Navigation Links
New Drug Fights Medication-Linked Bone Loss
Date:11/14/2007

Teriparatide may help asthma patients avoid fracture, researchers say

WEDNESDAY, Nov. 14 (HealthDay News) -- A new drug has proven superior to standard therapy at slowing bone loss caused by asthma treatment, researchers say.

Glucocorticoid medicines such as prednisone are often given to treat asthma, autoimmune disorders, skin allergies and other conditions, researchers note. But the drugs can also cause osteoporosis.

The new drug, an anabolic steroid called teriparatide, probably will be the preferable treatment "for patients who have particularly bad disease to start with or are on glucocorticoids for a long time," said Dr. Kenneth G. Saag, professor of medicine and epidemiology at the University of Alabama at Birmingham.

The study, which was funded by teriparatide's maker, Eli Lilly & Co., is published in the Nov. 15 issue of the New England Journal of Medicine.

One million Americans are taking glucocorticoids for one condition or another, Saag said, and many are at higher risk of fractures, because the medications weaken their bones. Current treatment for medication-linked osteoporosis centers on use of bisphosphonates, medications designed to prevent bone breakdown.

The 18-month trial included 428 men and women with drug-caused osteoporosis who had been taking glucocorticoids for at least three months. Half were assigned to take alendronate, a bisphosphonate, while the other half took teriparatide.

After three months, the increase in bone density at the lumbar (lower) spine was double for those taking teriparatide -- an average 7.2 percent rise versus 3.4 percent in the alendronate group. The teriparatide group also experienced fewer fractures of the vertebral bones compared with those on the bisphosphonate.

But teriparatide's much higher cost will limit its use, Saag said. "Use of therapy is driven by insurance as well as by appropriate bone density and fracture rate," he said. "We would like to be able to single out those patients whose minimal bone density puts them at higher risk for fracture," Saag said. "Those patients are the ones we want to target more aggressively."

That group would include 30 percent to 50 percent of those with drug-caused osteoporosis, he said. The U.S. Food and Drug Administration already has approved use of teriparatide for the condition.

The anabolic steroid is a better treatment, because bisphosphonates do not actually promote bone growth, added Dr. Robert R. Recker, professor of medicine at Creighton University and a member of the Osteoporosis Research Center there. Rather, they prevent bone destruction by natural processes such as apoptosis (natural cell death), he said

"There is a greater need for a bone-forming agent, one that interferes with the apoptosis of bone cells," Recker said. "The condition is not so much a low bone mass disease but a disease of bone cells that results in too much remodeling. Bisphosphonates lower remodeling. [Teriparatide] increases new bone formation."

But longer-term studies are still needed to assess teriparatide's effects over prolonged periods, Recker said.

"Not one study has gone long enough to see if you get more benefits by using it for a long time," he said. "It may be good for 24 months. That remains to be seen."

More information

There's more on medication-linked bone loss at the American College of Rheumatology.



SOURCES: Kenneth G. Saag, professor, medicine and epidemiology, University of Alabama at Birmingham; Robert R. Recker, M.D., professor, medicine, Creighton University, Omaha, Neb.; Nov. 15, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Guacamole: Fights Hunger, Cholesterol and Cancer
2. Two-Drug Combo Fights Brain Tumors
3. Connecticut Girl Fights Rare Neurological Disease
4. Experimental Drug Fights Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug Fights Medication-Linked Bone Loss
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
Breaking Medicine Technology: