNX) today announced positive,results from the ... in individuals infected with the human immunodeficiency,virus (HIV), ... 5.0 mg/kg dose of PRO 140 achieved an ... of 98.5% (1.83,log10), with individual reductions ranging up ...
... intramuscular injection of peramivir for eight,days protected mice ... replication, supporting the use of this drug to,control ... 2007 /PRNewswire-USNewswire/ -- The,antiviral drug peramivir might offer ... influenza virus H5N1, according to,results of mouse studies ...
Cached Medicine Technology:Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 2Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 3Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 4Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 5Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 6Progenics Announces Positive Results in Clinical Trial of Novel HIV,Therapy 7Peramivir Protects Mice From Lethal H5N1 Infection 2Peramivir Protects Mice From Lethal H5N1 Infection 3
Catalyst for skin rejuvenation. Rapidly exfoliates superficial skin problems....
... simple, effective, non-surgical treatment that works by ... reducing and smoothing away frown-lines and wrinkles., ... of clinical experience. Dysport was developed in ... to successfully treat a number of neurological ...
... 18 years ago, Zyderm® and Zyplast® injectable ... filler materials for smoothing facial lines, wrinkles ... definition. Treatments supplement the skins natural collagen, ... results. Today, more than one million people ...
... into the new age of non-surgical facial ... patients immediate, long-term results for various applications ... filler offers superior versatility for a wide ... Long-lasting, Radiesse saves time and money for ...
Medicine Products: