Navigation Links
New Drug-Resistant 'Superbug' Reaches U.S. Shores

By Steven Reinberg
HealthDay Reporter

TUESDAY Sept. 14 (HealthDay News) -- A new antibiotic-resistant germ that apparently has it origins in India has sickened a handful of people in North America, with three of the cases reported in the United States, health officials said Tuesday.

But the bacterium -- designated New Delhi metallo-beta-lactamase NDM-1 -- is a close genetic cousin of another bacterium that's been present in the United States for many years. Both germs produce an enzyme that makes them resistant to a group of antibiotics called carbapenems, which include drugs such as penicillin and ampicillin.

"NDM-1 is a newly recognized mechanism of resistance that allows certain bacteria to become resistant to certain antibiotics," said Dr. Alexander J. Kallen, a medical epidemiologist and outbreak response coordinator with the U.S. Centers for Disease Control and Prevention's Division of Healthcare Quality Promotion.

"Unfortunately, carbapenem resistance is not uncommon even in the United States," Kallen added. "We have our own homegrown version of NDM-1 that has been recognized for quite a few years."

In the United States, carbapenem-resistant bacteria -- designated carbapenem-resistant carbapenemase (KPC) -- are usually transmitted in health-care facilities such as hospitals and nursing homes, and are typically spread from patient to patient from contaminated surfaces and hands, he said.

While none of the patients in the United States died from their infections with the NDM-1 germ from India, people should be very concerned about this new breed of germs that are showing resistance to carbapenem antibiotics, Kallen said.

"What is new in NDM-1 is a new mechanism that produces a strain [of bacterium] that looks the same as KPC," Kallen said.

NDM-1 appears to have started in India and is now found in countries such as Canada, Pakistan and some nations in Europe. Some people have died from their infections, but Kallen couldn't say how many.

In the United States, three cases have been reported. They were in Massachusetts, Illinois and California, Kallen said. None of the U.S. patients died from their infections, he said.

While NDM-1 is new, carbapenem resistance has been increasing, Kallen said.

How dangerous NDM-1 will become isn't known, Kallen said. But some studies have found the death rate from KPC [the North American bacterium] to be as high as 40 percent, he said.

Most of the transmission of the NDM-1 (Indian) and the KPC (North American) bacteria happen as infected people travel around the world, Kallen added. "These people carry with them all their antibiotic-resistant bacteria and that mechanism [travel] has been recognized lots of times, including with NDM-1 and KPC," he said.

Kallen said routine testing can reveal bacteria resistance. "As far as treating the patient or infection control, it doesn't matter what the mechanism is -- they're all bad and they all need to be controlled in the same way," he said.

Hospitals that identify cases of NDM-1 or KPC infection should isolate the patient before treatment. Hospitals should also check to see if other patients have had contact with infected patients.

One of the most common ways that bacteria become resistant to antibiotics is through the overuse of the drugs, Kallen noted.

Infectious diseases expert Dr. Marc Siegel, an associate professor of medicine at New York University in New York City, said that "the number of [NDM-1] cases is small, but what is concerning about this is this is a new bacteria that is emerging because of a genetic change that is causing a garden-variety bacteria to become resistant to most antibiotics."

Antibiotic-resistant bacteria are emerging because of lack of cleanliness and sterility in hospitals, too many antibiotics being prescribed, and drug companies not developing new antibiotics because they aren't profitable, Siegel said.

Dr. Pascal James Imperato, dean and distinguished service professor at the School of Public Health at SUNY Downstate Medical Center in New York City, explained: "Bacteria with this resistance capability are most likely to pose a problem first in hospitals. Some antibiotics are still effective against NDM-1. The first three cases in the U.S. were successfully treated. It is difficult to predict the future role of NDM-1 bacteria since they were only first detected in December, 2009."

More information

For more information on antibiotic resistance, visit the U.S. Centers for Disease Control and Prevention.

SOURCES: Alexander J. Kallen, M.D., M.P.H., medical epidemiologist and outbreak response coordinator, Division of Healthcare Quality Promotion, U.S. Centers for Disease Control and Prevention; Marc Siegel, M.D., associate professor, medicine, New York University, New York City; Pascal James Imperato, M.D., MPH, Dean and Distinguished Service Professor, School of Public Health, SUNY Downstate Medical Center, New York City

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Major funding awarded to improve treatment of drug-resistant tuberculosis and HIV co-infection
2. Drug-Resistant Staph Threatens Cystic Fibrosis Patients
3. Einstein awarded NIH grant to study drug-resistant TB
4. Rapid development of drug-resistant 2009 H1N1 influenza reported in 2 cases
5. Travel for Surgery May Help Spread New Superbug
6. New superbug surpasses MRSA infection rates in community hospitals
7. Americans With Disabilities Act Reaches 20th Anniversary
8. 20 Years of Good Digestion: Flora Source by Nutri-Health Reaches a Probiotic Milestone
9. TAO l: The Way of All Life, by Zhi Gang Sha Reaches #6 on New York Times Bestseller List
10. Talyst Reaches Major Milestone: 500 Implementations in Long-Term Care, Acute Care and Corrections
11. Health Savings Account Enrollment Reaches Ten Million
Post Your Comments:
(Date:11/30/2015)... Viejo, CA (PRWEB) , ... November 30, 2015 , ... ... Cut Pro X . Choose from scrolling web-styled transitions to wipes with blur ... colors, transition direction and more. Seamlessly transition from one clip to the next ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... and Attendance/Workforce Management cloud-based solutions, announced today that it has renewed the ... the Application Development, demonstrating a “best-in-class” ability and commitment to meet Microsoft’s ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... healthcare professionals worldwide today released the results of a survey of educational needs ... and Africa found a growing global demand for high quality online and face-to-face ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... to announce their strategic partnership at the Radiological Society of North America ... and Winscribe, global providers of cutting-edge dictation and speech-enabled documentation software, announced ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... announce their strategic partnership at the Radiological Society of North America (RSNA) ... global providers of cutting-edge dictation and speech-enabled documentation software, announced their partnership ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... and BOSTON , November 30, 2015 ... develop potential new medicines directed at up to 10 ... --> PFE ) to research and develop ... protein-coupled receptor (GPCR) targets across multiple therapeutic areas. ... drug discovery and development company and wholly-owned subsidiary of ...
(Date:11/30/2015)... Mexico Healthcare and Life Sciences Report 2015 . ... --> Pharmaboardroom releases its new 98-page Mexico Healthcare and ... , a country of over 122 million people. --> ... people. --> It offers companies, investors, policymakers, and stakeholders ... the second largest pharma and healthcare market in Latin ...
(Date:11/30/2015)... and REHOVOT, Israel , ... specialty pharmaceutical company focused on acquiring and developing innovative ... announced the appointment of Keith A. Katkin ... Gregory J. Flesher , chief executive officer for ... building successful organizations.  As chairman, he will be able ...
Breaking Medicine Technology: