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New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V)
Date:12/7/2009

cember 6, 5:00 pm - 6:00 pm; Hall D, Level 2 (Abstract 2.228) D. Hebert(1), C. Helmstaedter(2), A. M. Kanner(3), J. Isojarvi(1), A. Eggert(4), P. Doty(1) (1)SCHWARZ BIOSCIENCES (a member of the UCB Group), Raleigh, North Carolina ; (2)Bonn University Hospital, Bonn, Germany; (3)Rush University Medical Center, Chicago, Illinois; (4)UCB, Inc., Atlanta, GA

Abstract: Effect of the New Anticonvulsant Drug Lacosamide on Persistent Na+- Current and Firing Behavior of Hippocampal Pyramidal Cells

This animal study examined the neurological impact of lacosamide on persistent sodium currents (INa,P) in the brain cells that regulate excitation - hippocampal CA1 pyramidal neurons. Findings suggest that lacosamide blocks persistent sodium currents in a manner that differs from that of carbamazepine, which acts on the sodium channel in a manner shared by traditional sodium channel agents.

  • Intact hippocampal CA1 neurons of mice were monitored for sodium current activity.
  • Lacosamide was shown to block INa,P in a dose-dependent manner (IC50 = 81 micrometers) and at a concentration range that is close to the mean plasma concentration (9.35 micrograms/milliliter; ~38 micrograms) observed in patients after 12 weeks of treatment with lacosamide 400 mg/day.
  • In addition, lacosamide was not shown to affect the voltage-dependence of activation of INa,P; this preferential action is in contrast to carbamazepine, for which a slight but significant hyperpolarizing shift of the voltage-dependence of activation has been observed.

Poster Session 2, Sunday, December 6, 4:00 pm - 5:00 pm; Hall D, Level 2 (Abstract 2.203) Mischa Uebachs(1), Thoralf Opitz(1), Thomas Stoehr(2), Isabelle Niespodziany(3), Christian Wolff(3), Heinz Beck(1)(1)University of Bonn, Dept. of Epileptology, Bonn, Germany; (2)bitop AG Stockumer Str. 28 58453 Witten, Germa
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