Navigation Links
New Drug Being Tested for Pancreatic Cancer
Date:4/15/2009

Lab findings show potential for use alone or in combination, scientist says,,

WEDNESDAY, April 15 (HealthDay News) -- An experimental drug appeared to reduce pancreatic cancer growth in laboratory tests, according to researchers from the drug's maker, Amgen.

Called AMG 479, the drug is designed to inhibit the activity of insulin-like growth factors IGF-1 and IGF-2.

"We know that insulin-like growth factors play a role in cancer development, particularly in mediating cell survival," Pedro J. Beltran, a principal scientist in oncology research at Amgen, said in a news release from the American Association for Cancer Research. "This is the first drug that specifically targets the receptor for these growth factors without cross-reacting with the closely related insulin receptor."

Beltran and his fellow researchers found that AMG 479 bound to IGF-1R and blocked both IGF-1 and IGF-2 binding factors 1 and 2. The drug also completely inhibited ligand-induced activation in some growth factors, resulting in decreased pancreatic cell viability. The drug achieved an 80 percent inhibition rate of tumor growth and receptor expression, according to the researchers.

The findings appear in the current issue of Molecular Cancer Therapies.

"These data clearly show that AMG 479 is a clinical candidate for pancreatic cancer therapy, either alone or in combination with gemcitabine," Beltran said.

Gemcitabine is the only available treatment for pancreatic cancer, but the researchers said that it has yet to show a survival benefit.

AMG 479 is now being tested in nine separate phase II studies of various cancer types.

An estimated 200,000 people are diagnosed each year with pancreatic cancer, according to background information in the news release. Less than 4 percent live more than five years, it said, making pancreatic cancer one of the deadliest cancers.

More information

The American Cancer Society has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Amgen, news release, April 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Adult Well-Being Services Offers Valuable Resources for Caregivers
2. Don't Sacrifice Your Well-being in a Discount Destination
3. On Being a Scientist: A Guide to Responsible Conduct in Research, third edition
4. Many Americans Fear Being Diagnosed With Diabetes
5. Pitt vaccine to prevent colon cancer being tested in patients
6. Employee cardiovascular health relates to psychological well-being
7. Video: CLARITIN Partners with NASCAR Driver Carl Edwards to Educate Motorists on the Importance of Being Clear to Drive(SM)
8. Childrens Bedding Naturally Enhances Emotional Well-being
9. Nurse practitioners dont realize how much their prescribing is being influenced by drug marketing
10. Patients being discharged against medical advice
11. Patients Being Discharged Against Medical Advice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Drug Being Tested for Pancreatic Cancer
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: