Navigation Links
New Compound Slows HIV Replication

It could mean development of new class of drugs, researchers say

WEDNESDAY, May 28 (HealthDay News) -- A new compound that inhibits HIV protease has been developed by researchers at the University of Michigan.

The protease, which is necessary for HIV replication, is a common target in the treatment of HIV patients. But this is the first new HIV protease inhibitor compound to be developed in 20 years and could lead to a new class of HIV/AIDS drugs, according to the researchers, who created the compound using computer models and then confirmed its effectiveness in laboratory tests.

This new compound debilitates the HIV-1 protease in a different way than current protease inhibitors, which bind to the center of the protease, freezing it closed, and preventing it from processing the proteins needed to assemble an active virus.

The new compound targets a different area of the protease and holds it open, which also inhibits its activity.

"In a way, this works like a door jam. If you looked only at the door when it's shut, you'd not know you could put a jam in it. We saw a spot where we could block the closing event, but because everyone else was working with the closed form, they couldn't see it," principal investigator Heather Carlson, a professor of medicinal chemistry in the College of Pharmacy, said in a prepared statement.

The new compound's molecules are smaller, which means they're absorbed much more easily.

"This new class of smaller molecules could have better drug properties (and) could get around current side effects," Carlson said. "HIV dosing regimes are really difficult. You have to take medicine several times a day. Maybe you wouldn't have to do that with these smaller molecules, because they would be absorbed differently."

Research into this new compound is still in the preliminary stages, she noted.

"It's very easy to make an inhibitor, [but] it's hard to make a drug. This compound is too weak to work in the human body. The key is to find more compounds that will work by the same mechanism," Carlson said.

More information

The National Institute of Allergy and Infectious Diseases has more about HIV treatment.

-- Robert Preidt

SOURCE: University of Michigan, news release, May 14, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
(Date:11/29/2015)... ... 2015 , ... Effective immediately, every single IguanaMed scrub style will be available ... is offering a “Buy One Scrub Set, Get the 2nd Scrub Set 50% Off” ... at a discounted price. , IguanaMed’s mission is to outfit every healer ...
(Date:11/28/2015)... ... November 28, 2015 , ... Safe storage for contraceptive devices may not ... from Lakewood, New Jersey and the other from Bradley Beach, New Jersey, there is ... the expense of having to replace NuvaRings more often than necessary. As such, it ...
(Date:11/28/2015)... ... 2015 , ... Pixel Film Studios is back again with ProPanel: Pulse ... are endless. Users have full control over angle of view, speed method, start point, ... sure to get heads to turn. , ProPanel: Pulse offers fully customizable pulsating shape ...
(Date:11/27/2015)... ... 2015 , ... According to an article published November 6th by ... University of British Columbia suggested that laws requiring bicyclists to wear helmets may not ... of the reason for the controversial conclusion is that, while helmets have certainly prevented ...
(Date:11/27/2015)... , ... November 27, 2015 , ... A team of ... ways to treat it. Surviving Mesothelioma has just posted the findings on the website. ... Hospital Zurich analyzed the cases of 136 mesothelioma patients who were treated with chemotherapy ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 --> ... to use SyMRI to find optimal contrast weighting of MRI ... metastases, and has signed a research agreement with SyntheticMR in ... hospital. Using SyMRI, it is possible to generate multiple contrast ... after the patient has left, thus making it possible to ...
(Date:11/26/2015)... -- Research and Markets ( ) has ... Horizons and Growth Strategies in the Japanese Therapeutic ... Forecasts, Competitive Intelligence, Emerging Opportunities" report to ... --> This new 247-page report provides ... monitoring market, including emerging tests, technologies, instrumentation, sales ...
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
Breaking Medicine Technology: