Navigation Links
New Drug Shows Promise Against Certain Lung Cancers
Date:10/28/2010

By Jenifer Goodwin
HealthDay Reporter

WEDNESDAY, Oct. 27 (HealthDay News) -- An experimental cancer drug is proving effective in treating the lung cancers of some patients whose tumors carry a certain genetic mutation, new studies show.

Because the mutation can be present in other forms of cancer -- including a rare form of sarcoma (cancer of the soft tissue), childhood neuroblastoma (brain tumor), as well as some lymphomas, breast and colon cancers -- researchers say they are hopeful the drug, crizotinib, will prove effective in treating those cancers as well.

In one study, led by Dr. Eunice Kwak of Massachusetts General Hospital, researchers identified 82 patients from among 1,500 patients with non-small-cell lung cancer, the most common type of lung malignancy, whose tumors had a mutation in the anaplastic lymphoma kinase (ALK) gene.

Crizotinib targets the ALK "driver kinase," or protein, blocking its activity and preventing the tumor from growing, explained a study co-author Dr. Geoffrey Shapiro, director of the Early Drug Development Center and associate professor of medicine at Dana-Farber Cancer Institute and Harvard Medical School, Boston.

"The cancer cell is actually addicted to the activity of the protein for its growth and survival," Shapiro said. "It's totally dependent on it. The idea is that blocking that protein can kill the cancer cell."

In 46 patients taking crizotinib, the tumor shrunk by more than 30 percent during an average of six months of taking the drug. In 27 patients, crizotinib halted growth of the tumor, while in one patient the tumor disappeared.

The drug also had few side effects, Shapiro said. The most common was mild gastrointestinal symptoms.

"These are very positive results in lung cancer patients who had received other treatments that didn't work or worked only briefly," Shapiro said. "The bottom line is that there was a 72 percent chance the tumor would shrink or remain stable for at least six months."

The study is published in the Oct. 28 issue of the New England Journal of Medicine.

In recent years, researchers have started to think of lung cancer less as a single disease and more as a group of diseases that rely on specific genetic mutations called "driver kinases," or proteins that enable the tumor cells to proliferate.

That has led some researchers to focus on developing drugs that target those specific abnormalities. "Being able to inhibit those kinases and disrupt their signaling is evolving into a very successful approach," Shapiro said.

The good news is that drugs such as crizotinib seem to work well in patients with the mutation, noted Dr. Roman Perez-Soler, chairman of the department of oncology at Montefiore Medical Center and professor of medicine and molecular pharmacology at the Albert Einstein College of Medicine in New York City. But the bad news is that it means that patients who don't have the specific mutation won't be helped.

Only an estimated 2 percent to 7 percent of non-small-cell lung cancers have the ALK mutation, according to the study.

"This is great news for people with this type of tumor," Perez-Soler said. "Researchers have identified a group of patients, unfortunately a small group, who because of a very specific genetic abnormality are extremely sensitive to these targeted treatments and as a result of that can benefit from this drug without toxicity. It's very encouraging."

In a second study in the same journal, crizotinib was effective in a 44-year-old man with inflammatory myofibroblastic tumor, a rare form of sarcoma, which is also driven by the ALK abnormality, said Shapiro, who was senior author of that paper.

Still, there are caveats. Over time, tumors can adapt to such targeted therapy, eventually rendering it ineffective, experts said. In fact, a third study in the same journal identified ways in which lung cancers had already started to mutate and overcome crizotinib.

Moreover, while drugs targeting a specific tumor genotype are promising, there could be so many different genotypes that it would be impractical to come up with drugs targeting all of them, Perez-Soler said. Still other tumors might be fueled by multiple abnormalities.

"Many cancers may be much more complicated," he said. "And every tumor is different. Each one has a number of sophisticated ways to overcome interventions to block growth, and some may be better prepared than others to do that. That is why you see heterogeneity in the response to the drug. There is no such thing as identical twins when we talk about tumors."

Researchers are currently enrolling patients for a larger, Phase III clinical trial of crizotinib, Shapiro said. The study was funded by Pfizer, which is developing crizotinib for clinical application, and by grants from the U.S. National Cancer Institute, among others.

Lung cancer remains one of the most deadly cancers and new treatments are desperately needed, the researchers said. "Advanced lung cancer still remains a very lethal disease," Shapiro said. "It's the biggest cancer killer of both men and women in the U.S. and worldwide, and the unmet clinical need is extreme."

More information

Find out more about non-small-cell lung cancer at the U.S. National Cancer Institute.

SOURCES: Geoffrey Shapiro, M.D., Ph.D., director, Early Drug Development Center and associate professor, Dana-Farber Cancer Center and Harvard Medical School, Boston; Roman Perez-Soler, M.D., chairman, department of oncology at Montefiore Medical Center and professor, medicine and molecular pharmacology, Albert Einstein College of Medicine, New York, N.Y.; New England Journal of Medicine, Oct. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain cancer therapies success depends on presence of immune cell, Stanford study shows in mice
2. Targeted radiation therapy minimizes GI side effects for prostate cancer patients, Penn study shows
3. New Polio Vaccine Shows Major Advantages: Study
4. BUSM study shows patient navigations improve mammography rates in minority women
5. Study Shows HRT Even Riskier Than Thought
6. Adiponectin shows potential in blocking obesity-related carcinogenesis
7. National study shows 1 in 5 children meet criteria for a mental disorder across their lifetime
8. New Phase II study shows first-line promise of lung cancer drug PF-299
9. Pazopanib shows promise in Phase II trial for relapsed/refractory urothelial cancer
10. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
11. New Tool Shows Promise for Early Lung Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug Shows Promise Against Certain Lung Cancers
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
Breaking Medicine Technology: