Navigation Links
New Drug Fights Medication-Linked Bone Loss
Date:11/14/2007

Teriparatide may help asthma patients avoid fracture, researchers say

WEDNESDAY, Nov. 14 (HealthDay News) -- A new drug has proven superior to standard therapy at slowing bone loss caused by asthma treatment, researchers say.

Glucocorticoid medicines such as prednisone are often given to treat asthma, autoimmune disorders, skin allergies and other conditions, researchers note. But the drugs can also cause osteoporosis.

The new drug, an anabolic steroid called teriparatide, probably will be the preferable treatment "for patients who have particularly bad disease to start with or are on glucocorticoids for a long time," said Dr. Kenneth G. Saag, professor of medicine and epidemiology at the University of Alabama at Birmingham.

The study, which was funded by teriparatide's maker, Eli Lilly & Co., is published in the Nov. 15 issue of the New England Journal of Medicine.

One million Americans are taking glucocorticoids for one condition or another, Saag said, and many are at higher risk of fractures, because the medications weaken their bones. Current treatment for medication-linked osteoporosis centers on use of bisphosphonates, medications designed to prevent bone breakdown.

The 18-month trial included 428 men and women with drug-caused osteoporosis who had been taking glucocorticoids for at least three months. Half were assigned to take alendronate, a bisphosphonate, while the other half took teriparatide.

After three months, the increase in bone density at the lumbar (lower) spine was double for those taking teriparatide -- an average 7.2 percent rise versus 3.4 percent in the alendronate group. The teriparatide group also experienced fewer fractures of the vertebral bones compared with those on the bisphosphonate.

But teriparatide's much higher cost will limit its use, Saag said. "Use of therapy is driven by insurance as well as by appropriate bone density and fracture rate," he said. "We would like to be able to single out those patients whose minimal bone density puts them at higher risk for fracture," Saag said. "Those patients are the ones we want to target more aggressively."

That group would include 30 percent to 50 percent of those with drug-caused osteoporosis, he said. The U.S. Food and Drug Administration already has approved use of teriparatide for the condition.

The anabolic steroid is a better treatment, because bisphosphonates do not actually promote bone growth, added Dr. Robert R. Recker, professor of medicine at Creighton University and a member of the Osteoporosis Research Center there. Rather, they prevent bone destruction by natural processes such as apoptosis (natural cell death), he said

"There is a greater need for a bone-forming agent, one that interferes with the apoptosis of bone cells," Recker said. "The condition is not so much a low bone mass disease but a disease of bone cells that results in too much remodeling. Bisphosphonates lower remodeling. [Teriparatide] increases new bone formation."

But longer-term studies are still needed to assess teriparatide's effects over prolonged periods, Recker said.

"Not one study has gone long enough to see if you get more benefits by using it for a long time," he said. "It may be good for 24 months. That remains to be seen."

More information

There's more on medication-linked bone loss at the American College of Rheumatology.



SOURCES: Kenneth G. Saag, professor, medicine and epidemiology, University of Alabama at Birmingham; Robert R. Recker, M.D., professor, medicine, Creighton University, Omaha, Neb.; Nov. 15, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Guacamole: Fights Hunger, Cholesterol and Cancer
2. Two-Drug Combo Fights Brain Tumors
3. Connecticut Girl Fights Rare Neurological Disease
4. Experimental Drug Fights Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug Fights Medication-Linked Bone Loss
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
Breaking Medicine Technology: