Navigation Links
New Drug Promising Against Rheumatoid Arthritis

Golimumab might help where similar drugs failed, research finds

MONDAY, June 29 (HealthDay News) -- The immunosuppressive drug golimumab shows promise in treating rheumatoid arthritis patients who don't respond to other drugs, according to a new study. Golimumab is from the family of drugs called tumor necrosis factor-a (TNF-a) inhibitors.

The new study included 461 patients in 10 countries who were randomly selected to receive either injections of placebo, 50 milligrams of golimumab or 100 milligrams of golimumab. The injections were given every four weeks for 24 weeks.

After 14 weeks, 35 percent of patients taking 50 milligrams of golimumab and 38 percent of those taking 100 milligrams of the drug achieved a 20 percent or higher improvement in American College of Rheumatology criteria for assessment of rheumatoid arthritis (ACR 20), compared with 18 percent of patients taking the placebo.

The study also found that among the 58 percent of patients who had discontinued a previous TNF-a inhibitor treatment because it wasn't effective, ACR 20 was achieved by 36 percent of patients taking 50 milligrams of golimumab, 43 percent of those taking 100 milligrams of golimumab and 18 percent of those in the placebo group.

After 24 weeks of treatment, serious adverse events were recorded in five percent of patients taking 50 milligrams of golimumab, four percent of those taking 100 milligrams of the drug and in 10 percent of patients on placebo.

"Golimumab reduces the signs and symptoms of active rheumatoid arthritis and improves physical function in patients who had previously received TNF-a inhibitors, which suggests that switching patients from one TNF-a inhibitor to golimumab is effective and generally well-tolerated," wrote Josef Smolen of the Medical University of Vienna and Hietzing Hospital in Vienna, Austria, and colleagues.

In a commentary, Dr. Yusuf Yazici of New York University Hospital for Joint Diseases, New York City, said that "for those patients who have failed or had an inadequate response to etanercept, infliximab, adalimumab or abatacept, golimumab might be a good option."

The study, which was funded by drug makers Centocor, Inc. and Schering- Plough, appears online June 29 inThe Lancet.

Rheumatoid arthritis is a chronic inflammatory disease that affects about 1.3 million people in the United States. TNF-a inhibitors are widely used to treat the disease, but 30 to 50 percent of patients treated with these drugs are intolerant or have an inadequate response to the drugs. Prior to this study, no controlled trials had examined whether patients who don't respond to one TNF-a inhibitor might respond to another.

More information

The Arthritis Foundation has more about rheumatoid arthritis.

-- Robert Preidt

SOURCE: The Lancet, news release, June 28, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Respiratory Rally a Promising Practice in the Fight Against Chronic Disease
2. Promising Therapy for Prostate Cancer
3. Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer
4. AGH Joins Select Group of Medical Centers in Study of Promising New Technology for Treatment of Heart Failure
5. 17 of Americas Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences
6. CORRECTION: Viral Genetics Pursues Promising New Therapy for Lyme Disease With Grant from Time for Lyme, Inc.
7. Mayo Clinic Researchers Say Triple Drug Combination is Promising Option to Treat Metastatic HER2+ Breast Cancer
8. Triple drug combination is promising option to treat metastatic HER2+ breast cancer
9. Aleres Dr. Gordon Norman Highlights Challenges and Promising Solutions to U.S. Healthcare System to International Health Insurance Executives
10. New drug shows promising results for psoriatic arthritis
11. Will Obamas Stem Cell Announcement Doom Promising Adult Stem Cell Research?
Post Your Comments:
Related Image:
New Drug Promising Against Rheumatoid Arthritis
(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, Bohrer Brady, ... of Connecticut on behalf of a home health care worker who provided companionship services ... home health care workers employed by Humana, Inc., Humana at Home, Inc., and SeniorBridge ...
(Date:11/25/2015)... Canadian, OK (PRWEB) , ... November 25, 2015 , ... ... and International training center for the Narconon network, announced the release of a new ... Since 1966 the Narconon organization has been working with drug- and alcohol-addicted individuals with ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... double board certified facial plastic surgeon specializing in both surgical and non-surgical treatments, ... The Skin Spa at Hobgood Facial Plastic Surgery. , Highly trained and ...
(Date:11/25/2015)... ... ... Today, Mothers Against Drunk Driving (MADD) learned that the number ... first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol impaired ... Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in 2014. ...
(Date:11/25/2015)... ... ... An unlikely combination of recycled plastic shopping bags in ... to have a more dignified and comfortable night’s sleep. , Residents of Friendship ... bags into sleeping mats for the homeless. The project, according to Jeannette ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... - Will Also Offer Point -of- ... --> - Will Also Offer Point ... --> - Will Also Offer ... (CME) Elsevier , a world-leading provider of ... diagnostic imaging textbooks and decision support tools, as well as prominent ...
(Date:11/24/2015)... , November 25, 2015 ... due to repeated failure of IVF cycles. After failure ... was totally dejected and had lost all hopes that she would be able ... Indian miracle child conceived after failure of over 15 ... abroad (UK) before they decided to take one last attempt with ...
(Date:11/24/2015)... Nov. 24, 2015  Array BioPharma Inc. (Nasdaq: ... Executive Officer, Ron Squarer , will present ... New York.  The public is welcome to participate ... Array BioPharma website.Event:Piper Jaffray Annual Healthcare ConferencePresenter:  , ... 2, 2015Time:1:30 p.m. Eastern Time Webcast: ...
Breaking Medicine Technology: