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New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V)
Date:12/7/2009

s who experienced a 50 or 75 percent or greater reduction in seizures compared to baseline.
  • The median percent reduction in seizure frequency for the first 3 months of treatment was 40.8 percent, 45.2 percent, 46.5 percent, 48.2 percent, 48.3 percent, and 46.5 percent for the 6, 12, 18, 24, 30, and 36 month cohort, respectively.
  • The median percent reduction for the last 3 months of treatment was 40.7 percent, 51.3 percent, 58.3 percent, 65.9 percent, 69.8 percent, and 59.7 percent for each cohort, respectively.
  • Responder rates were also sustained over time in each cohort:
    • Forty-one percent to 48 percent of patients reported a 50 percent or greater reduction in seizures during the first 3 months of treatment, compared with 42 percent to 70 percent for the last 3 months of treatment.
    • Seventeen percent to 24 percent of patients reported a 75 percent or greater reduction in seizures during the first 3 months of treatment, compared with 22 percent to 42 percent for the last 3 months.

Poster Session 2, Sunday, December 6, 5:00 pm - 6:00 pm, Hall D, Level 2 (Abstract 2.227) Elinor Ben-Menachem(1), Jacqueline French(2), Jouko Isojarvi(3), David Hebert(3), Pamela Doty(3) (1)Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden; (2)NYU Comprehensive Epilepsy Center, New York, New York; (3)SCHWARZ BIOSCIENCES (a member of the UCB Group), Raleigh, North Carolina

Abstract: Long-term Safety and Tolerability of Lacosamide for Partial-Onset Seizures: An Interim Evaluation of Patients Exposed to Lacosamide in Double-Blind and Open-Label Trials

This analysis of 1,327 patients exposed to lacosamide during double-blind or open-label extension trials demonstrated that the incidence of adverse events, as well as vital signs and clinical laboratory and ECG findings, among patients taking lacosamide for a median durati
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