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New Drug May Help Combat Alzheimer's
Date:8/6/2008

ia, such as primary progressive aphasia (PPA), elevated levels of TNF interfere with brain function, and could respond to treatment with perispinal etanercept. Rapid improvement in impaired speech, beginning within minutes, seems to be a unique effect of perispinal etanercept, and illustrates the existence of rapidly reversible TNF-dependent brain mechanisms in Alzheimer's disease and primary progressive aphasia.

Rapid improvement in cognition in patients with Alzheimer's following perispinal etanercept has also been recently reported (3,4,5). These rapid effects are thought to be due to TNF's novel role as a gliotransmitter regulating synaptic transmission (communication between brain cells), a physiologic function of TNF only recently recognized.

These new articles provide further evidence, in addition to accumulating genetic, epidemiologic, and basic science data (reviewed in references 3, 4, and 5), that excess TNF is a therapeutic target in Alzheimer's disease and related forms of dementia, and provide an exciting new direction for research.

Further information, including links to the published articles and videos of actual patient response, are available on the Web site of the Institute for Neurological Research(INR®), a private medical group, inc., at www.nrimed.com. Perispinal administration of etanercept for the treatment of Alzheimer's disease and selected additional neurological disorders is a patented invention of the INR; protected by U.S. patent 7,214,658, assigned to TACT IP, LLC and licensed to the INR, and additional issued and pending U.S. and international patents. For a further description of the attached video, please see the Medscape J Med. 2008; 10(6): 135. Physician training is available; please contact the INR for further information.

The new articles are open access, and available directly at the following links:

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