Navigation Links
New Drug Helps Relieve Gout
Date:9/3/2008

Pegloticase normalized uric acid levels within 6 hours for participants in phase II trial

WEDNESDAY, Sept. 3 (HealthDay News) -- An experimental gout drug called pegloticase lowered levels of uric acid in the blood to target levels within a few hours in most patients.

That's the conclusion of a study by researchers at Duke University Medical Center and Savient Pharmaceuticals, the company that's developing the drug.

The phase II clinical trial included 41 patients randomly selected to receive either four or eight milligrams of pegloticase every two weeks, or eight or 12 milligrams every four weeks, for a 12- or 14-week period. The treatment is an infusion that takes about two hours.

Pegloticase normalized uric acid levels within six hours for participants in all dosage groups, and those levels were sustained throughout the treatment period in the two groups at the higher dosage levels. The most effective dose was found to be eight milligrams every two weeks, the study found.

During treatment, 88 percent of the patients experienced gout flares and some also experienced mild to moderate side effects, including reactions to the infusion and joint pain.

"The generally accepted goal of therapy is to reduce serum urate concentrations to less than 6 milligrams per deciliter, and we found that pegloticase can do that very, very quickly," study lead author Dr. John Sundy, a rheumatologist at Duke, said in a university news release.

"We were delighted to see this response, because all of the patients in our trial had already tried all the existing treatments for gout, and nothing was helping them," said Sundy, who added that more studies need to be conducted to confirm and expand the findings.

The findings were published online and were to be in the September issue of the journal Arthritis & Rheumatism. Results of a phase III study of pegloticase were expected to be presented in October at the annual meeting of the American College of Rheumatology, in San Francisco.

More information

The American Academy of Family Physicians has more about gout.



-- Robert Preidt



Duke University, news release, Sept. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
2. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
3. Radiation and drug combo helps boost efficacy of lung cancer treatment
4. Childs Flu Shot Helps Whole Family
5. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
6. Generic prostate drug helps find high-risk cancers early
7. Tamoxifen Helps Treat Bipolar Disorder
8. Imaging Software Helps Track, Treat Injured Brains
9. GPS-like technology helps pinpoint best methods for moving injured players
10. New Website Helps Women Be Fit, Sexy and in Control!
11. Brain Defect Helps Drive Fragile X Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America proudly introduces the ... instant energy-saving solution for F32T8 fluorescent lamps on most instant-start and programmed-start electronic ... hour rated lamps utilize the existing electronic ballast, saving labor and maintenance costs. ...
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic Back ... joined the revolutionary endoscopic practice under Dr. Datta. Patel is a Board Certified ... The patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is unlike ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Texas Cord Blood ... to the labor and delivery team at Women’s Hospital at Renaissance in Edinburg for ... birth at the hospital and decide to donate. , “Women’s Hospital at Renaissance ...
(Date:4/28/2017)... ... April 28, 2017 , ... Early ... substantially improve drug safety and minimize the cost of development. In this webinar, ... inhibition using cell lines and for cardiac toxicity using induced pluripotent stem cells ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... Bill Howe ... industry in the coastal communities. After Tina Howe joined the team, the Bill Howe ... employees, honest services at affordable rates, and giving back to the San Diego community ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  CVS Pharmacy, the ... unveiled a new store design to enhance the ... healthier food, health-focused products and expanded beauty selections ... help customers discover new offerings. Together with its ... evolution of the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... 20, 2017  AbbVie (NYSE: ABBV), a global ... of chronic hepatitis C virus (HCV) infected patients ... and compensated cirrhosis (Child-Pugh A) achieved sustained virologic ... with its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). ... following 12 weeks of G/P treatment without ribavirin. ...
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
Breaking Medicine Technology: