Navigation Links
New Drug May Help Fight Certain Advanced Lung Cancers
Date:6/3/2013

MONDAY, June 3 (HealthDay News) -- For patients struggling with a common and deadly form of lung cancer, adding the drug ganetespib to a standard chemotherapy drug may boost survival, new research suggests.

The finding centers on a class of medications known as heat shock protein 90 (Hsp90) inhibitors, and it's the first time in more than 10 years that researchers have uncovered a better way to treat this group of patients.

The findings were slated for presentation Monday in Chicago at the annual meeting of the American Society of Clinical Oncology.

"This is the first randomized study to demonstrate therapeutic benefit with a heat shock protein inhibitor in patients with cancer," study lead author Dr. Suresh Ramalingam, a professor of medical oncology at the Winship Cancer Institute of Emory University, in Atlanta, said in an ASCO news release.

The study focused on patients with a form of non-small cell lung cancer known as lung adenocarcinoma.

"We hope that the ongoing study will confirm our findings, as patients with this common form and stage of lung cancer urgently need more effective treatments," Ramalingam said.

The researchers said adenocarcinoma is the most common form of lung cancer. In the United States, it accounts for roughly 45 percent of the 170,000 non-small cell lung cancers diagnosed annually.

Ganetespib works by halting the function of newly established proteins that are involved in promoting the lung tumor's growth.

The new study was funded by drug maker Synta Pharmaceuticals and involved more than 250 patients, all of whom had tried standard treatments to no avail.

Half the patients were treated with the standard chemotherapy drug docetaxel, while the other half were given ganetespib in tandem with docetaxel.

Patients in the ganetespib group had longer average survival rates relative to those in the docetaxel-only group -- 9.8 months versus 7.4 months, respectively. Patients with advanced cancer that had been diagnosed at least six months prior to treatment saw a 67 percent boost in survival compared to similar patients who didn't get the new drug.

The researchers noted that prior trials on Hsp90 inhibitor drugs haven't panned out because side effects for patients were so dire. They said this is the first trial in which the drug has proven both safe and potentially effective.

Experts who weren't involved in the research were encouraged by the results.

"Ganetespib, in combination with docetaxel, shows promising early results in lung adenocarcinoma," Dr. Marjorie Zauderer, an ASCO spokeswoman and lung cancer expert, said in the news release. "We're hopeful about the outcome of an ongoing study, which could help more patients with this form of advanced lung cancer access this promising drug."

Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in New York City, agreed.

"Finally there is a drug that can be offered to patients with advanced lung cancer, along with another drug," Horovitz said. "Ganetespib appears to increase overall survival independent of genetic markers. Since so many lung cancers are diagnosed at a late stage, this may help many patients."

Findings presented at medical meetings typically are considered preliminary until published in a peer-reviewed journal.

More information

For more on lung cancer, head to the U.S. National Cancer Institute.

-- Alan Mozes

SOURCES: June 3, 2013, news release, American Society of Clinical Oncology; Len Horovitz, M.D, pulmonary specialist, Lenox Hill Hospital, New York City


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. National Camp Series (NCS) Associate Chris Husby Joins Kicking For The Dream’s Effort to Fight Ovarian Cancer
2. Stress Kills (Literally), But It’s Not Too Late to Fight Back
3. Researchers discover new weapon in fight against cervical cancer
4. Immune system to fight brain tumors
5. Sport-Social for Autism Fights to Win Contest
6. Sailormen Inc. Popeyes Raises More than $670,000 to Help Fight Muscle Disease
7. Retired NFL Kicker and National Camp Series (NCS) Founder Michael Husted Joins Kicking For The Dream’s Effort to Fight Ovarian Cancer
8. Austin Sports Medicine Presents: Five Tips for Fighting Childhood Obesity
9. Common Supplement May Help Patients Fight Heart Failure
10. Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
11. When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug May Help Fight Certain Advanced Lung Cancers
(Date:5/2/2016)... ... ... “Engineering Bubbles,” an oil painting submitted by Canadian radiology resident Dr. Kari ... the Annual Meeting in Los Angeles. The first annual art forum was a platform ... attendees. , “Through art I hope to educate people about radiology and its ...
(Date:5/2/2016)... DC (PRWEB) , ... May 02, 2016 , ... ... Results and Data Book for the 2016 Main Residency Match® (“the Match”), the ... positions in United States teaching institutions. A record-high 30,750 positions were placed in ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Philip Shindler, dentist in ... day treatments. In the past, many necessary dental treatments could require multiple appointments to ... anesthetic shots and extra chair time. Not only could this be inconvenient, but it ...
(Date:5/2/2016)... ... May 02, 2016 , ... East Los Angeles dentist , Dr. ... visit Dr. Assili to receive any dental extraction treatment for $40 off the regular ... 30, 2016. With the lower price, patients can more easily afford extractions to eliminate ...
(Date:5/2/2016)... NY (PRWEB) , ... May 02, 2016 , ... This ... reopened for its 2016 guest season which runs through October. Omega is offering a ... . , “There has never been such widespread interest in or need ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... Leading Economies with Fastest Real GDP Annual Percentage Change, 2015  ... 7.8 India 7.3, , Source: IMF and TechSci Research   ... Brazil , Russia , India ... , registered the fastest GDP growth during the first decade of the 21 ... in Brazil and Russia , along ...
(Date:5/2/2016)... LAWRENCEVILLE, N.J. , May 2, 2016 /PRNewswire/ ... drug development company, today announced data from the ... dose escalating clinical trial (the OVATION Study) combining ... of care for the treatment of newly-diagnosed patients ... chemotherapy followed by interval debulking surgery.  In the ...
(Date:4/29/2016)... , April 29, 2016 ... H1 2016" market research report that provides an ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
Breaking Medicine Technology: