Navigation Links
New Drug Slows Advanced Kidney Cancer
Date:1/26/2010

Pazopanib may double time to disease progression, study finds

TUESDAY, Jan. 26 (HealthDay News) -- Treating advanced kidney cancer patients with the drug pazopanib (Votrient) slowed their disease progression by 54 percent, a new study has found.

The phase 3 study included 233 patients with previously untreated kidney cancer (also known as renal cell carcinoma) that was locally advanced or had spread, and 202 patients with renal cell carcinoma who had previously been treated with cytokine therapy (interferon or interleukin). The patients were randomly assigned to take pazopanib tablets (290 patients) or a placebo drug (145 patients).

In the pazopanib group, it took an average 9.2 months for the cancer to progress, vs. an average 4.2 months in the placebo group. The difference was greatest in previously untreated patients (11.1 months for the pazopanib group and 2.8 months for the placebo group), but also was found among patients previously treated with cytokines (7.4 months in the pazopanib group vs. 4.2 months in placebo group).

Common side effects of pazopanib treatment included diarrhea (52 percent), high blood pressure (40 percent), hair color changes (38 percent), nausea (26 percent), weight loss (22 percent) and vomiting (21 percent).

The data from this study, published online Jan. 25 in the Journal of Clinical Oncology, was used by the U.S. Food and Drug Administration to approve pazopanib in October 2009 for the treatment of advanced renal cell carcinoma.

Pazopanib inhibits the development of blood vessels that tumors need to grow and spread.

"Advanced renal cell carcinoma remains a challenging disease, but treatment has improved with the introduction of new targeted therapies over the past year -- including pazopanib, which targets multiple pathways within cancer cells," study author Dr. Cora Sternberg, chief of the medical oncology department at the San Camillo and Forlanini Hospital in Rome, Italy, said in a news release from the American Society of Clinical Oncology.

More information

The American Cancer Society has more about kidney cancer.



-- Robert Preidt



SOURCE: American Society of Clinical Oncology, news release, Jan. 25, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetic Variant Slows AIDS Progression
2. Wistar researchers show targeting normal cells in tumors slows growth
3. Drinking coffee slows progression of liver disease in chronic hepatitis C sufferers
4. Prime Therapeutics 2009 Drug Trend Insights Shows Drug Spending Slows to Lowest Rate on Record
5. Vaccine slows progression of skeletal muscle disorder
6. Male Cosmetic Surgery Slows Down While Female Cosmetic Surgery Advances
7. AIDS Drug Slows Spread of Deadly Childhood Brain Cancer
8. Chondroitin slows progression and relieves symptoms of knee osteoarthritis
9. Old gastrointestinal drug slows aging, McGill researchers say
10. Adult-onset diabetes slows mental functioning in several ways, with deficits appearing early
11. Vitamin K Slows Insulin Resistance in Older Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... Jacksonville, Fla. (PRWEB) , ... July 25, 2017 , ... ... employee and father Ezra Clark is taking advantage of a new benefit for employees ... “It really means a lot that the company supports me and other employees as ...
(Date:7/25/2017)... ... July 25, 2017 , ... SignatureCare Emergency Center – South ... TX area 24 Hours a day. , The Emergency Room opened ... “We’ve been open four months now and things are running smoothly,” said Aaron Braun, ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... , Robins & Morton, Perkins Will, Newcomb & Boyd, Walter P Moore ... the new Destination Medical Building located at Mayo Clinic in Jacksonville, Florida. ...
(Date:7/24/2017)... ... July 24, 2017 , ... SignatureCare Emergency Center is looking to ... fall semester to a deserving student. Get your applications in now as the ... to Mariana Castillo who is a nursing student at Prairie View A&M University with ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response to the Opioid ... Health Care Services, will facilitate the development of a hub and spoke model ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... -- Dr. Echenberg, founder of Echenberg Institute, is announcing a new safe and ... painful intercourse and other painful pelvic pain conditions such as pelvic floor ... ... ... -based start-up company, VuVatech LLC, fills a void in the women,s ...
(Date:7/10/2017)... , July 10, 2017  US medical equipment ... in 2021, according to Medical Equipment & ... by Freedonia Focus Reports. Continued increases in demand for ... aging of the population and supported by gains in ... equipment and supplies. New product introductions will also drive ...
(Date:7/10/2017)... , July 10, 2017  BDI Group subsidiary ... patient support services organization serving specialty pharmacies, home ... launch of four significant, value-added member programs designed ... better manage reimbursement and improve access and affordability ... therapies. ...
Breaking Medicine Technology: