Navigation Links
New Combo Therapy May Prevent TB, Save Lives in People With HIV
Date:7/6/2011

WEDNESDAY, July 6 (HealthDay News) -- Simpler and shorter treatment with antibiotic drugs could help prevent full-blown tuberculosis in millions of people worldwide infected with the bacterium that causes TB, especially those also infected with HIV, researchers report.

TB, or tuberculosis, is the leading cause of death among people co-infected with HIV, the virus that causes AIDS. About half a million people with both infections die worldwide every year.

The new study by an international team of scientists included 1,148 South African men and women infected with the TB bacterium and HIV, who were followed for up to six years to see whose TB infections stayed dormant.

It found that the most streamlined combination treatment -- a high dose of 900 milligrams each of the newer antibiotic rifapentine (Priftin) and the traditional anti-TB antibiotic isoniazid once weekly for three months -- worked as well or better than the current gold standard of care of 300 mg of isoniazid taken daily for six months or longer.

Of the study volunteers, about 3.1 percent on the shorter drug regimen developed active TB or died each year, compared to 3.6 among those on the standard daily regimen. Without treatment, researchers estimated that the mortality rate would have doubled.

Compliance with the drug regimen was also 95 percent for the shorter regimen, compared to 60 percent that other studies showed for the standard regimen.

The study appears online July 7 in the New England Journal of Medicine.

"This new, simpler treatment regimen with rifapentine and isoniazid is highly effective and could transform therapy for latent tuberculosis in both those co-infected with HIV and those not," senior author Dr. Richard Chaisson, a professor of infectious diseases at the Johns Hopkins University School of Medicine and founding director of its Center for Tuberculosis Research, said in a Hopkins news release.

"New treatment options are urgently needed to help control TB globally, and simpler regimens will substantially increase the number of people receiving therapy," Chaisson added.

He noted that fewer than 1 percent of those infected and most likely to develop full-blown TB receive drug treatment because of factors such as inconvenience, drug side effects and difficulty finding nearby health clinics.

More information

The U.S. National Institute of Allergy and Infectious has more about TB.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, July 7, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Vitamin D, Calcium Combo May Halve Melanoma Risk in Some Women
2. Energy Drink-Vodka Combo Nearly Kills Teen
3. Daily Four-Drug Combo Pill Halves Heart Disease Risk: Study
4. Combo of Paxil, Pravachol May Raise Blood Sugar
5. Chemo Combo May Help Stave Off Pancreatic Cancer Death
6. Alcohol-Energy Drink Combo Riskier Than Booze Alone, Study Says
7. Low-Intensity Exercise, Drug Combo Can Help Parkinsons Patients, Studies Show
8. Diet-Exercise Combo Seems to Work Best for Obese Seniors
9. Risks May Outweigh Benefits for Blood Pressure Drug Combo
10. In Women, Diabetes Plus Depression a Deadly Combo
11. New combo lung cancer therapy improves survival over single-line treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Combo Therapy May Prevent TB, Save Lives in People With HIV
(Date:2/5/2016)... San Rafael, CA (PRWEB) , ... February 05, 2016 , ... ... partnership with ChildLight Yoga Studio in Dover, NH to direct high-performance kids yoga training. ... on New Hampshire’s seacoast, just one hour from Boston. , ChildLight Yoga Studio founder ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... in gym use and find themselves having to wait longer to access the treadmills. ... on their New Year’s resolutions to lose weight and get in shape by joining ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, a leading ... Software & Services for HIT Implementation Support & Staffing report with an outstanding ... performance by healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 ...
(Date:2/5/2016)... ... 2016 , ... Stuart Bentkover, MD, FACS is thrilled to announce ... most effective tattoo removal today, Dr. Bentkover is the only doctor in Central Massachusetts ... PicoSure has been approved by the Food and Drug Administration (FDA) as a safe ...
(Date:2/5/2016)... ... 05, 2016 , ... In sleep, when the defenses of the day are ... of patients with eating disorders is significant self-criticism, and consequently these patients experience this ... regarded as maladaptive means for coping with this unease, but also leads to a ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Ala. , Feb. 5, 2016  Patients in ... high intensity focused ultrasound (HIFU) therapy no longer have to ... to announce its partnership with Urology Centers of Alabama ... the newly FDA-cleared procedure for qualifying patients. ... their expertise in the treatment of prostate cancer using many ...
(Date:2/5/2016)... --> --> ... the global active pharmaceuticals ingredients (APIs) market stood at ... US$185.9 bn by 2020. It is expected to expand ... The title of the report is "Active Pharmaceutical Ingredients ... by Therapeutic Area) - Global Industry Analysis, Size, Share, ...
(Date:2/5/2016)... HARROGATE, England , February 5, 2016 ... --> Today, VoicePower Ltd - The Speech Recognition People, ... has been deployed to improve patient care, reduce turnaround times and ... ,- Wirral CCG ,- VoicePower client since 2013 Challenge: ... Challenge: --> - Six doctors ,- Wirral ...
Breaking Medicine Technology: