Navigation Links
New Data Published in Immunobiology Describe Mode of Action of BiTE Antibody MT110
Date:1/28/2009

Study shows that very low amounts of Micromet's EpCAM-targeting BiTE antibody trigger the death of cancer cells

BETHESDA, Md., Jan. 28 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced publication of new data in the peer-reviewed journal Immunobiology describing in detail the mode of action of BiTE antibody MT110. MT110 is a T cell-engaging antibody that targets EpCAM, which is expressed with high frequency on most human adenocarcinoma.

Data from the new publication(1) demonstrate that when T cells are connected to cancer cells by MT110, they deliver two kinds of toxic proteins into cancer cells. One toxic protein, perforin, forms holes in the cancer cell's outer membrane. The second kind of protein, granzymes, is a family of proteolytic enzymes that triggers the self-destruction of the cancer cell, a process called programmed cell death or apoptosis. Very low amounts of MT110 were also found to increase the level of toxic proteins in T cells during cancer cell lysis, which is necessary for BiTE antibody-activated T cells to adopt a serial cancer cell-killing mode during which these toxic proteins are steadily consumed.

"Our new data explain the high anti-tumor activity of MT110 that we have seen in preclinical models, and that we have also observed with BiTE antibody blinatumomab in phase 1 and 2 clinical trials," commented Micromet's Chief Scientific Officer Dr. Patrick A. Baeuerle. "The mechanism of action of MT110 described in this study is expected to be identical for BiTE antibodies targeting other surface targets, and shows that this new class of antibody therapeutics has the potential to fully harness the power of T cells, the bo
'/>"/>

SOURCE Micromet, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Published reports inaccurate concerning alcohol consumption during pregnancy
2. Pexiganan Phase 3 Clinical Trials Results Published in December Issue of CID
3. New Guidebook Published for Improving B2B Sales Results in 90 Days or Less Through Kaizen Events
4. Arena Pharmaceuticals Announces Lorcaserin Phase 2b Clinical Trial Results Published in Obesity
5. New Requirements of EU Medical Device Directive Need Immediate Action, Nerac Analysts Urge in Newly Published White Paper
6. Data Published in Nature Medicine Highlights Ability of Peregrine Pharmaceuticals Bavituximab to Cure Lethal Virus Infections
7. First Study of War-Related Mental Disorders Among Iraqis 10 Years Post-Gulf War Published by Researchers at Wayne State University and Basrah University, Iraq
8. Long-Term Results of VisionCares Implantable Telescope for End-Stage Macular Degeneration Published in the American Journal of Ophthalmology
9. Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration
10. Enbrel(R) (etanercept) Is the First Biologic With Published Efficacy and Safety Data for up to a Decade of Continuous Use for the Treatment of Moderate to Severe Rheumatoid Arthritis
11. International Implementation of Breast Health Guidelines for Developing Countries Published by Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... September 19, 2014 Lipitor lawsuits ( ... some patients to develop Type 2 diabetes continue to ... in U.S. District Court, District of South Carolina, Bernstein ... on September 12, 2014, discovery is underway and moving ... noted that Pfizer, Inc., the manufacturer of Lipitor, has ...
(Date:9/19/2014)... In partnership with Raw Beauty NYC, OC healthcare ... project’s social media efforts. StudioPMG is honored to be a ... of beauty as it applies to disabled women. , ... Baer and Vanessa Silberman, who wanted to create a photo ... Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen later joined ...
(Date:9/19/2014)... campus of Mayo Clinic have discovered a defect in ... overproduction of toxic protein in the brains of ... communication between neurons both significant contributors to this ... issue of Neuron , offers the ... rejuvenate or rescue this pathway," says the study,s lead ...
(Date:9/19/2014)... 2014 (HealthDay News) -- More states are passing legislation ... to use for any child having a severe allergic ... "anaphylaxis," an allergic reaction that can lead to throat ... and even death. In people with severe ... nuts, insect venom or certain drugs, anaphylaxis can occur ...
(Date:9/19/2014)... difficult to study with X-ray crystallography, not least because ... crystallize, but also because their very nature means they ... structure can be obtained it is often of low ... domains that sometimes create more puzzles than they solve. ... D70, 2241-2255; doi: 10.1107/S1399004714016496 ] , Now, Gunnar ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 3Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:Mayo researchers reveal pathway that contributes to Alzheimer's disease 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 3Health News:A refined approach to proteins at low resolution 2Health News:A refined approach to proteins at low resolution 3
... soon connect every nook and corner of its vast ... social services to people, especially those living in far-flung ... of EDUSAT is being expanded across the country while ... the Indian Space Research Organisation (ISRO)," said S. Krishnamurthy, ...
... taken one more step towards a successful womb transplant. // ... wombs removed and then reconnected, Swedish scientists say. ... transplant in the sheep - where the same womb is ... that half the sheep in the study developed fatal complications ...
... Haryana government Tuesday proposed a medical university in the state ... ,Addressing the silver jubilee celebrations of the Government Dental ... Hooda said that setting up a medical university would help ... ,Hooda said that paucity of funds would ...
... researchers, children who report in with a head injury are twice ... //with children who sprain their ankle or wrist, instead. , ... which was published in the journal Pediatrics: “They were almost twice ... kids who had a sprained ankle or wrist." , ...
... Seventy percent of pediatricians rely on patients' family members ... a study by Johns Hopkins School of Medicine, the ... author Dennis Kuo, a general pediatrics fellow at Johns ... from the American Academy of Pediatrics and found that ...
... risk of breast cancer if they eat red meat, one more study ... of red meat had a 56% increased risk compared with those who ... meat, such as bacon, sausages, ham or pies, had a 64% greater ... University of Leeds study features in the British Journal of Cancer. ...
Cached Medicine News:Health News:Satellites Set to Play Good Samaritans in India 2Health News:Satellites Set to Play Good Samaritans in India 3Health News:Womb Transplant Pregnancy Success 2Health News:When ‘Humpty Dumpty’ Falls Aga 2Health News:Red Meat Increases Breast Cancer Risk 2
(Date:9/19/2014)... Research and Markets ... of the "Global Gynecological Devices Market ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... wide categories based on their operations. These ... different gynecological conditions that affect the female ...
(Date:9/19/2014)... TRIANGLE PARK, N.C. , Sept. 19, 2014 ... focused on cloud-based drug design and development, partnering ... The company,s mission is to design new drugs ... 1 and 2 partners to further their development. ... its portfolio investments. To support this business model, ...
(Date:9/19/2014)... , Sept. 19, 2014 The American Association ... Medical Design and Manufacturing has joined the AAHomecare Corporate ... Harvey Diamond have been actively involved in ... as it has quickly grown into a major global ... like Drive allows AAHomecare to increase efforts on behalf ...
Breaking Medicine Technology:Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2
... Inc. (NASDAQ: DCTH ) announced today that management ... Conference on Tuesday, August 16, 2011 at 2:25 P.M. ET ... an overview of the Company,s business strategy and recent corporate ... invitation only. Delcath will offer a live audio webcast of ...
... 10, 2011 Leading events organizers UBM Canon ... (LSE: UBM), today announced a virtual conference event which will examine ... chain, counterfeit drugs. Titled ,Pharmaceutical Track & Trace Authentication: The Fight ... from 6:00 to 14:00 New York time, 12:00 to 20:00 Paris ...
Cached Medicine Technology:Delcath to Present at the Wedbush 2011 Life Sciences Conference on August 16, 2011 2Delcath to Present at the Wedbush 2011 Life Sciences Conference on August 16, 2011 3UBM Canon Introduces a Compelling New Virtual Conference Focused on Track & Trace Solutions for the Pharma Sector 2UBM Canon Introduces a Compelling New Virtual Conference Focused on Track & Trace Solutions for the Pharma Sector 3
Sprint Quattro Secure™ is a Steroid-Eluting, True Bipolar, Active Fixation ICD Lead....
The Livewire steerable electrophysiology catheter is uniquely designed with an ergonomic handle and patented steering mechanism to provide smooth, precise catheter tip movement, even during lengthy e...
The Livewire cannulator offers improved access to the coronary sinus by combining the ergonomic Livewire steering mechanism with numerous specialized features....
Trilogy Pacemakers incorporates the clinically proven Omniscence™ accelerometer sensor with it's automatic alogorithms. The Trilogy family of pacemakers feature an array of products for bradyar...
Medicine Products: