Navigation Links
New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada
Date:5/30/2011

An enzyme associated with extensive antibiotic resistance called New Delhi metallo--lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a case report in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj110477.pdf. The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment.

NDM-1 has spread because of worldwide travel, medical tourism and its ability to transfer between bacteria.

In one of the cases in this report, the patient had not travelled outside southwestern Ontario in over a decade, and no source could be identified for the organism. In the other case, the patient had been hospitalized in India for a medical procedure and acquired the organism there.

"These two scenarios show that local acquisition of an organism producing NDM-1 has already occurred in Ontario, Canada, that blaNDM-1 has been found in bacterial species other than [Escherichia coli] and [Klebsiella pneumoniae], that treatment options are limited for infections with NDM-1-producing organisms, and that the detection of NDM-1-producing organisms by a laboratory can be difficult," writes Dr. Susan Poutanen, Mount Sinai Hospital and University Health Network, with coauthors.

In the case of the patient who had not travelled, the authors note: "To the best of our knowledge, this is the first reported instance in which an NDM-1-producing organism was locally acquired in Canada."

In cases where patients are infected with NDM-1, extensive infection control precautions must be taken, including isolation in single rooms and enhanced cleaning.

"European guidelines recommend even more precautionary approaches to protecting patients admitted to hospital and suggest that all hospitals should have preparedness plans in place," state the authors.

Laboratory detection of the pathogen is also difficult, and labs should adopt different screening procedures.


'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Related medicine news :

1. Delhi air quality regulations improve respiratory health
2. Enzyme may drive breast cancer growth
3. Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
4. The TET1 enzyme steers us through fetal development and fights cancer
5. Investigators discover enzyme essential for healthy lung development
6. Newly discovered role for enzyme in neurodegenerative diseases
7. Enzyme helps prepare lung tissue for metastatic development
8. Heart Enzymes May Predict Outcome After Bypass Surgery
9. Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
10. Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
11. Chaperone enzyme provides new target for cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... 09, 2016 , ... Dr. Rassouli, cosmetic dentist in Orange County , ... most popular cosmetic procedures in dentistry today, but the cost often leads to patients ... risk of teeth whitening-related damage. For a limited time, Dr. Rassouli is offering this ...
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/8/2016)... ... ... CURE Media Group , the nation’s leading digital and print media enterprise ... , which will annually honor individuals making heroic contributions in the field of multiple ... Awards nomination process is officially open through February 17 for patients, caregivers and ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving with flowers, ... that they are loved. This year, for more than 5.6 million Americans suffering with ... won't be enough to remind them of the lives they’ve led and the people they’ve ...
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, serving ... program, has teamed up with Citizens Opposed to Domestic Abuse in support of its ... support all those victimized by the fear of violence in their own homes, donations ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... Inc. (NASDAQ: MSON ), an international surgical ... therapeutic ultrasonic products for spine surgery, skull-based surgery, ... other surgical applications, today announced financial results for ... fiscal year 2016 ended December 31, 2015. ... Highlights for the second quarter and first half ...
(Date:2/9/2016)... 2016 QGEN ; ... Abschluss eines Kooperationsvertrags mit 10x Genomics für ... den Bereichen Next-Generation-Sequencing (NGS), Single-Cell-Biology und Bioinformatik ... Prime Standard: QIA) gab heute den Abschluss ... Entwicklung und Förderung umfassender Lösungen in den ...
(Date:2/9/2016)... --  AllCare Plus Pharmacy announced today that it ... ® for Home Care Accreditation by ... Seal of Approval ® is a symbol of ... and effective care.  --> ... on-site survey in January 2016. The survey reflected compliance ...
Breaking Medicine Technology: