Navigation Links
New Compound Slows HIV Replication
Date:5/28/2008

It could mean development of new class of drugs, researchers say

WEDNESDAY, May 28 (HealthDay News) -- A new compound that inhibits HIV protease has been developed by researchers at the University of Michigan.

The protease, which is necessary for HIV replication, is a common target in the treatment of HIV patients. But this is the first new HIV protease inhibitor compound to be developed in 20 years and could lead to a new class of HIV/AIDS drugs, according to the researchers, who created the compound using computer models and then confirmed its effectiveness in laboratory tests.

This new compound debilitates the HIV-1 protease in a different way than current protease inhibitors, which bind to the center of the protease, freezing it closed, and preventing it from processing the proteins needed to assemble an active virus.

The new compound targets a different area of the protease and holds it open, which also inhibits its activity.

"In a way, this works like a door jam. If you looked only at the door when it's shut, you'd not know you could put a jam in it. We saw a spot where we could block the closing event, but because everyone else was working with the closed form, they couldn't see it," principal investigator Heather Carlson, a professor of medicinal chemistry in the College of Pharmacy, said in a prepared statement.

The new compound's molecules are smaller, which means they're absorbed much more easily.

"This new class of smaller molecules could have better drug properties (and) could get around current side effects," Carlson said. "HIV dosing regimes are really difficult. You have to take medicine several times a day. Maybe you wouldn't have to do that with these smaller molecules, because they would be absorbed differently."

Research into this new compound is still in the preliminary stages, she noted.

"It's very easy to make an inhibitor, [but] it's hard to make a drug. This compound is too weak to work in the human body. The key is to find more compounds that will work by the same mechanism," Carlson said.

More information

The National Institute of Allergy and Infectious Diseases has more about HIV treatment.



-- Robert Preidt



SOURCE: University of Michigan, news release, May 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... ... and Richard Pedranti Architect (RPA), a full-service architecture firm focusing on ... Solsken Line of Model Homes . Independently, Ecocor and RPA have extensive ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... consulting firm in Pennsylvania, is pleased to offer in-home and online newborn ... that sleep deprivation has on the body,” says company owner Courtney Zentz, a ...
(Date:9/22/2017)... ... , ... Happy Living’s mission - to improve the health and wellbeing of ... and delicious worlds of theatre and wines. , After watching Scott Barry perform ... his play into a book. The Greener The Grass ( https://www.happyliving.com/books/the-greener-the-grass ) was published ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Cursed ... of an obligatory tithe, and the freedom experienced when breaking free from this ... published author, Lysa M. Harrison. , Published by Christian Faith Publishing, Lysa M. ...
(Date:9/22/2017)... ... September 22, 2017 , ... First Choice Emergency ... the one year anniversary of its Houston-Fallbrook facility. , “We are honored ... Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has been a pleasure ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Texas , Sept. 7, 2017 ... science focused on fulfilling the promise of precision ... further validate the benefits of its molecular profiling ... study utilized comprehensive genomic profiling plus (CGP+) with ... individual patient,s tumor on a molecular level, leading ...
(Date:9/7/2017)... 7, 2017   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade cell and tissue hypothermic storage ... Mike Rice , President and CEO, will be presenting at ... Rodman & Renshaw 19 th Annual Global Investment Conference ... p.m. Pacific time). The conference is being held at the ...
(Date:9/6/2017)...   PDI , a leader in infection prevention ... educational session focused on the role of chlorhexidine gluconate ... the 2017 Annual Scientific Meeting of the Association for ... the Phoenix Convention Center in ... will also feature PDI,s Prevantics® Device Swab ...
Breaking Medicine Technology: