Navigation Links
New Data Supports Link Between Diabetes Drugs, Fractures

By Amanda Gardner
HealthDay Reporter

THURSDAY, July 29 (HealthDay News) -- New research finds that two widely prescribed diabetes drugs may raise the risk of broken bones in postmenopausal women with type 2 diabetes.

There was also a fracture risk seen among men who had been prescribed either Avandia or Actos plus a loop diuretic.

This isn't the first time such an association has been seen, raising doubts as to whether these drugs, which belong to the class of medications known as thiazolidinediones (TZDs), should be the first choice for treating type 2 diabetes.

"This raises the question of whether this class of drugs is best for patients. There are a lot of other great drugs you can use in diabetes, the best of which is to give patients insulin, which has no real side effects and has been used for 80 years," observed Steve Hammes, chief of endocrinology at the University of Rochester Medical Center. "It's more and more clear that, as a first-line agent, TZDs are probably not a good idea."

"This has been my worst worry for the longest time," added Dr. Mary Ann Banerji, director of the Diabetes Treatment Center at the State University of New York (SUNY) Downstate Medical Center in New York City. "Also, what about loop diuretics? We use all of these things, and the issue we should really be thinking through is what about other drugs we can use? What's the risk benefit?"

The findings may skew physicians away from both drugs, but especially Avandia, said Hammes.

Earlier this summer, a U.S. Food and Drug Administration advisory committee dealt rosiglitazone (Avandia) a blow when it concluded that Avandia raises the risk of heart attack and should only stay on the market with tightened controls.

Pioglitazone (Actos), on the other hand, has not been associated with an increased cardiac risk.

But the fracture risk in both drugs has been seen before and is already included in the labeling for the medications.

"I think there's enough data to put into question whether to use Avandia," Hammes said. "Most physicians are going to shy away from it and, in our clinic, we shy away it and if you're going to put someone on a TZD, you're going to put them on Actos."

These researchers analyzed data from an earlier observational study of diabetes patients, some of whom were taking TZDs.

Women over 50 who had broken bones were 71 percent more likely to have been prescribed a TZD.

In men, the increased risk (more than triple) was seen among those taking both TZDs and loop diuretics, but not in just one or the other.

And in both genders, the risk went up the longer a person was on the medication, which, according to Banerji, poses a particular problem.

"People have diabetes for many years not a short period of time. You can't put patients on these for a long period of time," she said. "We have to be very careful about prescribing TZDs at all and need to wait for the new class of TZDs that understands the [disease] process enough to hit the right target and not all these unanticipated targets."

But Hammes did point out that the study, which will appear in the October issue of the Journal of Clinical Endocrinology & Metabolism, did have some limitations. It was not, for instance, a randomized controlled study nor was the original study the data came from designed to look at this question.

The authors, from the University of Michigan and other institutions, called for larger, randomized trials.

More information

The U.S. National Library of Medicine has more on thiazolidinediones.

SOURCES: Mary Ann Banerji, M.D., professor, medicine, and director, diabetes treatment center, State University of New York Downstate Medical Center, New York City; Steve Hammes, M.D., Ph.D., chief, endocrinology, University of Rochester Medical Center, Rochester, N.Y.; October 2010, Journal of Clinical Endocrinology & Metabolism

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NASBE Supports First Lady Michelle Obama in Fight Against Childhood Obesity
2. Study supports alternative anti-seizure medication following acute brain injury
3. Minnesota Chiropractic Association Supports Lawsuit Against BCBSA
4. JPMA Supports CPSC Chairman Tenenbaum's Continued Safety Efforts
5. AT&T Foundations $50,000 Donation to National Health Foundation Supports Teen Pregnancy Prevention Program
6. reco jeans Supports Children With Rare Diseases
7. ChildCare Education Institute Supports the First Ladys Efforts to Reduce Childhood Obesity
8. WellNet Supports HPM Institute Director in Calling for More Active Enterprise Involvement in Managing Healthcare Quality and Costs
9. James Scott Farrin Supports Radiothon for Duke Children's Hospital
10. MARC Coalition Supports Medicare Secondary Payer Enhancement Act (MSPEA)/H.R. 4796
11. Hot Tub Company Helps Swimmers Thaw and Supports Special Olympics
Post Your Comments:
Related Image:
New Data Supports Link Between Diabetes Drugs, Fractures
(Date:11/27/2015)... ... 2015 , ... According to an article published November 13th on ... Washington D.C. revolved around the fact that proper dental care, both at-home and in ... link between periodontal disease (more commonly referred to as gum disease) and diabetes. According ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article published ... that they are handling security in light of the recent terrorist attacks in Paris, ... attempt to stop an attack from reaching U.S. soil. Especially around special events that ...
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has ... it. Surviving Mesothelioma has just posted the findings on the website. Click here ... the cases of 136 mesothelioma patients who were treated with chemotherapy followed by EPP ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When ... said an inventor from Hillside, N.J. "Many people catch diseases simply from sitting ... individuals will always be protected from germs." , He developed the patent-pending QUDRATECS ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... 27th edition of USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, ... The digital component is distributed nationally, through a vast social media strategy and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 Research and ... "Asia Pacific Cardiac Pacemaker Market Outlook to 2019 - ... Drive the Demand " report to their offering. ... --> Boston scientific and others. ... global players including Medtronic, Biotronik, Boston ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
Breaking Medicine Technology: