Navigation Links
New Clues to the Evolution of the Human Brain
Date:5/3/2012

THURSDAY, May 3 (HealthDay News) -- New research suggests that a partial duplication of a gene played a significant role in a major advance in human brain evolution that occurred a few million years ago.

The SRGAP2 gene has been duplicated at least twice during human evolution, first about 3.5 million years ago and again about 2.5 million years ago. The second duplication produced only a partial copy of the gene, the study authors said.

This partial copy acts at exactly the same time and place as the original gene, allowing the partial copy to interact with and block the original gene's function, according to the findings published online May 3 in the journal Cell.

The partial copy of the SRGAP2 gene seems to have appeared at the same time that the fossil records show a transition from our extinct Australopithecus ancestors to the genus Homo, which led to and includes modern humans.

This point in human evolution is also when our ancestors' brains began to expand and major advances in intelligence likely occurred, according to Franck Polleux, an expert in brain development at Scripps Research Institute in La Jolla, Calif., and Evan Eichler, a genome scientist at the University of Washington in Seattle.

The researchers said that SRGAP2 and other human-specific gene duplicates may explain why humans are much more intelligent than other primates, despite few apparent differences in their genome sequences.

"We may have been looking at the wrong types of mutations to explain human and great ape differences," Eichler said in a journal news release. "These episodic and large duplication events could have allowed for radical -- potentially earth-shattering -- changes in brain development and brain function."

The findings also may provide clues to neurodevelopmental disorders, including autism, epilepsy and schizophrenia, the researchers said.

More information

The U.S. Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: Cell, news release, May 3, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Geisel researchers sift through junk to find colorectal cancer clues
2. Clues to Slacker Behavior Found in Brain, Study Says
3. Research yields new clues to how brain cancer cells migrate and invade
4. Ice Cream Headaches Might Offer Clues to Migraines
5. Study of half siblings provides genetic clues to autism
6. Researchers uncover new clues to the development of blood and other cancers
7. Newly identified stem cells may hold clues to colon cancer
8. Novel mouse model for autism yields clues to a 50-year-old mystery
9. New Clues to Link Between Fatty Diet, Colon Cancer
10. Protein structures give disease clues
11. New Genetic Clues to Breast Cancer?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Clues to the Evolution of the Human Brain
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
Breaking Medicine Technology: