Navigation Links
New Drug Fights Anthrax Toxin
Date:7/8/2009

Raxibacumab being stockpiled for possible anthrax attack, researcher says,,

WEDNESDAY, July 8 (HealthDay News) -- Scientists report that experiments in animals show that a new, monoclonal antibody drug might safely cure anthrax poisoning in humans.

Although antibiotics can kill the anthrax bacteria, they are not effective in killing the toxins produced by the bacteria. The new drug, raxibacumab, specifically targets those toxins once they enter the bloodstream. After an anthrax attack, people may not know they are infected until the toxins are circulating in their blood, and it may be too late for antibiotics alone to be effective, the researchers explained.

"This drug strengthens America's arsenal against bioterrorism that would work in the face of antibiotic-resistant anthrax bacterium," said lead researcher Sally Bolmer, senior vice president of development and regulatory affairs at Human Genome Sciences Inc., the company that developed raxibacumab.

The drug works differently than antibiotics, Bolmer noted. "It [also] acts more quickly than vaccines. So, it is complementary to both of those," she said.

"If we administered it at the time the animals were exposed to anthrax or even waited until their symptoms developed, we could improve survival in rabbits and monkeys," she said.

The same doses of the drug were given to humans and the drug was well-tolerated, Bolmer added.

The report is published in the July 9 issue of the New England Journal of Medicine.

In the study, researchers showed that a single dose of raxibacumab was an effective treatment for inhalation anthrax in both rabbits and monkeys.

The drug provided a significant survival benefit to animals showing signs of the disease. The animals were exposed to a dose of anthrax approximately 200 times the lethal dose, the researchers said.

In addition, raxibacumab was safe when given to human volunteers and could be used in a clinical setting in cases of life-threatening inhalation anthrax disease, Bolmer said.

Under a contract with U.S. Biomedical Advanced Research and Development Authority, the company has delivered 20,000 doses of raxibacumab to the U.S. Strategic National Stockpile for emergency use. Approval of the drug by the U.S. Food and Drug Administration is pending, Bolmer said.

Mingtao Zeng, an assistant professor in the department of microbiology and immunology at the University of Rochester Medical Center, said this study has provided solid data to support raxibacumab as a new candidate drug for biodefense and public health.

"The most encouraging finding is that raxibacumab appeared to be safe and well-tolerated, with reasonably high doses in the phase 1 human clinical trial, which had 333 healthy human volunteers," Zeng said. "I anticipate that raxibacumab can be used as a short-term prophylactic agent for protection against anthrax or as a therapeutic drug in combination with antibiotics for effective treatment of anthrax."

Dr. Gary Nabel, director of the Vaccine Research Center at the U.S. National Institute of Allergy and Infectious Diseases and author of an accompanying journal editorial, said the paper shows that the antibody can block infection in animals and similar levels of the drug can be safely given to people.

"It therefore satisfies the criteria of the animal rule, a regulatory guideline used to approve drugs for diseases that can't be tested for efficacy in humans," Nabel said.

This antibody provides a new tool to control anthrax infection and "if approved, could be stockpiled as a countermeasure against this potential public health threat," he said.

"This paradigm of drug approval for biodefense agents provides a new way to address such threats, though questions remain about how and when to use such drugs and how to incentivize industry to produce them," Nabel said.

More information

For more on anthrax, visit the U.S. Centers for Disease Control and Prevention .



SOURCES: Sally Bolmer, Ph.D., senior vice president, development and regulatory affairs, Human Genome Sciences Inc., Rockville, Md.; Mingtao Zeng, Ph.D., assistant professor, department of microbiology and immunology, University of Rochester Medical Center, Rochester, N.Y., Gary Nabel, M.D., Ph.D., director, Vaccine Research Center, U.S. National Institute of Allergy and Infectious Diseases, Bethesda, Md.; July 9, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Guacamole: Fights Hunger, Cholesterol and Cancer
2. Two-Drug Combo Fights Brain Tumors
3. Connecticut Girl Fights Rare Neurological Disease
4. Experimental Drug Fights Prostate Cancer
5. New Drug Fights Medication-Linked Bone Loss
6. MIT radar technology fights breast cancer
7. Drug fights cystic fibrosis
8. USAID Fights Neglected Tropical Diseases
9. Mothers & More Fights to End Invisimomibility
10. Dr. Lance H. Brown President-Elect of Dermatologic Society of Greater New York Fights Misconceptions About Sun Protection and Skin Care in Support of Skin Cancer Awareness Month - May
11. Fish diet to avoid fights
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug Fights Anthrax Toxin  
(Date:1/20/2017)... , ... January 20, 2017 , ... "TransFlare 4K Mystique ... inside of Final Cut Pro X," said Christina Austin - CEO of Pixel Film ... Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and light leak transitions have ...
(Date:1/20/2017)... ... ... Chocolate Biscuit”: a biographical account following a man who went on to support his country ... Ivey, born in Lynn Haven, Florida and at the age of 5, his family moved ... he joined the Navy and got married right out of boot camp. , He ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Journey to Christmas:” a beautiful and enchanting ... of published author, Kimberly Cordoves, a mother of three in Oklahoma City, and a devoted ... idea of writing a book has been in the back of my mind for years, ...
(Date:1/19/2017)... ... January 20, 2017 , ... Today, the Centers for ... in four of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who participate in ... APMs are an important part of the Administration’s effort to build a system that ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... With the cold weather here, many people ... Snow blowers are efficient when clearing large amounts of snow, but they can be dangerous ... the U.S. Consumer Product Safety Commission for the proper use of snow blowers:, ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 19, 2017 Shire ... that the U.S. Food and Drug Administration (FDA) has ... New Drug Application (NDA) for SHP465, a long-acting, triple-bead, ... a potential once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The ... around June 20, 2017, the designated Prescription Drug User ...
(Date:1/19/2017)... CAMBRIDGE, England , January 19, 2017 ... MedImmune and Otsuka in the Milner Therapeutics Consortium   ... academic scientists in Cambridge   ... Inc. (NYSE: PFE ) as a partner ... join the Consortium, which enables the efficient transfer of ...
(Date:1/19/2017)... January 19, 2017 While ... serious about reducing the FDA,s regulatory strictness as ... the medical drug industry, many of the leading ... clinical trials and development of advanced drug treatments ... with recent developments include:  Moleculin Biotech, Inc., (NASDAQ: ...
Breaking Medicine Technology: