Navigation Links
New Compound Shrinks Skin Cancers
Date:9/2/2009

o had distant metastases saw a reduction in tumor size, as did 60 percent of those with locally advanced cancer. The rest had either stable or progressive disease after 10 months of follow-up.

But "stable" in this population may not mean much, Perlis pointed out, as it is generally a very slow-growing cancer.

The man with medulloblastoma also saw a significant shrinkage of his tumor, along with vastly improved quality of life, but only for two months. He later died.

A third study by some of the same authors, this one published online Sept. 2 in Science Express, discovered that treatment with GDC-0449 actually spurred another mutation in a gene called SMO, which caused the brain tumor to become resistant to the drug.

Because the Hedgehog pathway does not actually do much in adults, side effects were minimal, said de Sauvage.

GDC-0449 would likely be used very differently, depending on which type of cancer it is targeting.

In the case of basal cell carcinoma and medulloblastoma, the mutation in the Hedgehog pathway "really drives the formation of these tumors," de Sauvage said. "This molecule inhibits the pathway very specifically and, to date, we only know of these two types of tumor where the pathway is mutated." That means GDC-0449 is effective on its own.

But in colon and ovarian cancer, he continued, the pathway recruits surrounding cells to promote the cancer. In these types of tumors, GDC-0449 would have to be combined with other drugs.

More information

The American Academy of Dermatology has more on basal cell carcinoma.



SOURCES: Clifford Perlis, M.D., director, Mohs Micrographic Surgery and Dermatologic Surgery, Fox Chase Cancer Center, Philadelphia; Andrzej Dlugosz, professor, department of dermatology, University of Michigan M
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Compound Shrinks Skin Cancers
(Date:9/4/2015)... ... September 04, 2015 , ... Mile High Connects today releases “First and ... of funding for sidewalks, bike paths, and other vital supports severely limit access to ... spends billions of dollars to expand public transit, there’s very little support for safe ...
(Date:9/4/2015)... ... September 04, 2015 , ... Georgia ... is launching a charity effort to provide for the family of Grace, a ... enlarged heart, restrictive cardiomyopathy often leads to diastolic dysfunction – the inability to ...
(Date:9/4/2015)... Dallas, Texas (PRWEB) , ... September 04, 2015 ... ... the recipient of three separate “Partner of the Year” awards at this year’s ... included being named Microsoft’s 2015 “Partner of the Year” Award Winner for Data ...
(Date:9/4/2015)... Dallas, TX (PRWEB) , ... September 04, 2015 , ... ... in Iraq in 2007, will compete in the Ironman World Championships in Kona on ... veterans who have incurred Traumatic Brain Injury (TBI) through combat and the cutting-edge treatments ...
(Date:9/4/2015)... , ... September 04, 2015 , ... ... the microbiome taking place in Hollywood, Florida October 9-10, 2015 at the Diplomat ... at the 2015 symposium are doctors and researchers at the top of their ...
Breaking Medicine News(10 mins):Health News:Missed Connections in Metro Denver Transit 2Health News:Georgia Insurance Advisors Inaugurates Charity Drive to Assist the Family of Young Local Girl Diagnosed with an Enlarged Heart 2Health News:Georgia Insurance Advisors Inaugurates Charity Drive to Assist the Family of Young Local Girl Diagnosed with an Enlarged Heart 3Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 2Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 3Health News:Scalability Experts is Awarded Three Separate 2015 “Partner of the Year” Awards at Microsoft’s Worldwide Partner Conference 4Health News:Navy SEAL Shot 27 Times Competes in Ironman World Championship in Kona to Raise Money for Veteran's Suffering from TBI and PTSD 2Health News:Integrative Healthcare Symposium Focus On: The Microbiome Conference Program Announced 2
... approval from the USFDA to market Pravastatin Sodium Tablets in ... given for strengths of 10 mg, 20 mg, 40 mg ... ,The company would market the drug through its US ... ,The drug, which had branded sales of approximately 1.8 ...
... been appointed honorary consultant and adviser to the Armed ... and reconstructive micro surgery. // ,Sabapathy, Director ... Medical Centre and Hospitals, would give free consultation and ... the country, an hospital release said today., ,When ...
... more iron compared to breast milk, suggests a research ... can be caused// due to high intake of iron ... which was fed with human equivalent iron supplementation from ... long been shown to have elevated levels of iron ...
... passive smoking worsens allergies.The study, entitled “Challenge with environmental ... can be found in the Articles in Press area ... Web site located at www.jacionline.org. The JACI is the ... & Immunology (AAAAI). ,David Diaz-Sanchez, PhD, University of ...
... well leave several junior doctors jobless. The British Medical Association estimates// ... training posts next year. ,Most of them have already ... million pounds of the taxpayer’s money to train and now would ... many more could be left unemployed. ,The new situation ...
... appointed a new president has expressed the need for ... ,Dr Mary Mc Caffrey, a consultant obstetrician gynecologist ... be gained by a consultant being in an operating ... present. The reforms we need will come when health ...
Cached Medicine News:Health News:Infant Formula With High Iron Content Packs Brain Disorder 2Health News:Infant Formula With High Iron Content Packs Brain Disorder 3Health News:Passive Smoking Worsens Allergies 2Health News:Several Junior Doctors Could Be Rendered Jobless 2
(Date:9/3/2015)... , Sept. 3,  2015 About ... bio-artificial devices, which are implanted or integrated ... organs. These include artificial heart, kidney, pancreas, ... polymers (polyurethane, polysulfone, and porous polypropylene), biologics, ... artificial organs. These organs are incorporated with ...
(Date:9/3/2015)... 3, 2015 About dry eye syndrome Dry ... to deficient tear production or quick tear evaporation or ... types: aqueous tear deficient dry eye and evaporative dry ... do not produce enough tears, whereas meibomian gland dysfunction ... to slow tear evaporation and maintain tear stability. The ...
(Date:9/3/2015)... Sept. 3, 2015  Ascendis Pharma A/S ... biotechnology company that applies its innovative TransCon ... today announced plans to present at several ... Healthcare Conference in BostonDate: , Thursday, September ... of America Merrill Lynch Global Healthcare Conference ...
Breaking Medicine Technology:Global Artificial Organ Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2Ascendis Pharma A/S to Present at Three Upcoming Investor Conferences 2
... WIRE)--May 21, 2007 - Cougar Biotechnology,Inc. (OTCBB:CGRB) today ... on the Company's prostate cancer drug candidate CB7630,(abiraterone ... Annual Meeting, which is currently taking place,in Anaheim, ... A.,Yap from the Cancer Research UK Centre for ...
... 40/12.5 and 40/25 mg/day and Amlodipine +,Benazepril ... Society of,Hypertension Twenty-Second Annual Scientific Meeting, PARSIPPANY, ... data,presented today at the American Society of ... Chicago,demonstrated that the fixed-dose combination Benicar HCT,(olmesartan ...
Cached Medicine Technology:Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 2Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 3Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 4Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 2Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 3Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 4Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 5Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 6Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 7Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 8
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: