Navigation Links
New Diabetes Drugs Have Different Advantages, Study Says

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Nov. 7 (HealthDay News) -- A head-to-head comparison of two new type 2 diabetes drugs produced mixed results.

In the study, liraglutide (Victoza) was somewhat better than the other drug, exenatide (Bydureon), in lowering blood sugar and weight, but Bydureon was associated with fewer side effects, researchers said.

Victoza is injected daily by patients and Bydureon is injected weekly. Both drugs are classified as "glucagon-like peptide-1 receptor agonists."

"These treatments are very powerful blood sugar-lowering agents that don't cause [too-low] blood sugar and are associated with weight loss," said lead researcher Dr. John Buse, a professor of medicine at the University of North Carolina at Chapel Hill. "That's a unique profile for a diabetes drug."

Patients can choose between them, Buse said. A lot depends on what the person is comfortable with. "You lay this all out for patients and help them decide," he said.

"The big frontier for patients with a chronic disease like diabetes is adherence to treatment: Patients developing a plan and sticking with a plan in managing their disease," Buse explained.

This study provides information for patients and doctors to use in coming up with a plan based on the effectiveness of the drugs, their side effects and how often they are injected, Buse noted.

The study, published online Nov. 7 in The Lancet, was funded by Eli Lilly and Amylin Pharmaceuticals, the makers of Bydureon.

For the study, researchers randomly assigned more than 900 patients to receive daily injections of Victoza, or weekly injections of Bydureon.

After 26 weeks, the investigators found that both drugs significantly reduced blood sugar levels. Significant drops were seen in 60 percent of the Victoza patients compared with 53 percent of those taking Bydureon.

Both drugs were associated with weight loss. Patients taking Victoza, however, lost about two pounds more than those taking Bydureon, the researchers noted.

Side effects occurred with both drugs. Nausea was the most common, reported by 21 percent of patients on Victoza compared with 9 percent among patients taking Bydureon. Diarrhea occurred in 13 percent of patients on Victoza and 6 percent of those on Bydureon, and vomiting was a problem for 11 percent of patients on Victoza compared with 4 percent on Bydureon.

Overall, 8 percent of patients dropped out of the study due to side effects, which the researchers pointed out declined for both drugs over time.

Another diabetes expert weighed in on the study medications.

"Both drugs appear to be about equivalent," said Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City.

"When these medications are used they are added to other medications that control blood sugar," he said. These include insulin and metformin, Mezitis noted.

The main difference between the drugs is daily versus weekly injections, he pointed out. "It may be easier to do it once a week, but you have to be more proficient injecting Bydureon," Mezitis said.

The mixing of the drug (Bydureon) and injecting using a larger needle may require some practice, he explained. With daily Victoza, injections are done with an smaller, thinner needle and some patients may find that better, Mezitis said.

"It depends on what the patient chooses," he said.

Mezitis noted these drugs cost anywhere from $200 to $400 a month and that many insurance companies cover them.

More information

To find out more about diabetes, visit the U.S. National Library of Medicine.

SOURCES: John Buse, M.D., professor of medicine, University of North Carolina, Chapel Hill; Spyros Mezitis, M.D., Ph.D., endocrinologist, Lenox Hill Hospital, New York City; Nov. 7, 2012, The Lancet, online

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. How a cancer drug leads to diabetes
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Common Plastics Chemical Might Boost Diabetes Risk
6. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Cellular pathway linked to diabetes, heart disease
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
Related Image:
New Diabetes Drugs Have Different Advantages, Study Says
(Date:11/25/2015)... ... 25, 2015 , ... In an ongoing Clinical Study conducted by an independent ... UV Angel is evaluating the efficacy of its product and its disinfection protocol. This ... beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical center ...
(Date:11/25/2015)... ... November 25, 2015 , ... In honor of Pulmonary ... individuals and groups responsible for advancing care for pulmonary hypertension (PH) patients and ... the public, will receive special recognition throughout 2016 as part of PHA’s 25th ...
(Date:11/25/2015)... ... ... Many people know of the common symptoms of low thyroid hormone (also known ... people who find their cholesterol levels and weight are creeping up are more likely ... don’t have any of the other symptoms. , Thyroid hormone plays a major role ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bunion ... in an early celebration of the early holiday shopping season. Starting Wednesday November ... (normally $33.95 ea). Black Friday promotional pricing is in addition to any automatic ...
(Date:11/24/2015)... ... November 24, 2015 , ... New patients who wish to seek ... dental implants at her Mississauga, ON practice. Dr. Williams has been providing ... of dental implants. , Missing teeth can lead to a variety of complications ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... -- The hope of bearing a child ... cycles. After failure of over 15 IVF cycles, Mrs. ... hopes that she would be able to conceive ever. But finally optimism prevailed as she ... of over 15 IVF cycles. India ... one last attempt with Gaudium IVF Center in New ...
(Date:11/24/2015)...  Thanks to a donor with a personal connection ... Sister Diane Grassilli Center for Women,s Health now offers ... San Francisco . Fred Ruhland ... a gift of $617,320 that allowed the Center to ... and Whole Breast Ultrasound. Tomosynthesis, three-dimensional (3-D) mammography for ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
Breaking Medicine Technology: