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New Data Published in Immunobiology Describe Mode of Action of BiTE Antibody MT110
Date:1/28/2009

Study shows that very low amounts of Micromet's EpCAM-targeting BiTE antibody trigger the death of cancer cells

BETHESDA, Md., Jan. 28 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced publication of new data in the peer-reviewed journal Immunobiology describing in detail the mode of action of BiTE antibody MT110. MT110 is a T cell-engaging antibody that targets EpCAM, which is expressed with high frequency on most human adenocarcinoma.

Data from the new publication(1) demonstrate that when T cells are connected to cancer cells by MT110, they deliver two kinds of toxic proteins into cancer cells. One toxic protein, perforin, forms holes in the cancer cell's outer membrane. The second kind of protein, granzymes, is a family of proteolytic enzymes that triggers the self-destruction of the cancer cell, a process called programmed cell death or apoptosis. Very low amounts of MT110 were also found to increase the level of toxic proteins in T cells during cancer cell lysis, which is necessary for BiTE antibody-activated T cells to adopt a serial cancer cell-killing mode during which these toxic proteins are steadily consumed.

"Our new data explain the high anti-tumor activity of MT110 that we have seen in preclinical models, and that we have also observed with BiTE antibody blinatumomab in phase 1 and 2 clinical trials," commented Micromet's Chief Scientific Officer Dr. Patrick A. Baeuerle. "The mechanism of action of MT110 described in this study is expected to be identical for BiTE antibodies targeting other surface targets, and shows that this new class of antibody therapeutics has the potential to fully harness the power of T cells, the bo
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SOURCE Micromet, Inc.
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