Navigation Links
New Drug Helps Relieve Gout
Date:9/3/2008

Pegloticase normalized uric acid levels within 6 hours for participants in phase II trial

WEDNESDAY, Sept. 3 (HealthDay News) -- An experimental gout drug called pegloticase lowered levels of uric acid in the blood to target levels within a few hours in most patients.

That's the conclusion of a study by researchers at Duke University Medical Center and Savient Pharmaceuticals, the company that's developing the drug.

The phase II clinical trial included 41 patients randomly selected to receive either four or eight milligrams of pegloticase every two weeks, or eight or 12 milligrams every four weeks, for a 12- or 14-week period. The treatment is an infusion that takes about two hours.

Pegloticase normalized uric acid levels within six hours for participants in all dosage groups, and those levels were sustained throughout the treatment period in the two groups at the higher dosage levels. The most effective dose was found to be eight milligrams every two weeks, the study found.

During treatment, 88 percent of the patients experienced gout flares and some also experienced mild to moderate side effects, including reactions to the infusion and joint pain.

"The generally accepted goal of therapy is to reduce serum urate concentrations to less than 6 milligrams per deciliter, and we found that pegloticase can do that very, very quickly," study lead author Dr. John Sundy, a rheumatologist at Duke, said in a university news release.

"We were delighted to see this response, because all of the patients in our trial had already tried all the existing treatments for gout, and nothing was helping them," said Sundy, who added that more studies need to be conducted to confirm and expand the findings.

The findings were published online and were to be in the September issue of the journal Arthritis & Rheumatism. Results of a phase III study of pegloticase were expected to be presented in October at the annual meeting of the American College of Rheumatology, in San Francisco.

More information

The American Academy of Family Physicians has more about gout.



-- Robert Preidt



Duke University, news release, Sept. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
2. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
3. Radiation and drug combo helps boost efficacy of lung cancer treatment
4. Childs Flu Shot Helps Whole Family
5. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
6. Generic prostate drug helps find high-risk cancers early
7. Tamoxifen Helps Treat Bipolar Disorder
8. Imaging Software Helps Track, Treat Injured Brains
9. GPS-like technology helps pinpoint best methods for moving injured players
10. New Website Helps Women Be Fit, Sexy and in Control!
11. Brain Defect Helps Drive Fragile X Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... ... child abuse and neglect, and the struggles faced while hoping for a better ... of published author, Judy Von Bernewitz, who spent 13 years working with deprived/neglected ...
(Date:8/22/2017)... , ... August 22, 2017 , ... “Glimpses Of Light”: ... of the world. “Glimpses Of Light” is the creation of published author, J.M. Shepherd, ... in search of answers to life’s perplexing mysteries. , Shepherd shares, “Love is one ...
(Date:8/22/2017)... , ... August 22, 2017 , ... TopConsumerReviews.com recently gave ... fight Fatigue . , As the stress of modern life continually makes more ... pace. Constant use of artificial stimulants can trap people in vicious high/low cycles and ...
(Date:8/22/2017)... ... , ... Although Labor Day is not as popular for fireworks as New ... and numerous households celebrate the unofficial end of summer with backyard fireworks shows. While ... , Kris Zambo, owner of Dynamite Fireworks in Hammond, Indiana, provides 5 ...
(Date:8/21/2017)... Ca (PRWEB) , ... August 22, 2017 , ... ... industries, but not without risk to health and safety. By learning and implementing ... be eliminated. , In this webinar, attendees will gain a better understanding ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Calif. , Aug. 2, 2017 ... Continental Who,s Who as a Pinnacle Lifetime Professional ... the Key Account Manager at Turing Pharmaceuticals, AG. ... negotiations, troubleshooting and relationship building.                ... has more than 25 years of experience as ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/27/2017)... Holdings, Inc. (NYSE and SIX: ZBH) today reported financial results ... reported second quarter net sales of $1.954 billion, an ... an increase of 2.1% on a constant currency basis.  ... LDR Holding Corporation acquisition, second quarter 2017 revenues decreased ... on a constant currency basis. ...
Breaking Medicine Technology: