Navigation Links
New Compound Shrinks Skin Cancers
Date:9/2/2009

o had distant metastases saw a reduction in tumor size, as did 60 percent of those with locally advanced cancer. The rest had either stable or progressive disease after 10 months of follow-up.

But "stable" in this population may not mean much, Perlis pointed out, as it is generally a very slow-growing cancer.

The man with medulloblastoma also saw a significant shrinkage of his tumor, along with vastly improved quality of life, but only for two months. He later died.

A third study by some of the same authors, this one published online Sept. 2 in Science Express, discovered that treatment with GDC-0449 actually spurred another mutation in a gene called SMO, which caused the brain tumor to become resistant to the drug.

Because the Hedgehog pathway does not actually do much in adults, side effects were minimal, said de Sauvage.

GDC-0449 would likely be used very differently, depending on which type of cancer it is targeting.

In the case of basal cell carcinoma and medulloblastoma, the mutation in the Hedgehog pathway "really drives the formation of these tumors," de Sauvage said. "This molecule inhibits the pathway very specifically and, to date, we only know of these two types of tumor where the pathway is mutated." That means GDC-0449 is effective on its own.

But in colon and ovarian cancer, he continued, the pathway recruits surrounding cells to promote the cancer. In these types of tumors, GDC-0449 would have to be combined with other drugs.

More information

The American Academy of Dermatology has more on basal cell carcinoma.



SOURCES: Clifford Perlis, M.D., director, Mohs Micrographic Surgery and Dermatologic Surgery, Fox Chase Cancer Center, Philadelphia; Andrzej Dlugosz, professor, department of dermatology, University of Michigan M
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Compound Shrinks Skin Cancers
(Date:7/29/2015)... Miami, FL (PRWEB) , ... July 29, 2015 , ... ... diagnosis patients suffering from drug or alcohol addiction and mental health disorders. Acu-detox may ... means of treating patients recovering from drug and alcohol addiction. Although acupuncture is not ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... Campbell Agency has once again teamed up with Stillwaters Cancer Support Services and ... their families. Stillwaters provides individual and family counseling, support groups, workshops and educational ...
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... Orthopedic ... to now offer the Rotation Medical Rotator Cuff System, a new implant to treat ... implant is designed to foster natural regeneration of additional tendon tissue, which could allow ...
(Date:7/29/2015)... Minneapolis, Minnesota (PRWEB) , ... July 29, 2015 , ... ... The Sofia Fund, which invests in women-led, growth companies and is led by a ... Investors have responded positively, and voted with their dollars to be a part ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... We are privileged to announce that ... of USC as the ninth best ophthalmology hospital in the nation for 2015-2016. This marks ... American hospitals for ophthalmology. , “It is an honor to be included in the ...
Breaking Medicine News(10 mins):Health News:Miami Drug Rehab Introduces Acupuncture to Line of Holistic Healing for Addiction 2Health News:Miami Drug Rehab Introduces Acupuncture to Line of Holistic Healing for Addiction 3Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 2Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 3Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 2Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 3Health News:Sofia Fund Surpasses Investor Goals 2Health News:21 Years & Counting: The USC Eye Institute Ranks in the Top 10 Ophthalmology Hospitals in America 2Health News:21 Years & Counting: The USC Eye Institute Ranks in the Top 10 Ophthalmology Hospitals in America 3
... Covance Inc. (NYSE: CVD ) today announced that ... Lynch 2009 Health Care Conference on Thursday, May 14, 2009 ... webcast of the presentation at www.covance.com . ... please log on 10 minutes early.Covance, with headquarters in Princeton, ...
... Edible Egg(TM) Partners with Science Olympiad to Emphasize the ... 13 Where can you find America,s brightest young ... activities and many more are part of the 25th ... May 16. For the first time, the incredible edible ...
... awarded a 5-year contract to provide medical transcription service to the ... at Pueblo. , ... Hauppauge, NY (PRWEB) May 13, ... awarded a 5-year contract to provide medical transcription services for the ...
... Tour is targeting drug and alcohol abuse in Tonga, an island nation ... ... -- A Scientology Volunteer Ministers Goodwill Tour is targeting drug ... South Pacific., , ,In an interview with Radio Tonga News on the ...
... reports on an alarming and controversial policy change made by Blue Cross ... impact on the entire venous community--from patients to physicians to the businesses ... ... 13, 2009 -- As of mid April, 2009, BCBS has mandated that ...
... increased funding coexists with fears and stigmaNEW YORK, May ... infected with HIV fare in the U.S. health care ... a new focus group study released today by ... organization. The report, prepared for THE NATIONAL AIDS ...
Cached Medicine News:Health News:America's Top Young Scientists to Receive Scholarships for Winning Eggs-Periments 2Health News:America's Top Young Scientists to Receive Scholarships for Winning Eggs-Periments 3Health News:America's Top Young Scientists to Receive Scholarships for Winning Eggs-Periments 4Health News:ZyDoc Medical Transcription Wins Colorado Mental Health Institute Contract Award 2Health News:ZyDoc Medical Transcription Wins Colorado Mental Health Institute Contract Award 3Health News:Scientology Volunteer Ministers Target Drug and Alcohol Abuse in the South Pacific 2Health News:Blue Cross/Blue Shield Of Massachusetts Introduces Controversial Criteria For Vein Treatment Reimbursement 2Health News:Blue Cross/Blue Shield Of Massachusetts Introduces Controversial Criteria For Vein Treatment Reimbursement 3Health News:Many Americans Worry About How People With HIV/AIDS Fare in the U.S. Health System 2Health News:Many Americans Worry About How People With HIV/AIDS Fare in the U.S. Health System 3
(Date:7/29/2015)... July 29, 2015  Fifty groups representing 500,000 patients, ... 29, to launch the AllTrials campaign in the US. ... present, and future, to be registered and the results ... Ben Goldacre explains: "Patients want the treatments ... evidence on what works. Unfortunately, we now know that ...
(Date:7/29/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/hmjqff/global_wound_care ) has ... Care Markets (Twelve Country Analysis: Germany, France, Italy, ... Brazil, Australia, South Korea)" report to their ... competitive market summary. The wound care market is ... product maturity. Several of the products within the ...
(Date:7/29/2015)... REDMOND, Washington , 29. Juli 2015 ... deutschen Diabeteszentrums wurde festgestellt, dass die tägliche ... von Nutraceutix die menschliche Darmflora anreichert und ... Insulinsekretion erhöhen. Die Studie umfasste die tägliche ... (ATCC-Stamm SD-5865) in Tablettenform unter Verwendung der ...
Breaking Medicine Technology:Fixing Your Medicine: AllTrials Campaign Launches in US 2Fixing Your Medicine: AllTrials Campaign Launches in US 3Global Wound Care Markets 2015 2Klinischer Nachweis erbracht, dass L. reuteri Probiotikum von Nutraceutix den Darm-Insulinmetabolismus moduliert 2
... The K Series CryoStorage System from ... liquid nitrogen stroage from -100C to ... solid-state automatic controls, easy accessibility to ... crogenic termperatures. On the larger systems, ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTP/1Q-PAL chairs are recommended for ... clean room, static control, health care ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With polished ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTP/1Q-PAL chairs are recommended for the ... room, static control, health care and ...
Medicine Products: