Navigation Links
New DNA repair pathway
Date:11/9/2010

UC Davis researchers have found a new pathway for repairing DNA damaged by oxygen radicals. The results are published this week in the journal Proceedings of the National Academy of Sciences.

"This new inducible pathway gives cells greater capacity to repair oxidative damage," said Peter Beal, professor of chemistry at UC Davis and senior author of the paper.

As part of its inflammatory response, the body's immune system produces oxygen radicals, or reactive oxygen species, to kill bacteria, parasites or tumors. But chronic inflammation, for example in the gut, has been linked to cancer, said co-author Professor Sheila David, also of the Department of Chemistry.

Oxygen radicals are strongly linked to cancer and aging and are also formed during metabolism and upon exposure to environmental toxins and radiation. Understanding more about how this damage can be repaired could lead to a better understanding of the causes of some cancers.

Oxygen radicals can react with the four bases that make up the "letters" of DNA -- A, C, G and T -- so that the "spelling" of genes gets changed. The accumulation of spelling errors (called mutations) can lead to cancer.

David's laboratory studies an enzyme called NEIL1 that detects and repairs these aberrant or damaged bases before changes in the genome become permanent.

Beal's group works on RNA editing. The first step in turning a gene into a protein is to make a copy of the DNA in RNA. This messenger RNA is then translated into the chain of amino acids that makes up a protein. In some cases, this RNA is "edited" between the transcription from DNA and the translation into protein.

At a conference last year, Beal -- who happens to be David's husband -- spotted NEIL1 among a list of genes that had just been discovered to be subject to RNA editing, and passed the news on to David.

On investigation, they found that NEIL1's messenger RNA is edited by an enz
'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
2. $250,000 grant awarded for groundbreaking ligament and tendon repair research
3. $250,000 Grant Awarded for Groundbreaking Ligament and Tendon Repair Research
4. Vitamin B3 May Help Repair Brain After a Stroke
5. Clitoraid Announces New Round of Clitoral Repair Surgeries in U.S. for FGM Victims
6. EPA's New Lead-Based Paint (LBP) Renovation, Repair and Painting Rule (RRP) Causes Headaches for Contractors and Property Owners Alike
7. Repair of torn knee meniscus at the time of ACL reconstruction is safe and effective for children
8. Minimally invasive sports hernia repair may get athletes back in the game faster, study says
9. Newly identified proteins critical to FA pathway DNA repair function
10. Stirling Dental Laboratory, Experts in Emergency Denture Repair Service, Gives Back to Community
11. Cedars-Sinai study examines regional use of minimally invasive repair of aneurysms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Aug. 20, 2014 (HealthDay News) -- Pigs, hearts transplanted ... is twice as long as previously achieved, researchers report. ... ways to use animal organs to shorten transplant waiting ... genetically engineered piglets into baboons, abdomens. The genetic engineering ... response are what enabled the hearts to survive for ...
(Date:8/20/2014)... Thompson HealthDay Reporter WEDNESDAY, ... older women avoid a condition that causes a life-threatening irregular ... had a 10 percent lower risk of developing atrial fibrillation, ... the Aug. 20 issue of the Journal of the ... against the heart rhythm disorder even if they were obese, ...
(Date:8/20/2014)... New York, NY (PRWEB) August 20, 2014 ... and architecture firm Perkins Eastman is pleased ... and design services in China and ... internationally recognized Principal Richard Sprow AIA has ... continue his 40-year career in healthcare planning and design ...
(Date:8/20/2014)... A common approach to treating kidney failure by removing ... chances for people who suddenly developed the condition, in ... Pittsburgh School of Medicine. , Their findings, published online ... hemodialysis, an aggressive method that is standardly used for ... definitive benefit to the patient. , "Our findings question ...
(Date:8/20/2014)... New York (PRWEB) August 20, 2014 ... the use of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) ... notes that two U.S. Senators from New York are ... seek a recall of the devices. In a letter ... both Democrats, also implored the agency to seriously consider ...
Breaking Medicine News(10 mins):Health News:Pigs' Hearts Beat for a Year in Baboons' Abdomens 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 3Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3Health News:Pitt analysis questions use of acute hemodialysis treatment 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4
... and candidates faster, brings unprecedented functionality and ease of use to ... ... -- Dayak, the leading online recruiting marketplace used by ... more efficiently, today launched a new version of its user interface ...
... are trying to economize by choosing cheaper shipping methods , ... ... www.medisave.net ), a leading global medical equipment merchant with ... today announced that despite the global credit crunch, global sales have ...
... Indication this Year; Data Demonstrate High,Durable Response Rates ... a Rituximab-Containing Regimen, FRAZER, Pa., Nov. 3 ... U.S. Food and Drug Administration (FDA) has,approved TREANDA(R) ... with indolent B-cell non-Hodgkin,s lymphoma (NHL),that has progressed ...
... of Allergy and Infectious Diseases (NIAID) scientist Theodore E. ... with areas of brain tissue swelling in people infected ... form around dead, calcified cysts that result when larvae ... brain. The illness caused by T. solium ...
... provider team up to market ... final expense planning, ... Corporation International (NYSE: SCI ) have formed a,unique partnership through ... Final Expense insurance., This is an extraordinary combination of services ...
... 2008, JUPITER, Fla., Nov. 3 From November 15 -17, ... promote,National Smoke Out Day, November 20, and to promote her new ... -- MISS AMERICA 2008 KIRSTEN HAGLUND, WILL BE AVAILABLE ... NOVEMBER 15-17 TO PROMOTE SAVING LIVES, AND ...
Cached Medicine News:Health News:Dayak Makes Hiring Even Easier, Unveils New Version Of Web Interface For Employers 2Health News:Dayak Makes Hiring Even Easier, Unveils New Version Of Web Interface For Employers 3Health News:Despite Credit Crunch, Medisave Sees Strong Sales Increase in 2008 2Health News:Despite Credit Crunch, Medisave Sees Strong Sales Increase in 2008 3Health News:Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma 2Health News:Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma 3Health News:Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma 4Health News:Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma 5Health News:SLAICO and SCI Form Partnership 2
(Date:8/20/2014)... , Aug. 20, 2014  The National Association ... latest results achieved by the real-time, pseudoephedrine (PSE) ... National Precursor Log Exchange (NPLEx), automatically blocks unlawful ... down meth offenders and make arrests. Data released ... Kentucky blocked the sale of more ...
(Date:8/20/2014)... Md. , Aug. 20, 2014  The ... lauded the latest results achieved by the real-time, ... as the National Precursor Log Exchange (NPLEx), automatically ... officials track down methamphetamine offenders and make arrests. ... Michigan blocked the sale ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... available in its catalogue: The Impact ... Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... (H.R. 3590) is complex legislation that affects virtually ... its provisions are beginning to take effect now. ...
Breaking Medicine Technology:Kentucky's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6
... , NEW YORK, Nov. ... research report is available in its catalogue. , ... Perspective , http://www.reportlinker.com/p0164373/Pipettes--Pipettors---A-Global-Market-Perspective.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ... integral part of any research laboratory. Large-scale applications ...
... , NEW YORK, Nov. ... research report is available in its catalogue. , ... , http://www.reportlinker.com/p0164742/Global-Markets-for-Assisted-Reproductive-Devices-2009.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire , ... 15 Countries in Europe and Japan. This report ...
Cached Medicine Technology:Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 2Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 3Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 4Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 5Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 6Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 7Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 8Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 9Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 10Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 11Reportlinker Adds Pipettes & Pipettors - A Global Market Perspective 12Reportlinker Adds Global Markets for Assisted Reproductive Devices 2009 2
Replacement bulb for Vibratome light system....
The V-Block adapter is designed to allow round posts to be placed in the Vibratome vice....
This is a perfect tool for retrieving free floating sections from the Vibratome bath....
... Works includes everything from the care ... fuse, Spare Fluorescent Bulb, additional Vibratome ... Blocks, and a Specimen Tray. ... stage, 1/2" speciment mounts, replacement rotating ...
Medicine Products: